Metal Nanoparticles: Advanced and Promising Technology in Diabetic Wound Therapy

Abstract

Diabetic wounds pose a significant challenge to public health, primarily due to insufficient blood vessel supply, bacterial infection, excessive oxidative stress, and impaired antioxidant defenses. The aforementioned condition not only places a significant physical burden on patients’ prognosis, but also amplifies the economic strain on the medical system in treating diabetic wounds. Currently, the effectiveness of available treatments for diabetic wounds is limited. However, there is hope in the potential of metal nanoparticles (MNPs) to address these issues. MNPs exhibit excellent anti-inflammatory, antioxidant, antibacterial and pro-angiogenic properties, making them a promising solution for diabetic wounds. In addition, MNPs stimulate the expression of proteins that promote wound healing and serve as drug delivery systems for small-molecule drugs. By combining MNPs with other biomaterials such as hydrogels and chitosan, novel dressings can be developed and revolutionize the treatment of diabetic wounds. The present article provides a comprehensive overview of the research progress on the utilization of MNPs for treating diabetic wounds. Building upon this foundation, we summarize the underlying mechanisms involved in diabetic wound healing and discuss the potential application of MNPs as biomaterials for drug delivery. Furthermore, we provide an extensive analysis and discussion on the clinical implementation of dressings, while also highlighting future prospects for utilizing MNPs in diabetic wound management. In conclusion, MNPs represent a promising strategy for the treatment of diabetic wound healing. Future directions include combining other biological nanomaterials to synthesize new biological dressings or utilizing the other physicochemical properties of MNPs to promote wound healing. Synthetic biomaterials that contain MNPs not only play a role in all stages of diabetic wound healing, but also provide a stable physiological environment for the wound-healing process.

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

“…In contrast, collagen deposition, increased M2 macrophages, upregulation of angiogenic factor expression and endothelial cell proliferation are favorable factors. These conditions interact with each other to regulate the wound healing process . DFU is a classic example of wounds with chronic persistent inflammatory wound trauma and a complex microenvironment where the clinical healing period typically lasts more than 4 weeks .…”

“…Comparison of factors that promote and delay wound healing. ref . Originally published by and used with permission from Dove Medical Press Ltd., 2024.…”

“…These conditions interact with each other to regulate the wound healing process. 41 DFU is a classic example of wounds with chronic persistent inflammatory wound trauma and a complex microenvironment where the clinical healing period typically lasts more than 4 weeks. 42 In this section, several typical features of the DFU microenvironment, such as hyperglycemia, hyperinflammation, and high proteases, will be categorized and discussed so as to gain insights into the causes of DFU and factors affecting healing.…”

The biological synthesis, characterization, and therapeutic utility of Fusarium oxysporum silver nanoparticles

“…Silver nanoparticles have shown potential in reducing in ammation. Silver nanoparticles (AgNPs) have shown signi cant potential in reducing in ammation, a bene cial property that can be leveraged in various medical applications [75][76][77][78][79][80].…”

Biochemical Behavior, Influence on Cell DNA Condition, and Microbiological Properties of Wool and Wool–Copper Materials

“…Subsequent wound healing of the skin [ 2 ] presents a very complex biological process [ 3 , 4 , 5 ], and thus, its effective treatment has become one of the most important challenges for healthcare [ 6 , 7 , 8 , 9 , 10 , 11 ]. Therefore, various wound dressings have been tested [ 12 , 13 , 14 , 15 , 16 ], among them polymer composites exhibiting effective hemostatic [ 17 , 18 , 19 ] and antibacterial properties [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”