Metal–organic framework based antibiotic release and antimicrobial response: an overview

Kaur, Navdeep; Tiwari, Pranav; Kapoor, Kshipra; Saini, Anoop Kumar; Sharma, Vinay; Mobin, Shaikh M.

doi:10.1039/d0ce01215g

Cited by 63 publications

(34 citation statements)

References 188 publications

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“…Both temperature and pressure is known to play an important role in both drug solubility in a solvent as well as in its loading and drug release. 62,63 The study of dependence of drug uptake on pressure is important as it may allow us to tune the amount of drug adsorbed in MOFs by simply tuning the surrounding pressure. 62 As we have used three MOFs and three drugs with different stability and solubility, respectively, we have used a wide range of pressure to study drug adsorption.…”

Section: (B)(i))mentioning

confidence: 99%

Modelling drug adsorption in metal–organic frameworks: the role of solvent

et al. 2021

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Section: (B)(i))mentioning

confidence: 99%

Modelling drug adsorption in metal–organic frameworks: the role of solvent

et al. 2021

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“…Polymeric nanofibers and hydrogels are beneficial for the long-term release of antimicrobial agents and wound coverage [41,42]. Very recently, metal organic frameworks (MOFs) have attracted attention as emerging carriers for the efficient delivery of metal ions, metal nanoparticles, antibiotics and enzymes due to their highly porous structures [43][44][45][46]. There are several advantages of using polymeric nanomaterials as carriers to accomplish the on-demand delivery of antimicrobial agents: (i) reduced dosage and drug resistance; (ii) increased in vivo circulation stability; (iii) enhanced penetration ability; (iv) prolonged antimicrobial performance; and (v) improved bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Polymeric Nanomaterials for Efficient Delivery of Antimicrobial Agents

Yin

Sun

2021

Pharmaceutics

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Bacterial infections have threatened the lives of human beings for thousands of years either as major diseases or complications. The elimination of bacterial infections has always occupied a pivotal position in our history. For a long period of time, people were devoted to finding natural antimicrobial agents such as antimicrobial peptides (AMPs), antibiotics and silver ions or synthetic active antimicrobial substances including antimicrobial peptoids, metal oxides and polymers to combat bacterial infections. However, with the emergence of multidrug resistance (MDR), bacterial infection has become one of the most urgent problems worldwide. The efficient delivery of antimicrobial agents to the site of infection precisely is a promising strategy for reducing bacterial resistance. Polymeric nanomaterials have been widely studied as carriers for constructing antimicrobial agent delivery systems and have shown advantages including high biocompatibility, sustained release, targeting and improved bioavailability. In this review, we will highlight recent advances in highly efficient delivery of antimicrobial agents by polymeric nanomaterials such as micelles, vesicles, dendrimers, nanogels, nanofibers and so forth. The biomedical applications of polymeric nanomaterial-based delivery systems in combating MDR bacteria, anti-biofilms, wound healing, tissue engineering and anticancer are demonstrated. Moreover, conclusions and future perspectives are also proposed.

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“…Gradual degradation of the MOFs skeleton structure slowly releases metal ions like Ag, Zn, Cu, Ni, etc., to exhibit a sustained antibacterial effect. − The organic ligands/linkers in MOFs may also possess antibacterial activity. Sometimes prodrugs can be used as ligands to construct the MOF or a postsynthetic modification of the ligand is performed to load the antibacterial agent . Moreover, MOFs can store antibacterial substances within the pores.…”

Section: Introductionmentioning

confidence: 99%

Smart Metal–Organic Frameworks for Biotechnological Applications: A Mini-Review

Chattopadhyay

Mandal

Maiti

2021

ACS Appl. Bio Mater.

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In this pandemic situation it is evident that viruses and bacteria, more specifically, multiple drug resistant (MDR) bacteria, endanger human civilization severely. It is high time to design smart weapons to combat these pathogens for the prevention and cure of allied ailments. Metal–organic frameworks (MOFs) are porous materials designed from metal ions or inorganic clusters and multidentate organic ligands. Due to some unique features like high porosity, tunable pore shape and size, numerous possible metal-ligand combinations, etc., MOFs are ideal candidates to design “smart biotechnological tools”. MOFs construct promising fluorescence based biosensing platforms for detection of viruses. MOFs also exhibit excellent antibacterial activity due to their ability for sustained release of active biocidal agents. There are several reviews that summarize the antibacterial applications of MOFs, but the biosensing platforms based on MOFs for detection of viruses have scarcely been summarized. This review carefully covers both the aspects including virus detection (nucleic acid recognition and immunological detection) with underlying mechanisms as well as antibacterial application of MOFs and doped MOFs or composites. This review will deliver valuable information and references for designing new, smarter antimicrobial agents based on MOFs.

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Metal–organic framework based antibiotic release and antimicrobial response: an overview

Abstract: Metal–organic frameworks (MOFs) are percolative crystalline material in which multidentate organic ligands and transition metal cations are linked via coordination bonds. The porosity of MOFs enables them to be used...

Cited by 63 publications

References 188 publications

Modelling drug adsorption in metal–organic frameworks: the role of solvent

Modelling drug adsorption in metal–organic frameworks: the role of solvent

Polymeric Nanomaterials for Efficient Delivery of Antimicrobial Agents

Smart Metal–Organic Frameworks for Biotechnological Applications: A Mini-Review

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