Metal nanoclusters: novel probes for diagnostic and therapeutic applications

Tao, Yu; Li, Mingqiang; Ren, Jinsong; Qu, Xiaogang

doi:10.1039/c5cs00607d

Cited by 660 publications

(343 citation statements)

References 253 publications

(244 reference statements)

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“…However, to the best of our knowledge, the therapeutic strategies for TNBC on previous studies are lack of imaging guidance. For photothermal‐chemical combination therapy of TNBC, imaging‐guided therapy has several advantages to improve the therapeutic efficacy 17, 18, 19, 20, 21, 22, 23, 24, 25. First, imaging could provide the information of the tumor's shape, size, location, and relationship with surrounding tissues, which is helpful for determining treatment position and scope.…”

Section: Introductionmentioning

confidence: 99%

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

Tian

et al. 2016

Advanced Science

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Complete eradication of highly aggressive triple negative breast cancer (TNBC) remains a notable challenge today. In this work, an imaging‐guided photothermal‐chemotherapy strategy for TNBC is developed for the first time based on a periodic mesoporous organosilica (PMO) coated Prussian blue (PB@PMO) nanoplatform. The PB@PMOs have organic‐inorganic hybrid frameworks, uniform diameter (125 nm), high surface area (866 m2 g−1), large pore size (3.2 nm), excellent photothermal conversion capability, high drug loading capacity (260 µg mg−1), and magnetic resonance (MR) and photoacoustic (PA) imaging abilities. The MR and PA properties of the PB@PMOs are helpful for imaging the tumor and showing the accumulation of the nanoplatform in the tumor region. The bioluminescence intensity and tumor volume of the MDA‐MB‐231‐Luc tumor‐bearing mouse model demonstrate that TNBC can be effectively inhibited by the combined photothermal‐chemotherapy than monotherapy strategy. Histopathological analysis further reveals that the combination therapy results in most extensive apoptotic and necrotic cells in the tumor without inducing obvious side effect to major organs.

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Section: Introductionmentioning

confidence: 99%

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

Tian

et al. 2016

Advanced Science

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“…Furthermore, we have also reported the detection of 2, 4-Dinitrotoluene using Ag-Au nanostructures achieved using femtosecond laser ablation [13]. Recently, composite nanoparticles have attracted much attention by physicists, chemists and material scientists due to their higher catalytic, electronic, optical, physicochemical properties and multiple functionalities [2,[27][28][29][30][31][32][33][34]. To fabricate bimetallic/alloy NPs, there are several ways or (a) short pulse laser irradiation of colloidal mixture of NPs (b) ablation of a target in the presence of a precursor solution or (c) short pulse laser irradiation of alloy target in liquid media etc.…”

Section: Introductionmentioning

confidence: 99%

Femtosecond Laser Fabricated Ag@Au and Cu@Au Alloy Nanoparticles for Surface Enhanced Raman Spectroscopy Based Trace Explosives Detection

2018

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Herein we present results from our detailed studies on the fabrication of Ag@Au and Cu@Au alloy nanoparticles (NPs) using the femtosecond laser ablation in liquid technique. The NPs were obtained by ablating the pure Ag, Cu targets (bulk) in HAuCl 4 (5 mM) solution. The absorption properties of the obtained NPs colloids were characterized using UV-Visible absorption spectrometer and their size, shape, and crystallinity were investigated using the XRD, FESEM and TEM techniques. The fabricated NPs were utilized for sensing of explosive molecules such as 2,4,6-trinitrophenol (PA), 2,4-dinitrotoluene (DNT) and a common dye methylene blue (MB) using the surface enhanced Raman spectroscopy (SERS) technique. The detection limit in terms of weight was as low as few nano-grams in the case of nitroaromatic explosive compounds (PA, DNT) and few picograms in the case of a common dye molecule (MB). Typical enhancement factors achieved were estimated to be ∼10 4 , ∼10 5 , and ∼10 7 , respectively, for PA, DNT, and MB. The significance of the present work lies in exploring the performance of the prepared NPs being used as SERS substrates for explosives detection using a portable Raman instrument. Such capability enables one to carry the spectrometer to the point of interest in the field and evaluate any hazardous samples within a short period of time.

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“…This triggered an ongoing search for alternative, rare‐earth free phosphors for WLEDs 8, 9. Among them, metal nanoclusters (NCs)9, 10 are attractive, as they can be easily synthesized in solution, processed into powders, and, for the noble metal NCs, exhibit strong PL with a large Stokes shift 11. Copper is an earth abundant element widely used in different industries, and there have been few reports on down‐conversion WLEDs with Cu NCs as phosphors, mostly in combination with other luminophores 9.…”

Section: Introductionmentioning

confidence: 99%

All‐Copper Nanocluster Based Down‐Conversion White Light‐Emitting Devices

et al. 2016

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Most of the present‐day down‐conversion white light‐emitting devices (WLEDs) utilize rare‐earth elements, which are expensive and facing the problem of shortage in supply. WLEDs based on the combination of orange and blue emitting copper nanoclusters are introduced, which are easy to produce and low in cost. Orange emitting Cu nanoclusters (NCs) are synthesized using glutathione as both the reduction agent and stabilizer, followed by solvent induced aggregation leading to the emission enhancement. Photoluminescence quantum yields (PL QY) of 24% and 43% in solution and solid state are achieved, respectively. Blue emitting Cu nanoclusters are synthesized by reduction of polyvinylpyrrolidone supported Cu(II) ions using ascorbic acid, followed by surface treatment with sodium citrate which improves both the emission intensity and stability of the clusters, resulting in the PL QY of 14% both in solution and solid state. All‐copper nanocluster based down‐conversion WLEDs are fabricated by integrating powdered orange and blue emitting Cu NC samples on a commercial GaN LED chip providing 370 nm excitation. They show favorable white light characteristics with Commission Internationale de l'Eclairage color coordinates, color rendering index, and correlated color temperature of (0.36, 0.31), 92, and 4163 K, respectively.

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Metal nanoclusters: novel probes for diagnostic and therapeutic applications

Cited by 660 publications

References 253 publications

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

Periodic Mesoporous Organosilica Coated Prussian Blue for MR/PA Dual‐Modal Imaging‐Guided Photothermal‐Chemotherapy of Triple Negative Breast Cancer

Femtosecond Laser Fabricated Ag@Au and Cu@Au Alloy Nanoparticles for Surface Enhanced Raman Spectroscopy Based Trace Explosives Detection

All‐Copper Nanocluster Based Down‐Conversion White Light‐Emitting Devices

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