Metal Particulate Matter Components Affect Gene Expression and Beat Frequency of Neonatal Rat Ventricular Myocytes

Graff, Donald W.; Cascio, Wayne E.; Brackhan, Joseph A.; Devlin, Robert B.

doi:10.1289/txg.6865

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Zinc, an essential transition divalent cation, is involved in maintaining and regulating cellular and subcellular functions of virtually all cells. Four major roles of Zn 21 have been reported: 1), it binds tightly to metalloenzymes and serves as a cofactor in gene expression and enzymatic reactions (3); 2), it is abundant in the brain, where it is localized in the presynaptic terminals, is coreleased with glutamate (4,5), and regulates neuronal excitability and synaptic plasticity (6,7); 3), it is involved in many pathological neuromodulatory events, and the accumulation of Zn 21 during and after transient global ischemia (8,9) can also affect cardiac functions (10,11); and 4), it regulates conductivity of VDCCs (12)(13)(14) and affects Ca 21 signaling.…”

Section: Introductionmentioning

confidence: 99%

Zn2+ Sensitivity of High- and Low-Voltage Activated Calcium Channels

Sun

Hui

Lee

et al. 2007

Biophysical Journal

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The essential cation zinc (Zn2+) blocks voltage-dependent calcium channels in several cell types, which exhibit different sensitivities to Zn2+. The specificity of the Zn2+ effect on voltage-dependent calcium channel subtypes has not been systematically investigated. In this study, we used a transient protein expression system to determine the Zn2+ effect on low- and high-voltage activated channels. We found that in Ba2+, the IC50 value of Zn2+ was alpha1-subunit-dependent with lowest value for CaV1.2, and highest for CaV3.1; the sensitivity of the channels to Zn2+ was approximately ranked as CaV1.2>CaV3.2>CaV2.3>CaV2.2=CaV 2.1>or=CaV3.3=CaV3.1. Although the CaV2.2 and CaV3.1 channels had similar IC50 for Zn2+ in Ba2+, the CaV2.2, but not CaV3.1 channels, had approximately 10-fold higher IC50 to Zn2+ in Ca2+. The reduced sensitivity of CaV2.2 channels to Zn2+ in Ca2+ was partially reversed by disrupting a putative EF-hand motif located external to the selectivity filter EEEE locus. Thus, our findings support the notion that the Zn2+ block, mediated by multiple mechanisms, may depend on conformational changes surrounding the alpha1 pore regions. These findings provide fundamental insights into the mechanism underlying the inhibitory effect of zinc on various Ca2+ channel subtypes.

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Section: Introductionmentioning

confidence: 99%

Zn2+ Sensitivity of High- and Low-Voltage Activated Calcium Channels

Sun

Hui

Lee

et al. 2007

Biophysical Journal

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Health Outcomes of Exposure to Biological and Chemical Components of Inhalable and Respirable Particulate Matter

Morakinyo

Mokgobu

Mukhola

et al. 2016

IJERPH

160

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Particulate matter (PM) is a key indicator of air pollution and a significant risk factor for adverse health outcomes in humans. PM is not a self-contained pollutant but a mixture of different compounds including chemical and biological fractions. While several reviews have focused on the chemical components of PM and associated health effects, there is a dearth of review studies that holistically examine the role of biological and chemical components of inhalable and respirable PM in disease causation. A literature search using various search engines and (or) keywords was done. Articles selected for review were chosen following predefined criteria, to extract and analyze data. The results show that the biological and chemical components of inhalable and respirable PM play a significant role in the burden of health effects attributed to PM. These health outcomes include low birth weight, emergency room visit, hospital admission, respiratory and pulmonary diseases, cardiovascular disease, cancer, non-communicable diseases, and premature death, among others. This review justifies the importance of each or synergistic effects of the biological and chemical constituents of PM on health. It also provides information that informs policy on the establishment of exposure limits for PM composition metrics rather than the existing exposure limits of the total mass of PM. This will allow for more effective management strategies for improving outdoor air quality.

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Metal Particulate Matter Components Affect Gene Expression and Beat Frequency of Neonatal Rat Ventricular Myocytes

Cited by 2 publications

References 9 publications

Zn2+ Sensitivity of High- and Low-Voltage Activated Calcium Channels

Zn2+ Sensitivity of High- and Low-Voltage Activated Calcium Channels

Health Outcomes of Exposure to Biological and Chemical Components of Inhalable and Respirable Particulate Matter

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