Metal–organic frameworks (MOFs) based electrochemical biosensors for early cancer diagnosis in vitro

Zhang, Shuai; Rong, Feilong; Guo, Chuanpan; Duan, Fenghe; He, Linghao; Wang, Minghua; Zhang, Zhihong; Kang, Mengmeng; Du, Miao

doi:10.1016/j.ccr.2021.213948

Cited by 163 publications

(56 citation statements)

References 264 publications

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“…Metal-organic frameworks (MOFs) are porous adjustable crystalline polymers of three-dimensional networks of organic linkers and metal clusters. Their unique micro-or mesoporous structure results in low density, high porosity, specific surface area, and structural diversity making them attractive candidates for sensing gas, drug delivery, analysis, sensing, and energy storage (Wang et al, 2020;Zhang et al, 2021;Zhu et al, 2022). Processing and handling of MOFs are of great importance due to their crystalline nature and powder structure (Denny et al, 2016;Song et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Taguchi-Assisted Optimization Technique and Density Functional Theory for Green Synthesis of a Novel Cu-MOF Derived From Caffeic Acid and Its Anticancerious Activities

et al. 2021

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In this paper, we have reported an innovative greener method for developing copper-metal organic frameworks (Cu-MOFs) using caffeic acid (CA) as a linker extracted from Satureja hortensis using ultrasonic bath. The density functional theory is used to discuss the Cu-MOF-binding reaction mechanism. In order to achieve a discrepancy between the energy levels of the interactive precursor orbitals, the molecules have been optimized using the B3LYP/6–31G method. The Taguchi method was used to optimize the key parameters for the synthesis of Cu-MOF. FT-IR, XRD, nitrogen adsorption, and SEM analyses are used to characterize it. The adsorption/desorption and SEM analyses suggested that Cu-MOF has a larger surface area of 284.94 m2/g with high porosity. Cu-MOF has shown anticancer activities against the human breast cancer (MDA-MB-468) cell lines, and it could be a potent candidate for clinical applications.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Taguchi-Assisted Optimization Technique and Density Functional Theory for Green Synthesis of a Novel Cu-MOF Derived From Caffeic Acid and Its Anticancerious Activities

et al. 2021

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“…The anticancer properties of samples were significant compared to previous samples. It can be related to selecting the novel nanostructures and also optimization the procedure ( Ji et al, 2020 ; Sun et al, 2021 ; Zhang et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment

et al. 2021

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In this study, novel nanostructures of aluminum base metal-organic framework (Al-MOF) samples were synthesized using a sustainable, non-toxic, and cost-effective green synthesis route. Satureja hortensis extract was used as an effective source of linker for the development of the Al-MOF structures. The Fourier-transformed infrared (FTIR) spectrum confirmed the presence of characterization bonds related to the Al-MOF nanostructures synthesized by the green synthesis route. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses revealed that the sample synthesized by Na2-CA was composed of multilayers, although it was agglomerated, but it had dispersed and occurred in spherical particles, indicating active organic matter. N2 adsorption/desorption isotherms demonstrated the significant porosity of the Al-MOF samples that facilitate the high potential of these nanostructures in medical applications. The anticancer treatment of Al-MOF samples was performed with different concentrations using the MTT standard method with untreated cancer cells for 24 and 48 h periods. The results exhibited the significant anticancer properties of Al-MOF samples developed in this study when compared with other MOF samples. Thus, the development of a novel Al-MOF and its application as a natural linker can influence the anticancer treatment of the samples. According to the results, the products developed in this study can be used in more applications such as biosensors, catalysts, and novel adsorbents.

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“…4 Their applications have been explored in various fields, including gas adsorption or separation, electrocatalysis, photocatalysis, energy storage, ion batteries, biosensors, and controlled delivery. 5–8 Further, MOFs/COFs have unique features of tunable pore size and periodic pores, which allow the incorporation of heteroatoms/metal coordinating moieties in a periodic way. However, some challenges still exist including their synthesis and functionalization, development of new nanostructures, and application in industry.…”

Section: Introductionmentioning

confidence: 99%

Heterostructured hybrids of metal–organic frameworks (MOFs) and covalent–organic frameworks (COFs)

et al. 2022

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Metal–organic frameworks (MOFs) based electrochemical biosensors for early cancer diagnosis in vitro

Cited by 163 publications

References 264 publications

RETRACTED: Taguchi-Assisted Optimization Technique and Density Functional Theory for Green Synthesis of a Novel Cu-MOF Derived From Caffeic Acid and Its Anticancerious Activities

RETRACTED: Taguchi-Assisted Optimization Technique and Density Functional Theory for Green Synthesis of a Novel Cu-MOF Derived From Caffeic Acid and Its Anticancerious Activities

Synthesis of Al-Based Metal-Organic Framework in Water With Caffeic Acid Ligand and NaOH as Linker Sources With Highly Efficient Anticancer Treatment

Heterostructured hybrids of metal–organic frameworks (MOFs) and covalent–organic frameworks (COFs)

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