Metal–organic frameworks for biological applications

Abánades Lázaro, Isabel; Chen, Xu; Ding, Mengli; Eskandari, Arvin; Fairen-Jimenez, David; Giménez-Marqués, Mónica; Gref, Ruxandra; Lin, Wenbin; Luo, Taokun; Forgan, Ross S.

doi:10.1038/s43586-024-00320-8

Nat Rev Methods Primers

2024

DOI: 10.1038/s43586-024-00320-8

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Metal–organic frameworks for biological applications

Isabel Abánades Lázaro,

Xu Chen,

Mengli Ding

et al.

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2024

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Cited by 20 publications

References 246 publications

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Recent Advancement in 2D Metal–Organic Framework for Environmental Remediation: A Review

Lu,

Li,

Chu

et al. 2024

Adv Funct Materials

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In a time characterized by the increasing interest in metal–organic frameworks (MOFs) as widely researched crystalline porous substances geared toward enhancing device and system capabilities across diverse environmental contexts, 2D MOFs emerge as a noteworthy class of nanomaterials that integrate the benefits of 2D structures with the unique characteristics inherent to MOFs. These 2D MOFs possess ultrathin nanosheet configuration, abundant accessible active sites, and remarkable mechanical flexibility. Such distinctive properties differentiate them from bulk MOFs and other 2D materials, offering the potential to instigate novel environmental phenomena and applications. This review focuses on the latest progress in the application of 2D MOFs within essential water‐related ecological fields, including contaminant adsorption, photocatalytic degradation, membrane separation, environmental sensing, and disinfection. A variety of synthesis approaches for 2D MOFs are analyzed, accompanied by a discussion on their effectiveness across different environmental settings. The unique structure and features of 2D MOFs that grant outstanding environmental functionalities are compared with those of bulk MOFs. The environmental ramifications of 2D MOFs are highlighted while outlining future research needs to explore the environmental applications of these innovative materials.

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Recent Advancement in 2D Metal–Organic Framework for Environmental Remediation: A Review

Lu,

Li,

Chu

et al. 2024

Adv Funct Materials

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Iron‐MOFs for Biomedical Applications

Yu,

Lepoitevin,

Serre

2024

Adv Healthcare Materials

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Over the past two decades, iron‐based metal–organic frameworks (Fe‐MOFs) have attracted significant research interest in biomedicine due to their low toxicity, tunable degradability, substantial drug loading capacity, versatile structures, and multimodal functionalities. Despite their great potential, the transition of Fe‐MOFs–based composites from laboratory research to clinical products remains challenging. This review evaluates the key properties that distinguish Fe‐MOFs from other MOFs and highlights recent advances in synthesis routes, surface engineering, and shaping technologies. In particular, it focuses on their applications in biosensing, antimicrobial, and anticancer therapies. In addition, the review emphasizes the need to develop scalable, environmentally friendly, and cost‐effective production methods for additional Fe‐MOFs to meet the specific requirements of various biomedical applications. Despite the ability of Fe‐MOFs–based composites to combine therapies, significant hurdles still remain, including the need for a deeper understanding of their therapeutic mechanisms and potential risks of resistance and overdose. Systematically addressing these challenges could significantly enhance the prospects of Fe‐MOFs in biomedicine and potentially facilitate their integration into mainstream clinical practice.

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MOF‐Based Guided Bone Regeneration Membrane for Promoting Osteogenesis by Regulating Bone Microenvironment through Cascade Effects

Liu,

Xie,

Zhang

et al. 2024

Adv Healthcare Materials

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Regulation of bone microenvironment (BME) including innate pH values and metal ions affects cellular functions and activities of osteoblasts and osteoclasts, thereby significantly influencing the process of bone regeneration. How to achieve multiple effective regulations of the BME through cascade effects via facile material design and fabrication to significantly facilitate osteogenesis remains a challenge. Herein, a facilely‐designed resorbable guided bone regeneration membrane (PCL/DEX@Ca‐Zol) based on a drug‐loaded metal‐organic framework is reported. Thereinto, calcium ions, zoledronic acid, and dexamethasone embedded in the membrane can be responsively released specifically inside bone defect in an acid‐triggered manner to synergistically regulate BME by neutralization of pH value, enhancement of osteogenic differentiation and mineralization, and inhibition of osteoclasts in one‐go. Along with polycaprolactone as a structural support in the membrane for bone regeneration with fully utilized components of the composite membrane material, enhances bone regeneration with minimized side effects is accordingly achieved with the assistance of effective modulation of BME through multiple cascade effects.

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Metal–organic frameworks for biological applications

Cited by 20 publications

References 246 publications

Recent Advancement in 2D Metal–Organic Framework for Environmental Remediation: A Review

Recent Advancement in 2D Metal–Organic Framework for Environmental Remediation: A Review

Iron‐MOFs for Biomedical Applications

MOF‐Based Guided Bone Regeneration Membrane for Promoting Osteogenesis by Regulating Bone Microenvironment through Cascade Effects

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