Metal-organic framework-mediated siRNA delivery and sonodynamic therapy for precisely triggering ferroptosis and augmenting ICD in osteosarcoma

Sun, Ningxiang; Lei, Qingjian; Wu, Meng; Gao, Shijie; Yang, Zhiqiang; Lv, Xuan; Wei, Renxiong; Yan, Feifei; Cai, Lin

doi:10.1016/j.mtbio.2024.101053

Materials Today Bio

2024

DOI: 10.1016/j.mtbio.2024.101053

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Metal-organic framework-mediated siRNA delivery and sonodynamic therapy for precisely triggering ferroptosis and augmenting ICD in osteosarcoma

Ningxiang Sun,

Qingjian Lei,

Meng Wu

et al.

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2024

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Nanoparticle-integrated metal–organic frameworks: a revolution in next-generation drug delivery systems

Alavi,

Koohi

et al. 2024

J. Pharm. Investig.

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Background Nanometal-organic frameworks (nano-MOFs), which exhibit distinctive features, such as controlled release mechanisms, stimuli-responsive behaviors, and sustained drug release profiles, have emerged as promising candidates for next-generation drug delivery systems. Area covered This review outlines the impact of nano-MOFs in biomedical applications, emphasizing their potential for targeted drug delivery through active strategies and their biocompatibility considerations. Expert opinion The versatility and tunability of nano-MOFs pave the way for personalized medicine, allowing tailored formulations to meet individual patient needs. Despite their transformative potential, challenges remain in terms of stability, toxicity assessment, and standardization. As nano-MOFs progress from laboratory research to clinical trials, they present a paradigm shift in drug delivery, offering precision medicine solutions through theranostic platforms. The future holds promise for the use of nano-MOFs to revolutionize drug delivery, ushering in an era of personalized and effective therapeutic interventions.

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Nanoparticle-integrated metal–organic frameworks: a revolution in next-generation drug delivery systems

Alavi,

Koohi

et al. 2024

J. Pharm. Investig.

View full text Add to dashboard Cite

show abstract

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Metal-organic framework-mediated siRNA delivery and sonodynamic therapy for precisely triggering ferroptosis and augmenting ICD in osteosarcoma

Cited by 1 publication

References 59 publications

Nanoparticle-integrated metal–organic frameworks: a revolution in next-generation drug delivery systems

Nanoparticle-integrated metal–organic frameworks: a revolution in next-generation drug delivery systems

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