Metal-metal interactions among dietary toxic and essential trace metals in the rat

Elsenhans, Bernd; Schmolke, G.; Kolb, K.; Stokes, Joanna D.; Förth, W.

doi:10.1016/0147-6513(87)90071-6

Cited by 37 publications

(21 citation statements)

References 13 publications

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“…These results are in line with previous studies by Elsenhans et al (1987) where a decrease of rat hepatic Cu concentration was observed after a 2-week administration of Cd.…”

Section: Discussionsupporting

confidence: 83%

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Pappas

Zoidis

Georgiou

et al. 2011

Food Additives & Contaminants: Part A

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“…These results are in line with previous studies by Elsenhans et al (1987) where a decrease of rat hepatic Cu concentration was observed after a 2-week administration of Cd.…”

Section: Discussionsupporting

confidence: 83%

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Pappas

Zoidis

Georgiou

et al. 2011

Food Additives & Contaminants: Part A

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“…Additionally, the activity of a metal in any given tissue is dependent on its speciation and metabolism (6). To further complicate the picture, metals have been shown to interact at multiple levels and, most likely, modify one another's cytotoxicity and/or carcinogenic potential (8)(9)(10)(11). As a result, we are still a long way from a fundamental understanding of the actions of metals or metal mixtures at the cellular level, particularly as they relate to toxic end points.…”

mentioning

confidence: 99%

Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology.

Bae

Hanneman

Yang

et al. 2002

Environ Health Perspect

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“…In this chapter, the inhibitory effect of Pb on Cd uptake in HepG2 cells seemed to be in agreement with some animal data mentioned in the ATSDR document. Hepatic levels of As and Pb were not affected by the existence of each other as reported in in vivo studies (Fairhall and Miller, 1941;Mahaffey et al, 1981;Elsenhans et al, 1987), which was also observed in our study.…”

Section: Interaction Effects Of As CD and Pb On Respective Uptake Insupporting

confidence: 79%

“…Throughout the literature, no study has reported the uptake interaction between binary mixtures of As, Cd and Pb in hepatocytes. Previous interaction data regarding the hepatic accumulation showed that As either decreased or had no effect on hepatic level of Cd whilst Cd was consistently reported to have no influence on As hepatic accumulation (Mahaffey et al, 1981;Elsenhans et al, 1987;Yanez et al, 1991). Even though our study utilised in vitro cell system, it was paralleled with in vivo results.…”

Section: Interaction Effects Of As CD and Pb On Respective Uptake Inmentioning

confidence: 99%

“…It is assumed that contaminants in the liver can reflect their overall systemic levels (Grøn, 2003) therefore liver is the key organ that can be considered when investigating the accumulation of As, Cd and Pb in human body. Previous in vivo experiments using rat suggest additive or antagonistic effects between binary mixtures of As, Cd and Pb (Fairhall and Miller, 1941;Mahaffey et al, 1981;Elsenhans et al, 1987;Yanez et al, 1991). However, due to time and cost constraint, ethical concerns, species difference, increasing numbers of chemicals and mixtures of chemicals, in vitro liver models have been established to mimic in vivo response, including liver slices, immortalised cell lines, primary hepatocytes, three-dimension cell culture system, bioartificial livers, and co-culture systems (Soldatow et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Assessing exposure risk of arsenic, cadmium and lead (or mixed with PAHs) in soils using in-vitro methods

Xia¹

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There are over 150,000 contaminated sites in Australia. In most cases, soils are polluted with mixtures of contaminants, including metal/metalloids. However, current human health assessment, particularly in relation to health investigation level guidelines is based on single contaminant. If no site-specific data are available, additive effect is assumed which may overestimate or underestimate the risk. Therefore, a more detailed study on the mixture of metal/metalloids is needed. The emphasis of this study is laid on the exposure risk of arsenic (As), cadmium (Cd), and lead (Pb) when they are ingested as mixtures. Two in-vitro models are adopted in this study. Model 1 is the Unified BARGE (Bioaccessibility Research Group of Europe) method (which is known as UBM) with the aim to measure the soluble fraction of soil contaminants in the human gastrointestinal tract (bioaccessibility) as well as the interaction effects of As, Cd and Pb on respective bioaccessibility. Model 2 is using human liver carcinoma cell line (HepG2) to study the subsequent uptake of contaminants into cells in target organ and possible interaction of As, Cd and Pb on their respective uptake after they are solubilised in the human digestive system. Considering at some contaminated sites polycyclic aromatic hydrocarbons (PAHs) may co-exist with As, Cd and Pb, effects of four selected PAHs (NAP for naphthalene, PHE for phenanthrene, PYR for pyrene, and B[a]P for benzo[a]pyrene) on the bioaccessibility and subsequent uptake of As, Cd and Pb into HepG2 cells are also preliminarily investigated. The focus of this PhD study is on mixtures of As, Cd and Pb.Seven chemically-variant top soils (0-20 cm) were collected in Australia. Soils were characterised for pH, total carbon, total nitrogen, total sulphur, total organic carbon, total inorganic carbon, cation exchange capacity, oxalate-extractable iron, aluminium and manganese, particle size distribution, electrical conductivity etc. A range of concentrations of As, Cd and Pb was spiked into these seven types of soils and aged for up to 12 months. UBM results show the bioaccessibility of As in the gastric phase was not significantly different from those in the intestinal phase whilst a pronounced difference was observed between Cd gastric bioaccessibility and intestinal bioaccessibility as well as between Pb gastric bioaccessibility and intestinal bioaccessibility. Organic carbon, iron oxide and aluminium oxide were key parameters influencing the bioaccessibility of As (gastric and intestinal phases), Cd (intestinal phase) and Pb (intestinal phase).For mixture studies, two exposure scenarios were investigated. Under the first scenario, As, Cd and Pb were spiked to individual soils to mimic independent ageing of mixed 3 contaminants, such as contaminants age at different spots or there has been a long time gap between different contaminants entering the same spot. The interaction between binary mixtures of As, Cd and Pb in simulated human digestive system was studied by mixing soils spiked with A...

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Metal-metal interactions among dietary toxic and essential trace metals in the rat

Cited by 37 publications

References 13 publications

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Influence of organic selenium supplementation on the accumulation of toxic and essential trace elements involved in the antioxidant system of chicken

Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology.

Assessing exposure risk of arsenic, cadmium and lead (or mixed with PAHs) in soils using in-vitro methods

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