Metal-organic frameworks/polydopamine coating endows polyetheretherketone with disinfection and osteogenicity

Chen, Yong; Yang, Qizhang; Ma, Dandan; Peng, Liming; Mao, Yurong; Zhou, Xiong; Deng, Yi; Yang, Weizhong

doi:10.1080/00914037.2021.1909585

Cited by 8 publications

(6 citation statements)

References 53 publications

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“…Moreover, illuminationsensitive and pH-sensitive systems target antibacterial and osteogenic abilities at the same time. The systems with PDA-wrapped zeolitic imidazolate framework-8, (CuFe 2 O 4 )/GO and black tantalic oxide resulted in hypothermia and ROS generation at 808 nm NIR illumination [57, 120,135]. The pH-responsive system included copper citrate.…”

Section: Coating With An Antibacterial Materialsmentioning

confidence: 99%

“…Phototermal therapy is another approach to regulating antibacterial properties. A sudden increase in the temperature at the infection site can be provided using the photothermal ability of coated materials instead of the burst release of an antibacterial agent [120,135].…”

Section: Conclusion and Prospectmentioning

confidence: 99%

“…In most of the studies using the coating process to increase the antibacterial response of PEEK, osteogenic properties and biocompatibility were investigated [52,55,56,59,68,80,119,128,133,135]. The coating of ZnO/Ag nanoparticles on PEEK showed elongated and overlapped lamellipodia in MG-63 cells, which was the indicator of healthy cells.…”

Section: Coating With An Antibacterial Materialsmentioning

confidence: 99%

“…Smart biomaterials are another area that emerged in the field [175]. Since there were some examples of photo-responsive [57, 120,135] and pH-responsive [137,138] systems for PEEK, other techniques such as enzyme-responsive, electrical stimuli-responsive, vibration-responsive and magnetic-responsive systems can be developped for PEEK implants to provide a solution-oriented approach and better control over drug release, biocompatibility and antibacterial efficiency [175]. Salivary and bacterial enzymes can be used as a stimulus for releasing antibacterial agents.…”

Section: Conclusion and Prospectmentioning

confidence: 99%

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Methods to improve antibacterial properties of PEEK: A review

Uysal,

Tezcaner,

Evis

2024

Biomed. Mater.

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As a thermoplastic and bioinert polymer, polyether ether ketone (PEEK) serves as spine implants, femoral stems, cranial implants, and joint arthroplasty implants due to its mechanical properties resembling the cortical bone, chemical stability, and radiolucency. Although there are standards and antibiotic treatments for infection control during and after surgery, the infection risk is lowered but can not be eliminated. The antibacterial properties of PEEK implants should be improved to provide better infection control. This review includes the strategies for enhancing the antibacterial properties of PEEK in four categories: immobilization of functional materials and functional groups, forming nanocomposites, changing surface topography, and coating with antibacterial material. The measuring methods of antibacterial properties of the current studies of PEEK are explained in detail under quantitative, qualitative, and in vivo methods. The mechanisms of bacterial inhibition by reactive oxygen species (ROS) generation, contact killing, trap killing, and limited bacterial adhesion on hydrophobic surfaces are explained with corresponding antibacterial compounds or techniques. The prospective analysis of the current studies is done, and dual systems combining osteogenic and antibacterial agents immobilized on the surface of PEEK are found the promising solution for a better implant design.

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Section: Coating With An Antibacterial Materialsmentioning

confidence: 99%

Section: Conclusion and Prospectmentioning

confidence: 99%

Section: Coating With An Antibacterial Materialsmentioning

confidence: 99%

Section: Conclusion and Prospectmentioning

confidence: 99%

See 2 more Smart Citations

Methods to improve antibacterial properties of PEEK: A review

Uysal,

Tezcaner,

Evis

2024

Biomed. Mater.

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“…It has been shown to have superior osteogenic properties and antibacterial activity 36,37 and can achieve photothermal therapeutic effects under infrared light. 38 Chen et al 39 developed a polydopamine(PDA)-wrapped ZIF-8 coating on sulfonated PEEK (SPEEK). The coating allows for controlled release of Zn 2+ and exhibits a strong photothermal capacity under near-infrared (NIR) irradiation.…”

Section: Surface Modification Substance Coatingsmentioning

confidence: 99%

Multifaceted Materials for Enhanced Osteogenesis and Antimicrobial Properties on Bioplastic Polyetheretherketone Surfaces: A Review

Bai,

Zhao,

Cui

et al. 2024

ACS Omega

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Implant-associated infections and the increasing number of bone implants loosening and falling off after implantation have become urgent global challenges, hence the need for intelligent alternative solutions to combat implant loosening and falling off. The application of polyetheretherketone (PEEK) in biomedical and medical therapy has aroused great interest, especially because its elastic modulus close to bone provides an effective alternative to titanium implants, thereby preventing the possibility of bone implants loosening and falling off due to the mismatch of elastic modulus. In this Review, we provide a comprehensive overview of recent advances in surface modifications to prevent bone binding deficiency and bacterial infection after implantation of bone implants, starting with inorganics for surface modification, followed by organics that can effectively promote bone integration and antimicrobial action. In addition, surface modifications derived from cells and related products of biological activity have been proposed, and there is increasing evidence of clinical potential. Finally, the advantages and future challenges of surface strategies against medical associated poor osseointegration and infection are discussed, with promising prospects for developing novel osseointegration and antimicrobial PEEK materials.

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Metal-organic framework-based advanced therapeutic tools for antimicrobial applications

Chen,

Xing,

et al. 2024

Acta Biomaterialia

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Metal-organic frameworks/polydopamine coating endows polyetheretherketone with disinfection and osteogenicity

Cited by 8 publications

References 53 publications

Methods to improve antibacterial properties of PEEK: A review

Methods to improve antibacterial properties of PEEK: A review

Multifaceted Materials for Enhanced Osteogenesis and Antimicrobial Properties on Bioplastic Polyetheretherketone Surfaces: A Review

Metal-organic framework-based advanced therapeutic tools for antimicrobial applications

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