Metal–metal interactions of dietary cadmium, copper and zinc in rainbow trout, Oncorhynchus mykiss

Kamunde, Collins; MacPhail, Ruth

doi:10.1016/j.ecoenv.2010.10.016

Cited by 40 publications

(19 citation statements)

References 40 publications

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“…The effect of Cu on mitochondrial respiration was assessed using a wide range (0-2500 M) of Cu concentrations (as CuSO 4 ·5H 2 O, Sigma-Aldrich Oakville, ON). This concentration regime falls within the range of Cu concentration (highest 7200 M) measured in livers and cytosolic fractions of fish and mice (with Atp7b gene knockout) following environmental and experimental Cu exposure (Bunton et al, 1987;Garceau et al, 2010;Ralle et al, 2010;Kamunde and MacPhail, 2011). The Cu concentrations were administered after ADP addition and Cu-impacted respiration rates were measured 3.5-4 and 8-8.5 min thereafter for state 3 and 4, respectively.…”

Section: Measurements Of Mitochondrial Respirationmentioning

confidence: 99%

Interactions of copper and thermal stress on mitochondrial bioenergetics in rainbow trout, Oncorhynchus mykiss

et al. 2014

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Section: Measurements Of Mitochondrial Respirationmentioning

confidence: 99%

Interactions of copper and thermal stress on mitochondrial bioenergetics in rainbow trout, Oncorhynchus mykiss

et al. 2014

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“…SM at 22 hpf, body length and heartbeat at 96 hpf, 23 mortality at 24 hpf, 3 and hatching rate at 72 hpf are very important representative signs (evaluating points) in our toxicity test, which are directly counted by the naked eye through a microscope to get physiologically real cardiac activity.…”

Section: Assessment Of Toxicity and Teratogenicitymentioning

confidence: 99%

“…3 Despite the fact that lead and copper are found together in many polluted environments, few detailed investigations have examined the combined effects of these two metals. Unlike other aquatic organisms, zebrafish embryos develop externally, and their bodies are transparent enough to characterization under a common optical microscope.…”

Section: Introductionmentioning

confidence: 99%

Comparative toxicity of lead (Pb2+), copper (Cu2+), and mixtures of lead and copper to zebrafish embryos on a microfluidic chip

Yang

Chen

et al. 2015

Biomicrofluidics

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Investigations were conducted to determine acute effects of Pb 2þ and Cu 2þ presented individually and collectively on zebrafish embryos. Aquatic safety testing requires a cheap, fast, and highly efficient platform for real-time evaluation of single and mixture of metal toxicity. In this study, we have developed a microfluidic system for phenotype-based evaluation of toxic effects of Pb 2þ and Cu 2þ using zebrafish (Danio rerio) embryos. The microfluidic chip is composed of a disc-shaped concentration gradient generator and 24 culture chambers, which can generate one blank solution, seven mixture concentrations, and eight single concentrations for each metal solution, thus enabling the assessment of zebrafish embryos.To test the accuracy of this new chip platform, we have examined the toxicity and teratogenicity of Pb 2þ and Cu 2þ on embryos. The individual and combined impact of Pb 2þ and Cu 2þ on zebrafish embryonic development was quantitatively assessed by recording a series of physiological indicators, such as spontaneous motion at 22 hours post fertilization (hpf), mortality at 24 hpf, heartbeat and body length at 96 hpf, etc. It was found that Pb 2þ or Cu 2þ could induce deformity and cardiovascular toxicity in zebrafish embryos and the mixture could induce more severe toxicity. This chip is a multiplexed testing apparatus that allows for the examination of toxicity and teratogenicity for substances and it also can be used as a potentially costeffective and rapid aquatic safety assessment tool. V C 2015 AIP Publishing LLC.

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“…Bull trout has been reported as the most tolerant species against toxicity of both Cd and Zn than rainbow trout. This tolerance ability appeared species specific and characterized by the less ability to lose Ca 2+ (Kamunde and MacPhail, 2011). All length groups of three fish species showed significant variations for their sensitivity to tolerate Cd toxicity.…”

Section: Discussionmentioning

confidence: 94%

Acute Toxicity of Cadmium and its Bio-accumulation in the Carnivorous Fish Species Channa marulius, Mystus seenghala and Wallago attu

Javed¹,

Abbas²,

Latif³

2016

IJAB

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To cite this paper: Javed, M., S. Abbas and F. Latif, 2016. Acute toxicity of cadmium and its bio-accumulation in the carnivorous fish species AbstractAcute toxicity of Cadmium (Cd) using 96 h LC50 and lethal concentrations was determined for the three fish species viz. Channa marulius, Mystus seenghala and Wallago attu. These toxicity tests were performed with three length groups (50, 100, 150 mm) of each fish species at constant water temperature (28ºC), pH (8) ). Fish mortality data were analyzed using Probit analysis method at 95% confidence interval to calculate 96 h LC50 and lethal concentrations of Cd. At the end of acute experiments, the organs (gills, kidney, liver, muscles) of dead fish were analyzed for Cd accumulation. Among the three carnivorous fish species, M. seenghala showed significantly higher sensitivity towards Cd toxicity followed by W. attu and C. marulius. However, 50 mm length group of all the three fish species exhibited significantly higher sensitivity towards Cd, followed by 100 and 150 mm length groups with significant differences. The organs of all fish species showed significant variations in their ability to amass Cd. However, C. marulius exhibited significantly (p<0.05) higher ability to amass Cd in its tissues followed by that of W. attu and M. seenghala. Among the fish organs, liver and kidney showed significantly higher ability to amass Cd during acute exposure of metal. This study will help in sustainable conservation of carnivorous fish species in the natural aquatic bodies of Pakistan.

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Metal–metal interactions of dietary cadmium, copper and zinc in rainbow trout, Oncorhynchus mykiss

Cited by 40 publications

References 40 publications

Interactions of copper and thermal stress on mitochondrial bioenergetics in rainbow trout, Oncorhynchus mykiss

Interactions of copper and thermal stress on mitochondrial bioenergetics in rainbow trout, Oncorhynchus mykiss

Comparative toxicity of lead (Pb2+), copper (Cu2+), and mixtures of lead and copper to zebrafish embryos on a microfluidic chip

Acute Toxicity of Cadmium and its Bio-accumulation in the Carnivorous Fish Species Channa marulius, Mystus seenghala and Wallago attu

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