Metal–organic frameworks towards bio-medical applications

Ma, Xin; Lepoitevin, Mathilde; Serre, Christian

doi:10.1039/d1qm00784j

Cited by 58 publications

(39 citation statements)

References 154 publications

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“…For example, the use of inorganic nanocrystals as nanocarriers for drug delivery presents various interesting specificities. Inorganic nanocarriers such as mesoporous silica [68], metal-organic framework [69,70] nanocrystals such as calcium phosphate, gold, iron oxide and quantum dots, have been studied for drug delivery [71,72]. They may have better stability against biodegradation than organic nanocarriers and may enable a more favorable biodistribution for drugs.…”

Section: Inorganic Nanocrystals As Therapeutic Enhancersmentioning

confidence: 99%

Designing the Surface Chemistry of Inorganic Nanocrystals for Cancer Imaging and Therapy

Delille

Lequeux

et al. 2022

Cancers

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Inorganic nanocrystals, such as gold, iron oxide and semiconductor quantum dots, offer promising prospects for cancer diagnostics, imaging and therapy, due to their specific plasmonic, magnetic or fluorescent properties. The organic coating, or surface ligands, of these nanoparticles ensures their colloidal stability in complex biological fluids and enables their functionalization with targeting functions. It also controls the interactions of the nanoparticle with biomolecules in their environment. It therefore plays a crucial role in determining nanoparticle biodistribution and, ultimately, the imaging or therapeutic efficiency. This review summarizes the various strategies used to develop optimal surface chemistries for the in vivo preclinical and clinical application of inorganic nanocrystals. It discusses the current understanding of the influence of the nanoparticle surface chemistry on its colloidal stability, interaction with proteins, biodistribution and tumor uptake, and the requirements to develop an optimal surface chemistry.

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Section: Inorganic Nanocrystals As Therapeutic Enhancersmentioning

confidence: 99%

Designing the Surface Chemistry of Inorganic Nanocrystals for Cancer Imaging and Therapy

Delille

Lequeux

et al. 2022

Cancers

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“…16,17 Combined with recent advances in nanoparticle synthesis, MOFs have shown great promise in a number of applications ranging from catalysis to biomedicine. [18][19][20] First reports of nanoMOFs as radioenhancers were published in 2018 when the Lin group used hafnium-based SBUs to synthesize high-Z nanoMOFs. By comparing two Hf-MOFs that differ in their SBU, they not only showed that the SBU choice influences the X-ray absorption efficiency but also confirmed that a larger surface area leads to increased ROS production.…”

Section: Introductionmentioning

confidence: 99%

Cellular fate and performance of group IV metal organic framework radioenhancers

et al. 2022

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“…Porous organic materials, such as metal‐organic frameworks (MOFs), porous polymers, or porous carbonaceous materials are an emerging class of functional nanostructures with unusual properties, which found applications in storage, catalysis, electronic and proton conductivity, [153] as sensors [154] or for molecular separation, [155] as well as in biomedical applications [156] . Structural parameters of the pores are adaptable in many ways by variation of pore volume, topology, surface area, resulting from the modifications of their chemical composition [157] .…”

Section: Photochromic Materials Triggered With Visible Lightmentioning

confidence: 99%

Smart Photochromic Materials Triggered with Visible Light

Leistner

Pianowski

2022

Eur J Org Chem

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Molecular photoswitches reversibly convert the energy of light into a variety of structural changes at the molecular level. They can be integrated into smart materials with broad range of applicability. While most photochromic systems require UV light for activation, application of photoswitches operational entirely within the visible or NIR range of light brings considerable benefits, such as biocompatibility, better light penetration through the material, propelling with sunlight, or a possibility to design dual systems that are mutually activated with UV or visible light frequencies for two distinct functions. In this Review, we discuss the most relevant classes of molecular photoswitches, and demonstrate a selection of photochromic polymers, gels, porous materials, surfaces, energy-storing materials and other systems triggered with visible light.The main challenge in design of visible-light-triggered systems, including molecular switches, [21] is the fact that nonradiative [a] A.

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Metal–organic frameworks towards bio-medical applications

Abstract: This mini review summarises the progress in the field of MOFs and their use in biomedical applications, from their early discovery and conception, to more recent achievements including promising in...

Cited by 58 publications

References 154 publications

Designing the Surface Chemistry of Inorganic Nanocrystals for Cancer Imaging and Therapy

Designing the Surface Chemistry of Inorganic Nanocrystals for Cancer Imaging and Therapy

Cellular fate and performance of group IV metal organic framework radioenhancers

Smart Photochromic Materials Triggered with Visible Light

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