Metal oxide -based electrical/electrochemical sensors for health monitoring systems

Taheri, Mahtab; Deen, Imran A.; Packirisamy, Muthukumaran; Deen, M. Jamal

doi:10.1016/j.trac.2023.117509

Cited by 8 publications

(9 citation statements)

References 236 publications

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“…Chemical sensors such as MOX-type sensors (semiconductor metal oxide gas sensors) have demonstrated the clear advantages of the application of this technology in recent years, and have been used with considerable success in several sectors, ranging from food safety [ 20 ], quality control [ 21 ] and environmental monitoring to human health, particularly due to their high sensitivity, fast response and low costs. For these reasons, this work investigates the feasibility of integrating electrochemical sensors and virtual sensing in order to benefit from both approaches.…”

Section: Introductionmentioning

confidence: 99%

Data-Driven Virtual Sensing for Electrochemical Sensors

Sangiorgi,

Sberveglieri,

Carnevale

et al. 2024

Sensors

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In recent years, the application of machine learning for virtual sensing has revolutionized the monitoring and management of information. In particular, electrochemical sensors generate large amounts of data, allowing the application of complex machine learning/AI models able to (1) reproduce the measured data and (2) predict and manage faults in the measuring sensor. In this work, data-driven models based on an autoregressive model and an artificial neural network have been identified and used to (i) evaluate sensor redundancy and (ii) predict and manage faults in the context of electrochemical sensors for the measurement of ethanol. The approach shows encouraging results in terms of both performance and sensitivity analyses, allowing for the reconstruction of the values measured by two sensors in a series of six sensors with different dopant levels and to reproduce their values after a fault.

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Section: Introductionmentioning

confidence: 99%

Data-Driven Virtual Sensing for Electrochemical Sensors

Sangiorgi,

Sberveglieri,

Carnevale

et al. 2024

Sensors

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“…However, they may be susceptible to aggregation and complex synthesis [ 42 ]. In microfabrication, metal oxides offer stability and compatibility [ 43 ], but they are not selective and are prone to interference [ 44 ]. The mechanical strength and conductivity of carbonaceous materials are high, but they are also susceptible to nonspecific binding and surface fouling [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

Kuntoji,

Kousar,

Gaddimath

et al. 2024

Biosensors

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Biosensors function as sophisticated devices, converting biochemical reactions into electrical signals. Contemporary emphasis on developing biosensor devices with refined sensitivity and selectivity is critical due to their extensive functional capabilities. However, a significant challenge lies in the binding affinity of biosensors to biomolecules, requiring adept conversion and amplification of interactions into various signal modalities like electrical, optical, gravimetric, and electrochemical outputs. Overcoming challenges associated with sensitivity, detection limits, response time, reproducibility, and stability is essential for efficient biosensor creation. The central aspect of the fabrication of any biosensor is focused towards forming an effective interface between the analyte electrode which significantly influences the overall biosensor quality. Polymers and macromolecular systems are favored for their distinct properties and versatile applications. Enhancing the properties and conductivity of these systems can be achieved through incorporating nanoparticles or carbonaceous moieties. Hybrid composite materials, possessing a unique combination of attributes like advanced sensitivity, selectivity, thermal stability, mechanical flexibility, biocompatibility, and tunable electrical properties, emerge as promising candidates for biosensor applications. In addition, this approach enhances the electrochemical response, signal amplification, and stability of fabricated biosensors, contributing to their effectiveness. This review predominantly explores recent advancements in utilizing macrocyclic and macromolecular conjugated systems, such as phthalocyanines, porphyrins, polymers, etc. and their hybrids, with a specific focus on signal amplification in biosensors. It comprehensively covers synthetic strategies, properties, working mechanisms, and the potential of these systems for detecting biomolecules like glucose, hydrogen peroxide, uric acid, ascorbic acid, dopamine, cholesterol, amino acids, and cancer cells. Furthermore, this review delves into the progress made, elucidating the mechanisms responsible for signal amplification. The Conclusion addresses the challenges and future directions of macromolecule-based hybrids in biosensor applications, providing a concise overview of this evolving field. The narrative emphasizes the importance of biosensor technology advancement, illustrating the role of smart design and material enhancement in improving performance across various domains.

