Metal Oxide Nanoparticles as Biomedical Materials

Nikolova, Maria P.; Chavali, Murthy

doi:10.3390/biomimetics5020027

Cited by 338 publications

(167 citation statements)

References 279 publications

(310 reference statements)

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“…[ 23 , 24 , 25 ], drug delivery [ 26 , 27 , 28 ], viral sensing [ 29 ] or dental materials applications [ 30 ]. MPs are a category of nanoparticles of special interest that covers numerous such applications, including diagnosis, biosensing, tissue and immune therapy, regenerative medicine and dentistry [ 31 , 32 , 33 , 34 ]. MPs used in biomedical applications are manufactured from certain materials: metals (Fe or Co), different alloys (such as Au/Fe), oxides (magnetite or maghemite), as well as different types of ferrites.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the first aim above, magnetic nanoparticles (MPs) manufactured in the laboratory are inserted in the adhesive, which is prepared with different procedures to optimize the adhesive distribution in the interface. Nanoparticles [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ], including MPs are largely used in medicine [ 31 , 32 , 33 , 34 , 35 ]. To our knowledge, we proposed using MPs for the first time in a series of preliminary studies [ 36 , 37 , 38 ] with the scope of obtaining a tighter connection between the composite material and the dental surface [ 39 , 40 ], compared with a conventional treatment.…”

Section: Introductionmentioning

confidence: 99%

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Dental Adhesive Interfaces Reinforced with Magnetic Nanoparticles: Evaluation and Modeling with Micro-CT versus Optical Microscopy

et al. 2020

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Dental adhesives are used in a wide range of applications, including to place direct composite restorations in frontal or posterior teeth. One of the most frequent causes for the failure of composite resin restorations is microleakages. The first aim of this work is to introduce a new type of self-etched dental adhesive doped with magnetic nanoparticles (MPs) synthetized in the laboratory. The scope is to produce adhesives with a minimized width/thickness to decrease the risk of microleakages. The second aim is to assess the width/thickness of the adhesive layer in all the characteristic areas of the teeth using both the less precise but most common optical microscopy and the more accurate and volumetric micro-Computed Tomography (CT) investigations. Twenty extracted teeth have been divided into four groups: Group 1 includes ‘blank’ samples with adhesives that are not doped with MPs; Group 2 includes samples with adhesives doped with MPs; Groups 3 and 4 include samples with adhesives doped with MPs that are subjected to an active magnetic field for 5 and 10 min, respectively. Microscopy investigations followed by micro-CT and EDAX are performed on the adhesive. While a rather good agreement is obtained between the microscopy and micro-CT results, the capability of the latter to offer a full volumetric reconstruction of the layer is exploited to analyze the adhesion of the four considered dental materials. Thus, from micro-CT results the graphs of the surface areas as functions of the adhesive layer width are modeled mathematically, as well as the volume of sealants, for each of the four groups. To our knowledge, it is the first time that such a methodology is used. Characteristic parameters are extracted and the ascertainment of the optimal parameter that should be utilized for such assessments is discussed. The study demonstrates the adhesion improvement produced for Groups 3 and 4, where MPs are used. It also concludes that the magnetic field should be applied to the adhesive material for the longest possible exposure time (with a trade-off with the clinical duration of the treatment).

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dental Adhesive Interfaces Reinforced with Magnetic Nanoparticles: Evaluation and Modeling with Micro-CT versus Optical Microscopy

et al. 2020

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“…Briefly, a high surface area to volume ratio, amenability to surface modification, small size (less than 10 nm), inert nature, biocompatibility and biosafety with easy clearance from tissue make these nanoparticles a suitable choice for antimicrobial therapy and drug delivery [ 13 , 14 , 15 ]. Other metallic nanoparticles made of copper, zinc, titanium, cerium and their respective oxides offer similar advantages [ 16 ]; however, their toxic effects in humans and the environment outweigh their advantages [ 17 , 18 ]. In addition, the literature showing antimicrobial effects of other metallic nanoparticles and possible mechanistic details behind their action is very limited.…”

Section: Gold and Silver Nanoparticles As Antimicrobial Agentsmentioning

confidence: 99%

Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance

Joshi

Singh

Mijaković

2020

IJMS

182

113

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Many bacteria have the capability to form a three-dimensional, strongly adherent network called ‘biofilm’. Biofilms provide adherence, resourcing nutrients and offer protection to bacterial cells. They are involved in pathogenesis, disease progression and resistance to almost all classical antibiotics. The need for new antimicrobial therapies has led to exploring applications of gold and silver nanoparticles against bacterial biofilms. These nanoparticles and their respective ions exert antimicrobial action by damaging the biofilm structure, biofilm components and hampering bacterial metabolism via various mechanisms. While exerting the antimicrobial activity, these nanoparticles approach the biofilm, penetrate it, migrate internally and interact with key components of biofilm such as polysaccharides, proteins, nucleic acids and lipids via electrostatic, hydrophobic, hydrogen-bonding, Van der Waals and ionic interactions. Few bacterial biofilms also show resistance to these nanoparticles through similar interactions. The nature of these interactions and overall antimicrobial effect depend on the physicochemical properties of biofilm and nanoparticles. Hence, study of these interactions and participating molecular players is of prime importance, with which one can modulate properties of nanoparticles to get maximal antibacterial effects against a wide spectrum of bacterial pathogens. This article provides a comprehensive review of research specifically directed to understand the molecular interactions of gold and silver nanoparticles with various bacterial biofilms.

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“… Examples of various nanoscale filler morphologies used in polymer nanocomposites. Adapted from [ 37 ]. …”

Section: Figurementioning

confidence: 99%

Nanocomposites for Food Packaging Applications: An Overview

et al. 2020

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There is a strong drive in industry for packaging solutions that contribute to sustainable development by targeting a circular economy, which pivots around the recyclability of the packaging materials. The aim is to reduce traditional plastic consumption and achieve high recycling efficiency while maintaining the desired barrier and mechanical properties. In this domain, packaging materials in the form of polymer nanocomposites (PNCs) can offer the desired functionalities and can be a potential replacement for complex multilayered polymer structures. There has been an increasing interest in nanocomposites for food packaging applications, with a five-fold rise in the number of published articles during the period 2010–2019. The barrier, mechanical, and thermal properties of the polymers can be significantly improved by incorporating low concentrations of nanofillers. Furthermore, antimicrobial and antioxidant properties can be introduced, which are very relevant for food packaging applications. In this review, we will present an overview of the nanocomposite materials for food packaging applications. We will briefly discuss different nanofillers, methods to incorporate them in the polymer matrix, and surface treatments, with a special focus on the barrier, antimicrobial, and antioxidant properties. On the practical side migration issues, consumer acceptability, recyclability, and toxicity aspects will also be discussed.

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Metal Oxide Nanoparticles as Biomedical Materials

Cited by 338 publications

References 279 publications

Dental Adhesive Interfaces Reinforced with Magnetic Nanoparticles: Evaluation and Modeling with Micro-CT versus Optical Microscopy

Dental Adhesive Interfaces Reinforced with Magnetic Nanoparticles: Evaluation and Modeling with Micro-CT versus Optical Microscopy

Interactions of Gold and Silver Nanoparticles with Bacterial Biofilms: Molecular Interactions behind Inhibition and Resistance

Nanocomposites for Food Packaging Applications: An Overview

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