Metal–Organic Frameworks-Mediated Assembly of Gold Nanoclusters for Sensing Applications

Abstract

Gold nanoclusters (AuNCs) are an emerging type of ultrasmall nanomaterials possessing unique physicochemical characteristics. Metal–organic frameworks (MOFs), a singular kind of porous solid and crystalline material, have attracted tremendous attention in recent years. The combination of AuNCs and MOFs can integrate and improve the prominent properties of both components, such as high catalytic activities, tunable optical properties, good biocompatibility, surface functionality and stability, which make the composites of MOFs and AuNCs promising for sensing applications. This review systematically summarizes the recent progress on the sensing of various analytes via MOFs-mediated AuNCs assemblies based on strategies of luminescence sensing, colorimetric sensing, electrochemiluminescence sensing, and electrochemical and photoelectrochemical sensing. A brief outlook regarding the future development of MOFs-mediated AuNCs assemblies for sensing application is presented as well.

Plasmon-enhanced visible-light photocatalytic antibacterial activity of metal–organic framework/gold nanocomposites

“…Thus, AuNCs are expected to assemble on the outer surface of ZIF-8 through the coordination interaction between the carboxyl group in GSH and Zn 2+ ions in ZIF-8. 48,49 In addition, as shown in Fig. S3, † electrostatic interactions between positively charged AuNR@ZIF-8 and negatively charged AuNCs may also contribute to the formation of nanocomposites.…”

Current trends in the synthesis, characterization and application of metal-organic frameworks

“…The MOF film electrode showed excellent electrochemical performance for glucose detection with a wide linear range of 20 μM to 790 μM and a high sensitivity of 205.1 μA mM −1 cm −2 . 229 Wang et al 256 have systematically summarized the recent progress on the sensing of various analytes via MOFmediated AuNC assemblies based on strategies of luminescence sensing, colorimetric sensing, electrochemiluminescence sensing, and electrochemical and photoelectrochemical sensing and presented a brief outlook regarding the future development of MOF-mediated AuNC assemblies for sensing application (see Fig. 11(a)).…”

Gold Nanocluster-Based Fluorescent Microneedle Platform toward Visual Detection of ATP

“…Herein, we report the establishment of a methacrylated hyaluronic acid (MeHA) hydrogel MN sensing platform based on fluorescent gold nanoclusters (AuNCs) for on-needle capture and detection of ATP. Hyaluronic acid (HA) is a natural biopolymer in organisms and has also been reported as an ideal candidate for engineering swellable hydrogel MN patches for target extraction and detection. , Noble metal nanoclusters have recently emerged as promising fluorescent nanoprobes for biosensing due to their ultrasmall core size (<2 nm), strong photoluminescence, facile availability, and good biocompatibility. − Therefore, we fabricated a ratiometric fluorescent ATP probe (RhE-AuNCs) by covalently conjugating an ATP-specific rhodamine dye (RhE) to green-emitting AuNCs. In the presence of ATP, efficient Förster resonance energy transfer (FRET) between AuNCs and RhE will occur.…”