Metal Oxide/Polymer Hybrid Nanoparticles with Versatile Functionality Prepared by Controlled Surface Crystallization

Fischer, Viktor; Lieberwirth, Ingo; Jakob, G.; Landfester, Katharina; Muñoz‐Espí, Rafael

doi:10.1002/adfm.201201839

Cited by 63 publications

(52 citation statements)

References 67 publications

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“…XRD analysis: X-ray diffraction (XRD) of the dried powder samples was conducted on a Philips PW 1820 diffractometer with monochromatic Cu-K α radiation (λ¼ 1.5418 Å, 40 kV, 30 mA, 5 s, Δθ¼0.02) [18].…”

Section: Methodsmentioning

confidence: 99%

A new polyphosphate calcium material with morphogenetic activity

et al. 2015

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Section: Methodsmentioning

confidence: 99%

A new polyphosphate calcium material with morphogenetic activity

et al. 2015

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“…[67] EDX Analysis: The experiments were performed with an EDAX Genesis EDX System attached to a scanning electron microscope (Nova 600 Nanolab, FEI, Eindhoven; The Netherlands). [67] EDX Analysis: The experiments were performed with an EDAX Genesis EDX System attached to a scanning electron microscope (Nova 600 Nanolab, FEI, Eindhoven; The Netherlands).…”

Section: Methodsmentioning

confidence: 99%

In Situ Polyphosphate Nanoparticle Formation in Hybrid Poly(vinyl alcohol)/Karaya Gum Hydrogels: A Porous Scaffold Inducing Infiltration of Mesenchymal Stem Cells

et al. 2018

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The preparation and characterization of a porous hybrid cryogel based on the two organic polymers, poly(vinyl alcohol) (PVA) and karaya gum (KG), into which polyphosphate (polyP) nanoparticles have been incorporated, are described. The PVA/KG cryogel is prepared by intermolecular cross‐linking of PVA via freeze‐thawing and Ca2+‐mediated ionic gelation of KG to form stable salt bridges. The incorporation of polyP as amorphous nanoparticles with Ca2+ ions (Ca‐polyP‐NP) is achieved using an in situ approach. The polyP constituent does not significantly affect the viscoelastic properties of the PVA/KG cryogel that are comparable to natural soft tissue. The exposure of the Ca‐polyP‐NP within the cryogel to medium/serum allows the formation of a biologically active polyP coacervate/protein matrix that stimulates the growth of human mesenchymal stem cells in vitro and provides the cells a suitable matrix for infiltration superior to the polyP‐free cryogel. In vivo biocompatibility studies in rats reveal that already two to four weeks after implantation into muscle, the implant regions containing the polyP‐KG/PVA material become replaced by initial granulation tissue, whereas the controls are free of any cells. It is proposed that the polyP‐KG/PVA cryogel has the potential to become a promising implant material for soft tissue engineering/repair.

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“…[145] The presence of the phosphonate group in the surfmer also allowed crystallization of hydroxylapatite on the particle surface. [145] The presence of the phosphonate group in the surfmer also allowed crystallization of hydroxylapatite on the particle surface.…”

Section: Surfactants With a Templating Effectmentioning

confidence: 99%

Functional Colloidal Stabilization

Bijlard

Wald

Crespy

et al. 2016

Adv Materials Inter

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acids), and protective agents. The unifying concept and key property of colloidal stabilizers is to provide a significant repulsion between the individual dispersed particles, making the heterophase system kinetically stable, which is typically accomplished via electrostatic or steric stabilization.Functional colloid stabilization provides additional features in addition to simple repulsion via physisorbed molecules. In fact, it is surprising that the majority of artificial heterophase systems have overlooked the simple and efficient possibility of spatially resolved chemical modification. The utilization of surface-active functional stabilizers is a fast and flexible method to obtain colloidal particles with strongly improved interaction properties. This functionalization has proved extremely material-and time-efficient. Due to the self-assembling ability of the stabilizers, the functional groups allow for an exact positioning of chemical and physical interaction sites directly in the surface region of the colloidal particle.The purpose of this review is to highlight functional colloidal stabilization as defined above. Our main focus concentrates on reactive systems, especially heterophase polymerization in oil-in-water (o/w) and water-in-oil (w/o) emulsions; a waterin-oil emulsion is regarded as an inverse emulsion. We differentiate between various types of surfactants which can either adsorb or react to the dispersed material with one segment, while the second part of the amphiphile stabilizes the dispersion. The stability of emulsions can be obtained by either low or high mole cular weight surfactants. Additionally, we distinguish between surfactants from so-called protective colloids of higher mole cular weight without significant self-aggregation properties. Throughout this review, the literature on functional colloidal stabilizers was revised and classified according to molecular weight, preparation technique, chemical structure, and stimuli-responsive behavior. Certain aspects such as inorganic/organic hybrids, or bioconjugates with sequence-defined structures such as peptides and nucleotides, are not in the scope of the present review and will only be briefly described when relevant.The review is structured as follows: we start with a brief summary of conventional low molecular weight (Section 2.1) and polymeric surfactants (Section 2.2) which typically lack of additional function besides the colloid stabilization. Only some of these also industrially used surfactants carry, for example, olefins or hydroxyl-groups embedded in their chemical structure, but do not have additional handles to the colloids. After this Surfactants can stabilize colloids in dispersion; however, also additional chemical or physical functions can be added by the surfactant chemistry to the colloid. This review covers functional colloid stabilization whereby supplementary features in addition to simple repulsion via physisorbed mole cules are described. The utilization of surface-active functional stabilizers as a fast and flexibl...

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Metal Oxide/Polymer Hybrid Nanoparticles with Versatile Functionality Prepared by Controlled Surface Crystallization

Cited by 63 publications

References 67 publications

A new polyphosphate calcium material with morphogenetic activity

A new polyphosphate calcium material with morphogenetic activity

In Situ Polyphosphate Nanoparticle Formation in Hybrid Poly(vinyl alcohol)/Karaya Gum Hydrogels: A Porous Scaffold Inducing Infiltration of Mesenchymal Stem Cells

Functional Colloidal Stabilization

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