Metal/Metal Oxide Modified Graphene Nanostructures for Electrical Biosensing Applications: A Review

Chakraborty, Bidesh; RoyChaudhuri, C.

doi:10.1109/jsen.2021.3082554

Cited by 11 publications

(3 citation statements)

References 159 publications

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“…Reduced graphene oxide (rGO) is a promising candidate for the preparation of high-performance modified electrodes because of its unique 2D structures, interesting electrocatalytic activity, and excellent conductivity ( Coros et al, 2020 ). Moreover, these characteristics can be tailored by making rGO as the building blocks with metal oxide and metal nanoparticles ( Chakraborty and Roychaudhuri, 2021 ). Metal oxide nanoparticles, such as TiO 2 , have garnered extensive attention in the design of a potential sensing interface due to their non-toxicity, high surface area, exceptional chemical stability, and notable electrochemical properties ( George et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode

Kong

et al. 2022

Front. Chem.

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An electrochemical sensor for sensitive sensing of acyclovir (ACV) was designed by using the reduced graphene oxide–TiO2–Au nanocomposite-modified glassy carbon electrode (rGO–TiO2–Au/GCE). Transmission electron microscopy, X-ray diffractometer, and X-ray photoelectron spectroscopy were used to confirm morphology, structure, and composition properties of the rGO–TiO2–Au nanocomposites. Cyclic voltammetry and linear sweep voltammetry were used to demonstrate the analytical performance of the rGO–TiO2–Au/GCE for ACV. As a result, rGO–TiO2–Au/GCE exerted the best response for the oxidation of ACV under the pH of 6.0 PB solution, accumulation time of 80 s at open-circuit, and modifier amount of 7 µl. The oxidation peak currents of ACV increased linearly with its concentration in the range of 1–100 µM, and the detection limit was calculated to be 0.3 µM (S/N = 3). The determination of ACV concentrations in tablet samples also demonstrated satisfactory results.

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Section: Introductionmentioning

confidence: 99%

Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode

Kong

et al. 2022

Front. Chem.

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“…Notably, graphene has emerged as a preferred material for electrochemical sensing due to its superior attributes, including enhanced electron transfer kinetics [3], substantial surface area of 2630 m 2 /g [4], excellent electrical conductivity [5], and an extensive potential window [6]. Despite graphene's excellent electrochemical properties, its uniform charge distribution and restacking property hinder the active sites and reduce the interaction between the analytes and graphene material [7]- [9]. Extensive research endeavors have focused on tailoring graphene's physical and chemical attributes through structural and chemical modifications to optimize electrocatalytic properties [10], [11].…”

Section: Introductionmentioning

confidence: 99%

Development of an Electrochemical Dopamine Sensor Using Nitrogen-Rich Sulfur Dual-Doped Reduced Graphene Oxide

Lavanya,

Aakash,

Sankar

et al. 2024

IEEE Access

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In the present work, we report on developing an electrochemical dopamine sensor using a novel material of nitrogen-rich sulfur dual-doped reduced graphene oxide (N-rich SRGO). Nitrogen and sulfur heteroatoms were incorporated into graphene sheets through a one-step, cost-effective hydrothermal approach to synthesize N-rich SRGO. Experimental investigations were carried out to compare the electrochemical properties of N-rich SRGO with nitrogen sulfur-doped reduced graphene oxide (NSRGO), nitrogen-doped reduced graphene oxide sheets (NRGO), and reduced graphene oxide (RGO) by modifying the glassy carbon electrode. Electrochemical studies demonstrated that N-rich SRGO exhibited a notably higher oxidation current (345 µA) compared to NSRGO (219 µA), NRGO (173 µA), and RGO (160 µA). We developed a dopamine sensor by utilizing the superior chemical reactivity and enhanced charge carrier density of the proposed N-rich SRGO-modified electrode. Experimental results reveal a high sensitivity of 142 µA/mM, with a limit of detection of 9.3 µM and a wide dynamic range of 0-350 µM. This N-rich SRGObased sensor displayed excellent repeatability and selectivity, even in the presence of other electroactive interferents, showcasing its potential for practical applications.

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“…32 At present, the application of carbon-based nanocomposites have been widely explored to fabricate electrochemical biosensor for sensing glucose, 7,[33][34][35] and were found to assist in direct electron transfer of glucose oxidase enzyme on the electrode surface for highly-sensitive glucose biosensor. [36][37][38] Interestingly, graphene has been hybridized with metal oxide nanoparticles such as TiO 2 nanoparticles to form a novel binary composite structure 39 that combines the high electrical conductivity of graphene and the mechanically strong composition of the TiO 2 . 40,41 The TiO 2 nanoparticles are preferred due to their large specific surface area, high reactivity and excellent biocompatibility for good sensitivity, response time and selectivity of biosensor.…”

mentioning

confidence: 99%

Development of Rapid Dispense-Printed Flexible Interdigitated Electrode Modified with rGO-TiO₂ Nanohybrid for Glucose Detection

Rezali

Aidit

Nouxman

et al. 2023

J. Electrochem. Soc.

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A rapid and facile method in developing a printed electrochemical glucose sensor constructed using flexible interdigitated electrode (IDE) employed with reduced graphene oxide (rGO)-Titanium dioxide (TiO2) is demonstrated. A 2x3 silver (Ag)-based IDE array based on a simulated IDE model, was fabricated via a single-step dispense-printing within less than five minutes, while a rGO-TiO2 nanohybrid and glucose oxidase (GOx) enzyme was coated on the IDE surface simply via drop-casting method. Exceptional reproducibility and repeatability of the printed IDE functionalized with rGO-TiO2/GOx in terms of electrical and mechanical performance were observed. The stability of the sensor was investigated over a week period, in which 6-7% performance degradation was recorded based on resistance measurement in flat state, whereas no further significant loss was noted over the same period in bending state. The IDE sensor was tested using chronoamperometry with varied glucose concentrations up to 30 mM, resulted in a stabilized current after 5 s. The sensitivity plot attained depicted a best linear fit of 0.988 obtained at response time of 60 s, while covering lowest detection at 0.05 mM. The application of this sensor could contribute as an alternative method to develop a reliable and economical glucose sensing wearable for independent monitoring.

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Metal/Metal Oxide Modified Graphene Nanostructures for Electrical Biosensing Applications: A Review

Cited by 11 publications

References 159 publications

Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode

Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode

Development of an Electrochemical Dopamine Sensor Using Nitrogen-Rich Sulfur Dual-Doped Reduced Graphene Oxide

Development of Rapid Dispense-Printed Flexible Interdigitated Electrode Modified with rGO-TiO₂ Nanohybrid for Glucose Detection

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Metal/Metal Oxide Modified Graphene Nanostructures for Electrical Biosensing Applications: A Review

Cited by 11 publications

References 159 publications

Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode

Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode

Development of an Electrochemical Dopamine Sensor Using Nitrogen-Rich Sulfur Dual-Doped Reduced Graphene Oxide

Development of Rapid Dispense-Printed Flexible Interdigitated Electrode Modified with rGO-TiO2 Nanohybrid for Glucose Detection

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Product

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Development of Rapid Dispense-Printed Flexible Interdigitated Electrode Modified with rGO-TiO₂ Nanohybrid for Glucose Detection