Metal/Metal Oxide Nanoparticles: Toxicity, Applications, and Future Prospects

Chaudhary, Ratiram Gomaji; Bhusari, Ganesh S.; Tiple, Ashish D.; Alok, R.; Somkuvar, Subhash R.; Potbhare, Ajay K.; Lambat, Trimurti L.; Ingle, Prashant P.; Abdala, Ahmed

doi:10.2174/1381612825666191111091326

Cited by 90 publications

(26 citation statements)

References 175 publications

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“…This results in a change in the surface of the NPs by elevating a variety of electrons and holes, followed by the generation of ROS and oxidative stress, which eventually cause the death of cells. However, the anti-oxidative capability of the cell is surpassed; thus, ZnO NPs would act as a redox system [ 20 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

Greener Synthesis of Zinc Oxide Nanoparticles: Characterization and Multifaceted Applications

et al. 2020

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Nanoparticles (NPs) have unique properties compared to their bulk counterparts, and they have potentials for various applications in many fields of life science. Green-synthesized NPs have garnered considerable interest due to their inherent features such as rapidity, eco-friendliness and cost-effectiveness. Zinc oxide nanoparticles (ZnO NPs) were synthesized using an aqueous extract of Kalanchoe blossfeldiana as a reducing agent. The resulting nanoparticles were characterized via X-ray diffraction (XRD), dynamic light scattering (DLS), UV-Vis spectroscopy, photoluminescence (PL), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS). The antimicrobial potential of the synthesized ZnO NPs against bacterial and fungal strains was examined by the disk diffusion method, and they showed a promising antibacterial and antifungal potential. The catalytic activity of the synthesized ZnO NPs in reducing methylene blue (MB) and eosin was studied via UV-Vis spectroscopy. The decolorization percentages of the MB and Eosin Y dyes were 84% and 94%, respectively, which indicate an efficient degradation of the ZnO NPs. In addition, the cytotoxic activity of the ZnO NPs on the HeLa cell line was evaluated via in vitro assay. The MTT assay results demonstrate a potent cytotoxic effect of the ZnO NPs against the HeLa cancer cell line.

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Section: Resultsmentioning

confidence: 99%

Greener Synthesis of Zinc Oxide Nanoparticles: Characterization and Multifaceted Applications

et al. 2020

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“…The strong binding of NPs to outer membrane of bacteria results in inhibition of active transport andenzymatic activity, which cause oxidative stress and eventually results in cell lysis (Govindarajan et al, 2019; Karthik et al, 2014; Potbhare et al, 2019). Microbial synthesized CdO NPs inactivate the proteins due to occurrence of organic compounds on the outer layer of NPs, decreasing the membrane permeability and ultimately causing the cellular death (Ratiram G Chaudhary et al, 2019). It Hence, CdO NPs are proposed to be used in pathogenic bacteria resistant to traditional antibiotics due to their inhibitory effects.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of microbial mediated cadmium oxide nanoparticles

Asghar

Habib

Zaman

et al. 2020

Microscopy Res & Technique

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Microbial mediated synthesis of metallic nanoparticles constitutes as effective and promising approach for the development of antibacterial materials in the field of bioengineering and biomedicine. We prepared Cadmium oxide nanoaprticles (CdO NPs) utilizing Penicillium oxalicum, and cadmium acetate solution via coprecipitate method. The elemental composition and morphology of these synthesized CdO NPs were examined through X-ray diffraction (XRD), UV-Vis absorption spectroscopy, Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM), and Energy dispersive spectroscopy (EDS). Furthermore, we evaluated the bactericidal potential of prepared CdO NPs using Escherichia coli (E.coli), Staphylococcus aureus (S.aureus), Bacillus cereus (B.cereus), and Pseudomonas aeruginosa (P. aeruginosa). Dimethyl sulfoxide was used as negative control while erythromycin was used as positive control. The XRD spectrum revealed cubic crystalline nanoparticles with 22.94 nm size and UV showed absorbance peak at 297 nm with 2.5 eV band gap energy. FTIR depicted O─H and carboxylic groups along with CdO stretching vibration. EDS showed the presence of organic compounds on Cd and O over NPs surface. SEM results revealed the spherical shape of the CdO NPs. The synthesized NPs exhibited highly potent bactericidal activity against selected strains and demonstrated less optical density of 0.086 after 24 hr. Owing to the significant antibacterial activity of CdO NPs, the broad application prospects of these nanoparticles CdO NPs in extensive biomedical applications is indicated.

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“…Although, several metallic nanoantibiotics were found having great potential either to cease or eradicate biofilm adherence [37]. Whereas, the propensity of nanoantibiotics to readily diffuse through the biofilm biomass in order to reach microbial cells seemed to be compromised due to enzymatic, non-enzymatic and pH mediated degradations [38]. Interestingly, the evidence suggests that FAs, either free or physisorbed on to surface of NPs can (i) suppress the regulation of quorum-sensing (QS) genes, (ii) quenched the diffusible QS signal factors such as acyl-homoserine lactones and autoinducer-2 (AI-2) and (iii) dysregulate the associated non-QS targets like efflux pumps, oxidative stress and ergosterol synthesis [39][40][41].…”

Section: Antibiofilm Studies Of Liv-agnpsmentioning

confidence: 99%

Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents

et al. 2021

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The current study demonstrates the synthesis of fatty acids (FAs) capped silver nanoparticles (AgNPs) using aqueous poly-herbal drug Liv52 extract (PLE) as a reducing, dispersing and stabilizing agent. The NPs were characterized by various techniques and used to investigate their potent antibacterial, antibiofilm, antifungal and anticancer activities. GC-MS analysis of PLE shows a total of 37 peaks for a variety of bio-actives compounds. Amongst them, n-hexadecanoic acid (21.95%), linoleic acid (20.45%), oleic acid (18.01%) and stearic acid (13.99%) were found predominately and most likely acted as reducing, stabilizing and encapsulation FAs in LIV-AgNPs formation. FTIR analysis of LIV-AgNPs shows some other functional bio-actives like proteins, sugars and alkenes in the soft PLE corona. The zone of inhibition was 10.0 ± 2.2–18.5 ± 1.0 mm, 10.5 ± 2.5–22.5 ± 1.5 mm and 13.7 ± 1.0–16.5 ± 1.2 against P. aeruginosa, S. aureus and C. albicans, respectively. LIV-AgNPs inhibit biofilm formation in a dose-dependent manner i.e., 54.4% ± 3.1%—10.12% ± 2.3% (S. aureus), 72.7% ± 2.2%–23.3% ± 5.2% (P. aeruginosa) and 85.4% ± 3.3%–25.6% ± 2.2% (C. albicans), and SEM analysis of treated planktonic cells and their biofilm biomass validated the fitness of LIV-AgNPs in future nanoantibiotics. In addition, as prepared FAs rich PLE capped AgNPs have also exhibited significant (p < 0.05 *) antiproliferative activity against cultured HCT-116 cells. Overall, this is a very first demonstration on employment of FAs rich PLE for the synthesis of highly dispersible, stable and uniform sized AgNPs and their antibacterial, antifungal, antibiofilm and anticancer efficacy.

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Metal/Metal Oxide Nanoparticles: Toxicity, Applications, and Future Prospects

Cited by 90 publications

References 175 publications

Greener Synthesis of Zinc Oxide Nanoparticles: Characterization and Multifaceted Applications

Greener Synthesis of Zinc Oxide Nanoparticles: Characterization and Multifaceted Applications

Synthesis and characterization of microbial mediated cadmium oxide nanoparticles

Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents

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