Metal–phenolic network composites: from fundamentals to applications

Lin, Zhixing; Liu, Hai; Richardson, Joseph J.; Xu, Wanjun; Chen, Jingqu; Zhou, Jiajing; Caruso, Frank

doi:10.1039/d3cs00273j

Chem. Soc. Rev.

2024

DOI: 10.1039/d3cs00273j

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Metal–phenolic network composites: from fundamentals to applications

Zhixing Lin,

Hai Liu,

Joseph J. Richardson

et al.

Abstract: This review provides a guideline for the rational design of metal–phenolic network (MPN) composites—which are fabricated from MPN and one or more functional components (e.g., drugs, proteins)—for various applications across diverse disciplines.

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Cited by 3 publications

References 176 publications

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Truxillic calcium supramolecular skeleton fortified pH responsive and biodegradable alginate hydrogel films promoting fruit preservation

Zhang,

Kong

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International Journal of Biological Macromolecules

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Truxillic calcium supramolecular skeleton fortified pH responsive and biodegradable alginate hydrogel films promoting fruit preservation

Zhang,

Kong

et al. 2025

International Journal of Biological Macromolecules

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Metal-phenolic network biointerface-mediated cell regulation for bone tissue regeneration

Wang,

Li,

et al. 2025

Materials Today Bio

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Assembly and biological functions of metal-biomolecule network nanoparticles formed by metal-phosphonate coordination

Xu,

Lin,

Kim

et al. 2024

Sci. Adv.

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Metal-organic networks have attracted widespread interest owing to their hybrid physicochemical properties. Natural biomolecules represent attractive building blocks for these materials because of their inherent biological function and high biocompatibility; however, assembling them into coordination network materials, especially nanoparticles (NPs), is challenging. Herein, we exploit the coordination between metal ions and phosphonate groups, which are present in many biomolecules, to form metal-biomolecule network (MBN) NPs in aqueous solution at room temperature. Various phosphonate-containing biomolecules, including plant phytate, DNA, and proteins, were used to assemble MBN NPs with tunable physicochemical properties (e.g., size). In addition to excellent biocompatibility and high cargo-loading efficiency (>95%), these two-component MBN NPs have various biological functionalities, including endosomal escape, immune regulation, and molecular recognition, thus offering advantages over nonbiomolecular-based coordination materials. This work expands our understanding of metal-organic chemistry with the emerging class of metal-biomolecule systems and provides a pathway for incorporating biofunctionalities into advanced coordination materials for diverse fields.

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Metal–phenolic network composites: from fundamentals to applications

Abstract: This review provides a guideline for the rational design of metal–phenolic network (MPN) composites—which are fabricated from MPN and one or more functional components (e.g., drugs, proteins)—for various applications across diverse disciplines.

Cited by 3 publications

References 176 publications

Truxillic calcium supramolecular skeleton fortified pH responsive and biodegradable alginate hydrogel films promoting fruit preservation

Truxillic calcium supramolecular skeleton fortified pH responsive and biodegradable alginate hydrogel films promoting fruit preservation

Metal-phenolic network biointerface-mediated cell regulation for bone tissue regeneration

Assembly and biological functions of metal-biomolecule network nanoparticles formed by metal-phosphonate coordination

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