Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery

Saeb, Mohammad Reza; Rabiee, Navid; Mozafari, Masoud; Mostafavi, Ebrahim

doi:10.3390/ma14133652

Cited by 64 publications

(38 citation statements)

References 51 publications

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“…Imaging and photofunctional technologies are rapidly developing to provide scientists with a visual tool for cancer diagnosis. Biological markers, or briefly biomarkers, function as an index to quantitatively express the state of the biological microenvironments for the sake of detection and diagnostic purposes [ 7 , 8 ]. Medical therapeutic approaches benefiting from biomarkers work on the basis of blood, urine, or soft tissues.…”

Section: Mofs In Detecting Cancer Biomarkersmentioning

confidence: 99%

Metal–Organic Frameworks (MOFs) for Cancer Therapy

et al. 2021

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MOFs exhibit inherent extraordinary features for diverse applications ranging from catalysis, storage, and optics to chemosensory and biomedical science and technology. Several procedures including solvothermal, hydrothermal, mechanochemical, electrochemical, and ultrasound techniques have been used to synthesize MOFs with tailored features. A continued attempt has also been directed towards functionalizing MOFs via “post-synthetic modification” mainly by changing linkers (by altering the type, length, functionality, and charge of the linkers) or node components within the MOF framework. Additionally, efforts are aimed towards manipulating the size and morphology of crystallite domains in the MOFs, which are aimed at enlarging their applications window. Today’s knowledge of artificial intelligence and machine learning has opened new pathways to elaborate multiple nanoporous complex MOFs and nano-MOFs (NMOFs) for advanced theranostic, clinical, imaging, and diagnostic purposes. Successful accumulation of a photosensitizer in cancerous cells was a significant step in cancer therapy. The application of MOFs as advanced materials and systems for cancer therapy is the main scope beyond this perspective. Some challenging aspects and promising features in MOF-based cancer diagnosis and cancer therapy have also been discussed.

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Section: Mofs In Detecting Cancer Biomarkersmentioning

confidence: 99%

Metal–Organic Frameworks (MOFs) for Cancer Therapy

et al. 2021

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“…Zn-based MOFs have added beneficial aspects in drug delivery as efficient medicinal carriers; they also have other applications. Here, we will summarize the applications of MOFs in various disciplines [ 107 ].…”

Section: Applications Of Zn-based Mofs For Gases Adsorption Imaging and Sensorsmentioning

confidence: 99%

Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

Ali

Meng

2021

Molecules

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The design and structural frameworks for targeted drug delivery of medicinal compounds and improved cell imaging have been developed with several advantages. However, metal-organic frameworks (MOFs) are supplemented tremendously for medical uses with efficient efficacy. These MOFs are considered as an absolutely new class of porous materials, extensively used in drug delivery systems, cell imaging, and detecting the analytes, especially for cancer biomarkers, due to their excellent biocompatibility, easy functionalization, high storage capacity, and excellent biodegradability. While Zn-metal centers in MOFs have been found by enhanced efficient detection and improved drug delivery, these Zn-based MOFs have appeared to be safe as elucidated by different cytotoxicity assays for targeted drug delivery. On the other hand, the MOF-based heterogeneous catalyst is durable and can regenerate multiple times without losing activity. Therefore, as functional carriers for drug delivery, cell imaging, and chemosensory, MOFs’ chemical composition and flexible porous structure allowed engineering to improve their medical formulation and functionality. This review summarizes the methodology for fabricating ultrasensitive and selective Zn-MOF-based sensors, as well as their application in early cancer diagnosis and therapy. This review also offers a systematic approach to understanding the development of MOFs as efficient drug carriers and provides new insights on their applications and limitations in utility with possible solutions.

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“…In the meantime, such standards can also help research advance more expeditiously and efficiently. Our aim in this study is to focus on establishing a physicochemical standard for smart cargo delivery in inorganic systems [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Also, interdisciplinary researchers could be considered a tool for rapid movements and advancements to the early diagnosis and detection of different kinds of diseases, pathogens, and biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Porphyrin Molecules Decorated on Metal-Organic Frameworks for Multi-Functional Biomedical Applications

Rabiee

Sojdeh

et al. 2021

Biomolecules

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Metal–organic frameworks (MOFs) have been widely used as porous nanomaterials for different applications ranging from industrial to biomedicals. An unpredictable one-pot method is introduced to synthesize NH2-MIL-53 assisted by high-gravity in a greener media for the first time. Then, porphyrins were deployed to adorn the surface of MOF to increase the sensitivity of the prepared nanocomposite to the genetic materials and in-situ cellular protein structures. The hydrogen bond formation between genetic domains and the porphyrin’ nitrogen as well as the surface hydroxyl groups is equally probable and could be considered a milestone in chemical physics and physical chemistry for biomedical applications. In this context, the role of incorporating different forms of porphyrins, their relationship with the final surface morphology, and their drug/gene loading efficiency were investigated to provide a predictable pattern in regard to the previous works. The conceptual phenomenon was optimized to increase the interactions between the biomolecules and the substrate by reaching the limit of detection to 10 pM for the Anti-cas9 protein, 20 pM for the single-stranded DNA (ssDNA), below 10 pM for the single guide RNA (sgRNA) and also around 10 nM for recombinant SARS-CoV-2 spike antigen. Also, the MTT assay showed acceptable relative cell viability of more than 85% in most cases, even by increasing the dose of the prepared nanostructures.

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Metal-Organic Frameworks (MOFs)-Based Nanomaterials for Drug Delivery

Cited by 64 publications

References 51 publications

Metal–Organic Frameworks (MOFs) for Cancer Therapy

Metal–Organic Frameworks (MOFs) for Cancer Therapy

Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

Porphyrin Molecules Decorated on Metal-Organic Frameworks for Multi-Functional Biomedical Applications

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