Metal-organic framework MIL-101(Fe)-NH2 functionalized with different long-chain polyamines as drug delivery system

Almáši, Miroslav; Zeleňák, Vladimı́r; Palotai, Peter; Beňová, Eva; Zeleňáková, A.

doi:10.1016/j.inoche.2018.05.007

Cited by 87 publications

(50 citation statements)

References 20 publications

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“…To ensure the biocompatibility of MOFs, both components of the framework-metal and bridging polydentate ligand-should be nontoxic [6]. Several potential drug carrier candidates are already known [2,3,[7][8][9][10], with one of the promising classes of such MOFs that meet such criteria being based on a combination of cyclodextrin (CD) molecules and an alkali metal. CD is a nontoxic cyclic oligosaccharide consisting of six, seven, eight, or more D-glucopyranose units, traditionally designated as α-, β-, γ-, etc.…”

Section: Introductionmentioning

confidence: 99%

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

et al. 2020

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Cyclodextrin (CD) has been used to prepare biocompatible and nontoxic metal-organic frameworks (MOFs) suitable for biomedical applications as drug carriers. In this study, γ-CD/K-based MOF (γ-CD-MOF-1-α) was synthesized and its stability in various solvents was explored by single-crystal X-ray diffractometry (SCXRD) and powder X-ray diffractometry (PXRD). As a result of solvent-induced phase transformations, two novel crystalline phases of γ-CD-MOF-1 were discovered. The newly formed ε- and δ-phases crystallize in orthorhombic and tetragonal symmetry, respectively. In ε-phase, toluene was determined as a guest molecule by SCXRD. Interactions between γ-cyclodextrin and solvent molecules in ε-phase were evaluated using Hirshfeld surface analysis. The thermal stability of the new crystal forms of γ-CD-MOF-1 was analyzed by differential scanning calorimetry and thermogravimetric analysis.

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Section: Introductionmentioning

confidence: 99%

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

et al. 2020

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“…Subsequent studies revealed controlled release was achievable and even animal studies have been conducted. [21][22][23][24][25][26][27] A common feature of these studies was use of the MOF as a controlled-release vehicle. Controlled-release technologies, most of them polymer-based, are mature as judged by the fact that many over-the-counter drugs are available in both immediate and extended-release forms.…”

Section: Account Synlettmentioning

confidence: 99%

“…This is because the general problem of controlled release is well addressed by existing technologies. [27][28][29][30][31] This is precisely the reason why we were targeting amorphous form delivery as a means to improve drug solubility. At this point, a discussion of the biopharmaceuticals classification system (BCS) will help to set the context for this work.…”

Section: Account Synlettmentioning

confidence: 99%

“…This classification allows a basis for establishing in vitro-in vivo correlations for estimating the oral absorption of the drug. Put in context, the MOF-based controlled drug delivery systems from 2006 to date [24][25][26][27][28][29][30][31] were well-suited for class I and class III drugs, as drugs falling under these classes exhibit high solubility and dissolve very rapidly in the gastrointestinal tract. BCS class II and IV drug delivery using water-stable MOFs as a vehicle had also been demonstrated, 24,32 but this approach did not address the challenges (solubility and dissolution rate) of BCS class II and IV drugs for effective oral delivery.…”

Section: Account Synlettmentioning

confidence: 99%

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Leveraging Framework Instability: A Journey from Energy Storage to Drug Delivery

Suresh

López-Mejías

Roy

et al. 2020

Synlett

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Amorphous pharmaceuticals often suffer from poor physical stability, which can negate their high solubility, fast dissolution rate, and better oral bioavailability vs. crystalline forms. This represents a major hurdle to processing, storage, and delivery of amorphous pharmaceuticals. Several approaches to addressing these problems have been pursued, but there is still a need for a general method for stabilizing the amorphous form. We describe a novel approach using a water-unstable metal-organic framework as a drug delivery vehicle that demonstrates improved amorphous form stability accompanied by remarkably enhanced solubility and a fast dissolution rate. This research project spanned eleven years from conception to realization and dissemination. With origins in understanding the stability or porous solids for energy storage materials, the work also highlights potential of basic science understanding to illuminate new areas of application.

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“…Recently, metal‐organic frameworks (MOFs) has become an area of much interest in making supercapacitors electrode materials. MOFs have already got profound applications in the fields of gas adsorption and storage, sensing of small molecules and metal ions, drug delivery, chemical separation, catalysis . Their highly crystalline and systematic framework arrangement, structural diversity, outstanding porosity and surface area accounts for their high functionality and potential applications.…”

Section: Introductionmentioning

confidence: 99%

Lanthanide (III) Metal‐Organic Frameworks: Syntheses, Structures and Supercapacitor Application

et al. 2019

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Three new lanthanide-MOFs, [(TATMB) 2 Ce 2 ⋅3DMSO-H 2 O]⋅7H 2 O (MOFÀ Ce), [(TATMB) 2 Pr 2 ⋅4DMSO]⋅7H 2 O⋅DMF (MOFÀ Pr) and [(TATMB) 2 Nd 2 ⋅3DMSO⋅H 2 O]⋅6H 2 O (MOFÀ Nd) were synthesized by the reaction of hydrated lanthanide salts and 3,3',3''-((1,3,5triazine-2,4,6-triyl)tris(azanediyl))tribenzoic acid (H 3 TATMB) under solvothermal reaction condition. All MOFs were characterized by standard instrumentation techniques, for example, FT-IR spectroscopy, elemental analysis, etc. The solid-state structures were determined by single-crystal X-ray diffraction analyses. It revealed that all MOFs formed two-dimensional frameworks by the coordination assisted pathway of ligand molecules and lanthanide(III) ions. All MOFs were investigated as supercapacitor electrode material by using the conventional three-electrode method by using TEABF 4 in acetonitrile as electrolyte. It was observed that MOFÀ Ce exhibited a maximum specific capacitance of 572 Fg À 1 at a current density of 1 A g À 1 among all three MOFs. The specific capacitance retention of the material was found to be 81% after successful completion of 5000 charging-discharging cycles. To the best of our knowledge, the specific capacitance of MOFÀ Ce is highest reported for lanthanide MOFs without any redox-active additive until now. Moreover, for the first time, MOFÀ Ce has been used to fabricate a device, which exhibited significant responses for various LED lights and showed a maximum specific capacitance of 88 Fg À 1 at a current density of 2 A g À 1 .

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Metal-organic framework MIL-101(Fe)-NH2 functionalized with different long-chain polyamines as drug delivery system

Cited by 87 publications

References 20 publications

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

Leveraging Framework Instability: A Journey from Energy Storage to Drug Delivery

Lanthanide (III) Metal‐Organic Frameworks: Syntheses, Structures and Supercapacitor Application

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