Metal Nanoparticles/Porous Silicon Microcavity Enhanced Surface Plasmon Resonance Fluorescence for the Detection of DNA

Wang, Jiajia; Jia, Zhenhong

doi:10.3390/s18020661

Cited by 24 publications

(17 citation statements)

References 33 publications

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“…This sensor was able to detect benzene-thiol binding to the gold nanoparticles both interferometrically and by means of SERS. In addition, optical sensors based on porous silicon microcavities decorated with gold nanoparticles have been used to detect DNA by surface enhanced fluorescence (Wang and Jia, 2018).…”

Section: Introductionmentioning

confidence: 99%

One Spot—Two Sensors: Porous Silicon Interferometers in Combination With Gold Nanostructures Showing Localized Surface Plasmon Resonance

2019

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Sensors composed of a porous silicon monolayer covered with a film of nanostructured gold layer, which provide two optical signal transduction methods, are fabricated and thoroughly characterized concerning their sensing performance. For this purpose, silicon substrates were electrochemically etched in order to obtain porous silicon monolayers, which were subsequently immersed in gold salt solution facilitating the formation of a porous gold nanoparticle layer on top of the porous silicon. The deposition process was monitored by reflectance spectroscopy, and the appearance of a dip in the interference pattern of the porous silicon layer was observed. This dip can be assigned to the absorption of light by the deposited gold nanostructures leading to localized surface plasmon resonance. The bulk sensitivity of these sensors was determined by recording reflectance spectra in media having different refractive indices and compared to sensors exclusively based on porous silicon or gold nanostructures. A thorough analysis of resulting shifts of the different optical signals in the reflectance spectra on the wavelength scale indicated that the optical response of the porous silicon sensor is not influenced by the presence of a gold nanostructure on top. Moreover, the adsorption of thiol-terminated polystyrene to the sensor surface was solely detected by changes in the position of the dip in the reflectance spectrum, which is assigned to localized surface plasmon resonance in the gold nanostructures. The interference pattern resulting from the porous silicon layer is not shifted to longer wavelengths by the adsorption indicating the independence of the optical response of the two nanostructures, namely porous silicon and nanostructured gold layer, to refractive index changes and pointing to the successful realization of two sensors in one spot.

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Section: Introductionmentioning

confidence: 99%

One Spot—Two Sensors: Porous Silicon Interferometers in Combination With Gold Nanostructures Showing Localized Surface Plasmon Resonance

2019

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“…The next trend arises from analyte nature, and demonstrates that the increase in complexity of analytes requires more complicated substrates and procedures. This can be traced from the simple metal films and nanoparticles used for small organic molecules and proteins [ 18 , 22 , 34 , 39 , 58 , 60 ] to the complicated plasmonic chips, platforms, nanostructures, and quantum dots used for DNA sensing and detection of antibodies, toxins, and bacteria [ 77 , 82 , 94 , 97 , 99 , 101 ]. Furthermore, the last trend, arising from the differences between substrates and their increasing level of sophistication, states the following: the increase in the complexity of the substrate leads to better sensitivity and consequently, a lower limit of detection.…”

Section: Discussion Of Trendsmentioning

confidence: 99%

“…They concluded with a proposition for the use of their modified substrate for other biomarkers and proteins. Last but not least, the group led by Dr. Jia published a research paper in 2018 on the detection of DNA marked with rhodamine dye using a porous silicon microcavity substrate embedded with gold nanoparticles [ 94 ]. The limit of detection was estimated to be 10 pM, with a concentration range spanning from 100 nM to 10 μM, and a positive correlation coefficient of 0.98.…”

Section: Dna Rna and Oligonucleotidesmentioning

confidence: 99%

Review: Applications of surface-enhanced fluorescence (SEF) spectroscopy in bio-detection and biosensing

Sultangaziyev

Bukasov

2020

Sensing and Bio-Sensing Research

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Surface-enhanced fluorescence (SEF) is rapidly becoming one of the main spectroscopic techniques for the detection of a variety of biomolecules and biomarkers. The main reasons for this trend are the high sensitivity and selectivity, robustness, and speed of this analytical method. Each year, the number of applications that utilize this phenomenon increases and with each such work, the complexity and novelty of the used substrates, procedures, and analytes rises. To obtain a clearer view of this phenomenon and research area, we decided to combine 76 valuable research articles from a variety of different research groups into this mini-review. We present and describe these works concisely and clearly, with a particular interest in the quantitative parameters of the experiment. These sources are classified according to the nature of the analyte, on the contrary to most reviews, which sort them by substrate nature. This point of view gives us insight into the development of this research area and the consequent increase in the complexity of the analyte nature. Moreover, this type of sorting can show possible future routes for the expansion of this research area. Along with the analytes, we can also pay attention to the substrates used for each situation and how the development of substrates affects the direction of research and subsequently, the choice of an analyte. About 108 sources and several interesting trends in the SEF research area over the past 25 years are discussed in this mini-review.

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“…Furthermore, Ag nanostructures in SiO 2 /psilicon is found as SERS active substrate in a broad spectral range [87]. Au nanoparticles modified porous silicon shows a strong fluorescence enhancement due to plasmon resonance which is used for highly sensitive DNA detection [88]. Porous silicon with a Au nanoparticle layer on top offers light absorption by the Au particles leading to localized surface plasmon resonance.…”

Section: Optical Properties Of Metal Filled Mesoporous Siliconmentioning

confidence: 99%

Metal Filled Nanostructured Silicon With Respect to Magnetic and Optical Properties

Granitzer

Rumpf

2020

Front. Phys.

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Within this work the utilization of nanostructured silicon as host material for filling with various magnetic nanostructures is reviewed whereas the magnetic and optical properties of the gained composite systems are elucidated. The metal filling of the pores is mainly performed by electroless deposition or by electrodeposition which is discussed by means of some examples. Furthermore, two different types of porous silicon (PSi) morphology are used for the deposition procedure. On the one hand microporous silicon offering luminescence in the visible range is utilized as template material. It offers a branched morphology with a structure size between 2 and 5 nm. In this case not only the magnetic response is investigated but also the influence of the metal filling on the optical properties. On the other hand mesoporous and macroporous silicon in it's low pore regime is employed which offers straight pores with diameters up to 90 nm. In this case the magnetic response strongly depends on the size, the geometry and the spatial distribution of the metal deposits within the pores. A crucial role plays also the morphology of the porous silicon, especially the distance between adjacent pores which is an important parameter regarding magnetic interactions.

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Metal Nanoparticles/Porous Silicon Microcavity Enhanced Surface Plasmon Resonance Fluorescence for the Detection of DNA

Cited by 24 publications

References 33 publications

One Spot—Two Sensors: Porous Silicon Interferometers in Combination With Gold Nanostructures Showing Localized Surface Plasmon Resonance

One Spot—Two Sensors: Porous Silicon Interferometers in Combination With Gold Nanostructures Showing Localized Surface Plasmon Resonance

Review: Applications of surface-enhanced fluorescence (SEF) spectroscopy in bio-detection and biosensing

Metal Filled Nanostructured Silicon With Respect to Magnetic and Optical Properties

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