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“…Among nanomaterials, metal oxide nanostructures are known as one of the effective candidates for electrode modifications owing to their excellent electrocatalytic activities, low cost, nontoxicity, and chemical stability. 8,9 These metal oxides are also very attractive because of the ease of fabrication and tailoring of their properties through simple material synthesis or design process. 10 Moreover, metal oxide nanostructures could be easily immobilized on working electrode surface by kinds of methods including physical adsorption, chemical covalent bonding, electrodeposition, and so on.…”

mentioning

confidence: 99%

“…10 Moreover, metal oxide nanostructures could be easily immobilized on working electrode surface by kinds of methods including physical adsorption, chemical covalent bonding, electrodeposition, and so on. 8,9 The electrocatalytic activities of metal oxide could decrease overpotential of some redox reactions at the electrode surface and improve the electron transfer ability across the interface of electrode and electrolyte. 9 However, due to the complex reaction process, it is still needed to clarify the key physical or chemical factors contributing most to the difference in the sensing performance for a given analyte.…”

mentioning

confidence: 99%

“…8,9 The electrocatalytic activities of metal oxide could decrease overpotential of some redox reactions at the electrode surface and improve the electron transfer ability across the interface of electrode and electrolyte. 9 However, due to the complex reaction process, it is still needed to clarify the key physical or chemical factors contributing most to the difference in the sensing performance for a given analyte. Moreover, the physical insights behind the phenomenological phase-dependent electrochemistry for metal oxide nanostructures is still unclear.…”

mentioning

confidence: 99%

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A Physical Insight of Phase-Dependent Electron Transfer Kinetic Behaviors and Electrocatalytic Activity of an Iron Oxide-Based Sensing Nanoplatform Towards Chloramphenicol

Ngo,

Phung,

Nguyen

et al. 2024

J. Electrochem. Soc.

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Insight into the phase-dependent electron transfer kinetics and electrocatalytic activity of metal oxide nanostructures is important in the rational design of functional nanostructures for realizing high-performance electrochemical sensors. This study focuses on elucidating the effect of the crystalline phase on the electron transfer kinetics and electrocatalytic activity of iron(III) oxide. The α-FeOOH, γ-Fe2O3, and α-Fe2O3 nanorods were designed by using a simple chemical method and calcining process. The phase-dependent difference in the electron transfer kinetics and electrocatalytic activity toward the sensitive response of chloramphenicol (CAP) is observed by the transformation from α-FeOOH to γ-Fe2O3, and from α-FeOOH to α-Fe2O3 nanorods. We found that the oxygen vacancies formed in phase transformation from α-FeOOH to α-Fe2O3 is a key factor in promoting the electrochemical reduction of chloramphenicol. The α-Fe2O3 nanorods-based electrochemical sensors showed a linear response in the CAP concentration range from 0.1 to 75 µM with a limit of detection of 60 nM and an electrochemical sensitivity of 2.86 µA µM-1cm-2. This work further provides valuable physical insight into the phase-dependent electron transfer kinetics and electrocatalytic activity of metal oxide nanostructures for the rational design of sensing interface.

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Metal oxide -based electrical/electrochemical sensors for health monitoring systems

Cited by 8 publications

References 236 publications

Data-Driven Virtual Sensing for Electrochemical Sensors

Data-Driven Virtual Sensing for Electrochemical Sensors

Macromolecule–Nanoparticle-Based Hybrid Materials for Biosensor Applications

A Physical Insight of Phase-Dependent Electron Transfer Kinetic Behaviors and Electrocatalytic Activity of an Iron Oxide-Based Sensing Nanoplatform Towards Chloramphenicol

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