Metal–phenolic networks acted as a novel bio-filler of a barrier membrane to improve guided bone regeneration<i>via</i>manipulating osteoimmunomodulation

Ren, Lulu; Gong, Pei; Gao, Xinghui; Wang, Qian; Xie, Li; Tang, Wei; Long, Jie; Liu, Can; Tian, Weidong; He, Min

doi:10.1039/d2tb01804g

Cited by 8 publications

(2 citation statements)

References 37 publications

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“…In contrast, M2-polarized macrophages produce various anti-inflammatory and pro-healing factors, which are beneficial for bone regeneration . Accumulative evidence has highlighted that biomaterials with immunomodulatory properties could orchestrate the sequential activation of macrophages to promote the rapid resolution of inflammation and guarantee the predominance of M2-polarized macrophages to launch a successful osseointegration process. − …”

Section: Results and Discussionmentioning

confidence: 99%

Janus Membrane with Intrafibrillarly Strontium-Apatite-Mineralized Collagen for Guided Bone Regeneration

Zhao,

Sun,

et al. 2024

ACS Nano

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Commercial collagen membranes face difficulty in guided bone regeneration (GBR) due to the absence of hierarchical structural design, effective interface management, and diverse bioactivity. Herein, a Janus membrane called SrJM is developed that consists of a porous collagen face to enhance osteogenic function and a dense face to maintain barrier function. Specifically, biomimetic intrafibrillar mineralization of collagen with strontium apatite is realized by liquid precursors of amorphous strontium phosphate. Polycaprolactone methacryloyl is further integrated on one side of the collagen as a dense face, which endows SrJM with mechanical support and a prolonged lifespan. In vitro experiments demonstrate that the dense face of SrJM acts as a strong barrier against fibroblasts, while the porous face significantly promotes cell adhesion and osteogenic differentiation through activation of calciumsensitive receptor/integrin/Wnt signaling pathways. Meanwhile, SrJM effectively enhances osteogenesis and angiogenesis by recruiting stem cells and modulating osteoimmune response, thus creating an ideal microenvironment for bone regeneration.In vivo studies verify that the bone defect region guided by SrJM is completely repaired by newly formed vascularized bone. Overall, the outstanding performance of SrJM supports its ongoing development as a multifunctional GBR membrane, and this study provides a versatile strategy of fabricating collagen-based biomaterials for hard tissue regeneration.

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Section: Results and Discussionmentioning

confidence: 99%

Janus Membrane with Intrafibrillarly Strontium-Apatite-Mineralized Collagen for Guided Bone Regeneration

Zhao,

Sun,

et al. 2024

ACS Nano

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“…Then a few studies reported polyphenol‐Sr modified membranes or scaffolds, investigating their effect on the bone regeneration process or osteoarthritis. [ 37 , 38 ] The influence on the interfacial osseointegration around the implant surface remains unclear. Considering that MPN is biosafe and biodegradable in the physiological microenvironment, it is expected that TA‐Sr‐based MPN can offer an osteoimmunomodulation biointerface to improve the early integration of Ti implants.…”

Section: Introductionmentioning

confidence: 99%

A Multifunctional Metal–Phenolic Nanocoating on Bone Implants for Enhanced Osseointegration via Early Immunomodulation

Liu,

Shi,

Zhao

et al. 2024

Advanced Science

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Surface modification is an important approach to improve osseointegration of the endosseous implants, however it is still desirable to develop a facile yet efficient coating strategy. Herein, a metal–phenolic network (MPN) is proposed as a multifunctional nanocoating on titanium (Ti) implants for enhanced osseointegration through early immunomodulation. With tannic acid (TA) and Sr2+ self‐assembled on Ti substrates, the MPN coatings provided a bioactive interface, which can facilitate the initial adhesion and recruitment of bone marrow mesenchymal stem cells (BMSCs) and polarize macrophage toward M2 phenotype. Furthermore, the TA‐Sr coatings accelerated the osteogenic differentiation of BMSCs. In vivo evaluations further confirmed the enhanced osseointegration of TA‐Sr modified implants via generating a favorable osteoimmune microenvironment. In general, these results suggest that TA‐Sr MPN nanocoating is a promising strategy for achieving better and faster osseointegration of bone implants, which can be easily utilized in future clinical applications.

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Poly(terephthalic acid diallyl ester) embedded by tantalum microspheres (PTADE@Ta) for precise and long-term X-ray imaging in the embolization

Xiao,

Ai,

Chen

et al. 2024

Polym. Bull.

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Metal–phenolic networks acted as a novel bio-filler of a barrier membrane to improve guided bone regenerationviamanipulating osteoimmunomodulation

Abstract: Guided bone tissue regeneration membrane (GBRM) is traditionally viewed as an inert physical barrier to isolate soft tissue from bone defect area. However, as a “foreign body”, the implantation of...

Cited by 8 publications

References 37 publications

Janus Membrane with Intrafibrillarly Strontium-Apatite-Mineralized Collagen for Guided Bone Regeneration

Janus Membrane with Intrafibrillarly Strontium-Apatite-Mineralized Collagen for Guided Bone Regeneration

A Multifunctional Metal–Phenolic Nanocoating on Bone Implants for Enhanced Osseointegration via Early Immunomodulation

Poly(terephthalic acid diallyl ester) embedded by tantalum microspheres (PTADE@Ta) for precise and long-term X-ray imaging in the embolization

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