Metal–organic frameworks (MOFs) as effectual diagnostic and therapeutic tools for cancer

Abstract

Metal-organic frameworks (MOFs) are a class of multifunctional organometallic compounds that include metal ions combined with assorted organic linkers. Recently, these compounds have received widespread attention in medicine, due to...

Prospects, advances and biological applications of MOF-based platform for the treatment of lung cancer

“…TME is weakly acidic, and the difference in pH between cancer and normal cells allows targeted drug delivery by MOFs to the tumour region, resulting in a highly selective and safe method of drug delivery. 57 To date, pH-stimulated responsive drug release has been the best strategy for MOF-aided drug delivery.…”

Dose-Dependent Effect on Plant Growth of Exposure to Metal–Organic Framework MIL-101(Cr)

“…1−4 At present, MOFs have been widely applied in the fields of absorption, 5,6 separation, 7 sensors, 8,9 catalysis, 10 drug delivery, 11,12 and therapy. 13,14 Recently, MOFs have also shown great potential in agricultural development. 15,16 For example, MOFs can be applied to environmental remediation (removal of agrochemicals by adsorption or catalytic degradation), 17,18 environmental pollutant monitoring, 19 and plant drug delivery.…”

“…Metal–organic frameworks (MOFs) are porous materials composed of central metal ions or metal ion clusters and organic ligands. They have attracted great attention in recent decades for their exceptional properties, such as high surface areas, tunable porosity, and functional surfaces. − At present, MOFs have been widely applied in the fields of absorption, , separation, sensors, , catalysis, drug delivery, , and therapy. , Recently, MOFs have also shown great potential in agricultural development. , For example, MOFs can be applied to environmental remediation (removal of agrochemicals by adsorption or catalytic degradation), , environmental pollutant monitoring, and plant drug delivery . With the widespread application of MOFs, there is a pressing need to evaluate their environmental impacts.…”

Investigation on the Drug Release Efficacy of the Ibuprofen-Loaded ZIF-8/Fe3O4 NPs Nanocarrier

“…Therefore, to achieve better therapeutic action, the drug materials are required to bind with some carrier materials for the targeted drug delivery process . Two types of carriers generally work in the drug delivery system: one is the organic carrier, which includes polymer materials, micelles, liposomes, and protein nanoparticles, and the other includes porous materials such as zeolites, mesoporous silica, etc. − The porous materials are advantageous over other organic carriers due to their well-defined porosity and flexibility, which help in greater loading of drug molecules as well as their controlled release. , Despite various types of mesoporous materials, metal organic frameworks (also called supramolecular solids) are extensively used as drug carriers, as they possess a regular porosity, a large pore volume, flexible pore sizes with high thermal and chemical stability, and organic functionality. ,, They are constructed by metal atoms or metal clusters, called secondary building units (SBUs), connected with multidentate organic ligands with coordinate bonds . Structurally, metal organic frameworks contain hydrophilic and hydrophobic units, which help to tune their pore sizes and also help the guest molecules to interact with them.…”

“… 7 , 8 Despite various types of mesoporous materials, metal organic frameworks (also called supramolecular solids) are extensively used as drug carriers, as they possess a regular porosity, a large pore volume, flexible pore sizes with high thermal and chemical stability, and organic functionality. 1 , 9 , 10 They are constructed by metal atoms or metal clusters, called secondary building units (SBUs), connected with multidentate organic ligands with coordinate bonds. 11 Structurally, metal organic frameworks contain hydrophilic and hydrophobic units, which help to tune their pore sizes and also help the guest molecules to interact with them.…”