Metal-Organic-Framework FeBDC-Derived Fe3O4 for Non-Enzymatic Electrochemical Detection of Glucose

Abstract

Present-day science indicates that developing sensors with excellent sensitivity and selectivity for detecting early signs of diseases is highly desirable. Electrochemical sensors offer a method for detecting diseases that are simpler, faster, and more accurate than conventional laboratory analysis methods. Primarily, exploiting non-noble-metal nanomaterials with excellent conductivity and large surface area is still an area of active research due to its highly sensitive and selective catalysts for electrochemical detection in enzyme-free sensors. In this research, we successfully fabricate Metal-Organic Framework (MOF) FeBDC-derived Fe3O4 for non-enzymatic electrochemical detection of glucose. FeBDC synthesis was carried out using the solvothermal method. FeCl2.4H2O and Benzene-1,4-dicarboxylic acid (H2BDC) are used as precursors to form FeBDC. The materials were further characterized utilizing X-ray Powder Diffraction (XRD), Scanning Electron Microscopy (SEM), and Fourier-Transform Infrared Spectroscopy (FTIR). The resulting MOF yields good crystallinity and micro-rod like morphology. Electrochemical properties were tested using Cyclic Voltammetry (CV) and Differential Pulse Voltammetry (DPV) with a 0.1 M of Phosphate Buffer Saline (PBS pH 7.4) solution as the supporting electrolyte. The measurement results show the reduction and oxidation peaks in the CV curve of FeBDC, as well as Fe3O4. Pyrolysis of FeBDC to Fe3O4 increases the peak of oxidation and reduction currents. The Fe3O4 sample obtained has a sensitivity of 4.67 µA mM−1.cm−2, a linear range between 0.0 to 9.0 mM, and a glucose detection limit of 15.70 µM.

Recent Advances in Non-Enzymatic Glucose Sensors Based on Metal and Metal Oxide Nanostructures for Diabetes Management- A Review

“…The glucose detection occurred at a neutral pH of 7.4 and showed a LOD of 0.3 μM. In another study by Abrori et al (2020) , Fe 3 O 4 based NEGS was developed that could electrochemically detect glucose molecules and displayed a high sensitivity of 4.67 μA mM −1 cm −2 and a LOD of 15.70 μM. The sensor displayed a high sensitivity and selectivity for glucose molecules.…”

Glucose Detection Devices and Methods Based on Metal–Organic Frameworks and Related Materials

“…This improved performance can be attributed to the existence of abundant channels into the composites, which improved both the adsorption and diffusion of glucose on the catalytic sites. A variety of other MO's nanocomposites derived from MOF [ 112,113,122–131,114,132–141,115,142–145,116–121 ] were developed for glucose sensing and Table 3 summarized their composition and relevant analytical performance.…”

“…[113] The CuO/NiO-C composites showed even a lower LOD (37 nm) with a sensitivity of 586.7 µA cm −2 /× 10 −3 m. This improved performance can be attributed to the existence of abundant channels into the composites, which improved both the adsorption and diffusion of glucose on the catalytic sites. A variety of other MO's nanocomposites derived from MOF [112,113,[122][123][124][125][126][127][128][129][130][131]114,[132][133][134][135][136][137][138][139][140][141]115,[142][143][144][145][116][117][118][119][120][121] were developed for glucose sensing and Table 3 summarized their composition and relevant analytical performance.…”

Metal–Organic-Framework- and MXene-Based Taste Sensors and Glucose Detection

“…In addition to Cu, Ni, Co-based MOFs, and Fe-MOFs are promising materials for efficient glucose determination. For instance, Abrori et al used Fe-BDC as a sacrificial agent to prepare Fe 3 O 4 for glucose identification using electrochemical methods [89]. This compound displayed a LOD of 15.57 M, high selectivity, and outstanding durability.…”