Metal-organic Frameworks (MOF)-based Novel Electrochemiluminescence Biosensing Platform for Quantification of H₂O₂ Releasing from Tumor Cells

Abstract

廖妮 a,b 钟霞 a 梁文斌 a 袁若 a 卓颖 * ,a ( a 西南大学化学化工学院 发光分析与分子传感教育部重点实验室 重庆 400715) ( b 攀枝花学院生物与化学工程学院 攀枝花 617000) 摘要 本工作借助金属-有机框架(MOF)结构, 通过配位作用实现对电化学发光(ECL)分子的空间有序组装, 获得了高 性能 ECL 新材料, 发展了孔道限域效应和微纳空间 ECL 分子有序组装的协同增强 ECL 新策略. 具体而言, 以非共平面 ECL 分子 1,1,2,2-四(4-羧基苯)乙烯(H4TCPE)为配体采用一步水热法合成了具有优异 ECL 性能的新型 MOF 材料

Quadrilateral Nucleic Acid Frame-Accelerating DNAzyme Walker Kinetics for Biosensing Based on Host–Guest Recognition-Enhanced Electrochemiluminescence

“…Luminphore, as an important electronic-to-optical transducer in the electrochemiluminescence (ECL) system, has been continuously developed by researchers. As a rising star in luminphores, polycyclic aromatic hydrocarbons (PAHs) have been widely involved in the construction of a sensing platform due to their tunable luminous properties, versatile synthesis, and functional flexibility. − However, the weak and unstable response of PAHs in aqueous solution slows down their progress in the field of ECL bioanalysis. So far, considerable efforts such as reprecipitation and coassembly have been devoted to improve their stability in aqueous solution to output enhanced ECL signals.…”

Identifying 5-Hydroxymethylcytosine without Sequence Specificity Using MOF-Derived MnOxSy Nanoflowers for Boosting Electrochemiluminescence

“…Apparently, the MnO x S y NFs had amazing promoting performance toward the S 2 O 8 2– solution, making the ECL intensity of MnO x S y NFs/GCE (curve b in Figure D) 5.2 times stronger than that of bare GCE in the S 2 O 8 2– solution (curve a in Figure D). It could be attributed to the rich defect and hierarchical structures of MnO x S y NFs, which not only fully exposed active sites to adsorb and activate abundant reactants in a confined solution microenvironment, but also changed charge distribution and produced much more highly active catalytic sites to make the electrochemical reaction easier by sulfur doping. − …”

A Precise Microreactor for Ultralong Visible Chemiluminescence

“…18−21 They are also a talented platform for the CL process because the three key elements of CL (catalytic center: metal cluster; chromophore: organic ligand; controllable diffusion path: open and divisible channel) can be precisely integrated into a framework, which can be considered as an atomically precise microreactor for short energy transfer path, weaken relaxation of F, and controllable raw material diffusion rate (Scheme 1b). 22,23 Recently, some attempts at MOFs have been performed in CL systems. For example, Al Lawati et al 24 hemin-bridged MOF.…”