Recent clinical failures and abnormal sounds observed in certain prosthetic hip designs have directed attention to adverse condition hip simulator testing. In the present study, hip simulator wear and friction tests were made with a macroscopic separation of the bearing surfaces in the swing phase, steep acetabular cup position, increased load, poor or lacking lubrication, roughened bearing surfaces including titanium third bodies, and with combinations of these. The only conditions that resulted in squeaking were dry sliding with alumina-on-alumina and metal-on-metal, and an extreme peak load of 4 kN with serum lubricated metal-on-metal. The wear rate of metal-on-metal increased by an order of magnitude when the cup position was steep, 64 degrees, compared with the optimal position of 48 degrees. The increase of the peak load from 2 kN to 3 kN with the cup position of 48 degrees increased the running-in wear of metal-on-metal, but the steady state wear rates were equally low, of the order of 1 mg per one million cycles. Crosslinked polyethylene was the superior cup material under adverse conditions, including dry sliding and roughened femoral head.