Metal nanoparticles in the template of poly(2-ethyl-2-oxazoline)-block-poly(ε-caprolactone) micelle

Park, Chi Young; Rhue, Mi Kyo; Lim, Ji No; Kim, Chul-Hee

doi:10.1007/bf03218750

Cited by 17 publications

(9 citation statements)

References 26 publications

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“…The adsorption of the dispersed silk fibroin onto the surface of the self-assembled micelles would increase the diameter of the micelles. 15 Synchronously, the agglomeration of the free silk fibroin would also lead to the formation of filaments between pairs of micelles.…”

Section: Resultsmentioning

confidence: 99%

pH-Triggered transition of silk fibroin from spherical micelles to nanofibrils in water

et al. 2008

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Many natural proteins self-assemble in complex ways, either to fulfill their biological function or introduce particular properties, such as high strength and toughness. We report the morphological transition in water from a spherical to rod-like shape of Bombyx mori silk fibroin by reducing the pH. Transmission electron microscopy, scanning electron microscopy, and dynamic light scattering were used to characterize the dilute solutions of silk fibroin in an aqueous environment, and provide direct visualization of the transformation of spherical micelles at pH 6.8 to nanofibrils at pH 4.8. This change in morphology occurred as a result of the stretching entropy due to the formation of β-sheets, which was analyzed using circular dichroism spectroscopy. This study demonstrates the selfassembly of silk fibroin as a function of pH.

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Section: Resultsmentioning

confidence: 99%

pH-Triggered transition of silk fibroin from spherical micelles to nanofibrils in water

et al. 2008

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“…The size of the nanoparticle and the interspacing between the particles can be easily controlled by adjusting the length and volume fraction of each block. [80][81][82][83][84][85][431][432][433][434][435] Three different approaches have been developed to fabricate 2-D arrays of nanoparticles by using the micellar templates. First, metal ions are selectively loaded to one of the blocks of block copolymer in solution and spin coated on solid substrates to obtain monolayer thin film.…”

Section: Block Copolymers In Thin Filmsmentioning

confidence: 99%

Self-assembled block copolymers: Bulk to thin film

2008

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Block copolymers that two or more polymer chains are covalently linked have drawn much attention due to self-assembly into nanometer-sized morphology such as lamellae, cylinders, spheres, and gyroids. In this article, we first summarize the phase behavior of block copolymers in bulk and thin films and some applications for new functional nanomaterials. Then, future perspectives on block copolymers are described.

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“…[21][22][23] A great deal of different strategies for modification of these polymeric materials has been also intensively reported with the aim of fine-tuning of physicochemical properties on demand for practical applications by means of (i) chemically conjugation through copolymerization with poly(ethylene glycol) (PEG) [24][25][26][27] or biologically benign moieties, [28][29][30][31] and (ii) surface modification via surface coating, [32][33][34] blend, 35,36 and plasma treatment. 37 Those modifications make it possible to readily tailor the hydrophilicity, 32,35 specific interaction, 32,37 and other desired functions.…”

Section: Introductionmentioning

confidence: 99%

Formation of poly(ethylene glycol)-poly(ε-caprolactone) Nanoparticles via Nanoprecipitation

et al. 2009

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Size control of therapeutic carriers in drug delivery systems has become important due to its relevance to biodistribution in the human body and therapeutic efficacy. To understand the dependence of particle size on the formation condition during nanoprecipitation method, we prepared nanoparticles from biodegradable, amphiphilic block copolymers and investigated the particle size and structure of the resultant nanoparticles according to various process parameters. We synthesized monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) block copolymer, MPEG-PCL, with different MPEG/PCL ratios via ring opening polymerization initiated from the hydroxyl end group of MPEG. Using various formulations with systematic change of the block ratio of MPEG and PCL, solvent choice, and concentration of organic phase, MPEG-PCL nanoparticles were prepared through nanoprecipitation technique. The results indicated that (i) the nanoparticles have a dual structure with an MPEG shell and a PCL core, originating from self-assembly of MPEG-PCL copolymer in aqueous condition, and (ii) the size of nanoparticles is dependent upon two sequential processes: diffusion between the organic and aqueous phases and solidification of the polymer.

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Metal nanoparticles in the template of poly(2-ethyl-2-oxazoline)-block-poly(ε-caprolactone) micelle

Cited by 17 publications

References 26 publications

pH-Triggered transition of silk fibroin from spherical micelles to nanofibrils in water

pH-Triggered transition of silk fibroin from spherical micelles to nanofibrils in water

Self-assembled block copolymers: Bulk to thin film

Formation of poly(ethylene glycol)-poly(ε-caprolactone) Nanoparticles via Nanoprecipitation

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