Metal release from various grades of stainless steel exposed to synthetic body fluids

Herting, Gunilla; Wallinder, Inger Odnevall; Leygraf, Christofer

doi:10.1016/j.corsci.2006.05.008

Cited by 69 publications

(75 citation statements)

References 16 publications

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“…Both fluids have been identified to cause degradation of plastic implant materials [29,30]. Artificial Lysosomal Fluid (ALF) simulates the immunological reaction of the body while the Gamble's solution is similar to the interstitial fluid of the deep lung.…”

Section: In-vitro Degradation Testmentioning

confidence: 99%

The influence of Ag+, Zn2+ and Cu2+ exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethane

Kaali¹,

Pérez-Madrignal²,

Strömberg³

et al. 2011

Express Polym. Lett.

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This study aims to investigate the limitations and applicability of different ion exchanged zeolites as antimicrobial additive in thermoplastic polyether type polyurethanes. These composites were designed to improve the health quality of hospitalized patients by expressing both biocompatibility and relevant antimicrobial activity. The zeolites were exchanged with silver, copper and zinc ions and single, binary and ternary ion-exchanged zeolite-polyurethane composites were prepared. The antimicrobial activity and the resistance of the composites against the human environment play vital role in the applicability of the materials as a medical device therefore these properties were investigated. The antimicrobial test were performed on Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa and Candida tropicalis. The tests showed that the efficiency of the silver ions is superior to the other single ionic systems. Besides, the binary and ternary ion-exchanged samples had similar antimicrobial efficiency regardless the type of the ions in the zeolite. The biocompatibility tests were carried out in-vitro in artificial body fluids for a period of 12 weeks. As a result of the invitro test, degradation of the composites were observed and the structural changes of the materials were detected and described by Scanning Electron Microscopy, Contact Angle measurements and Attenuated Total Reflection Fourier Transform Infrared Spectroscopy

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Section: In-vitro Degradation Testmentioning

confidence: 99%

The influence of Ag+, Zn2+ and Cu2+ exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethane

Kaali¹,

Pérez-Madrignal²,

Strömberg³

et al. 2011

Express Polym. Lett.

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show abstract

“…Maloney et al, have measured in-vivo 5 dissolution rates of silica as 3.5 nm per day (1,277 nm per year) for plasma enhanced chemical vapor deposition (PECVD) 6 silicon oxide [12]. Maloney et al, have plotted the film thinning over time and the rate of silica dissolution appears to be linear with time.…”

Section: In-vivomentioning

confidence: 99%

“…5 In-vivo testing was done by implanting the chips in the back of rats for up to 300 days. 6 Deposition temperature was 350°C and 1,060 nm thickness of silica was deposited. The precursors for the silicon oxide film were SiH 4 , N 2 O, He, and N 2 , and the deposition rate [Maloney, 2005].…”

Section: Factors Affecting Dissolution Of Silicamentioning

confidence: 99%

“…Pre-exposure to Gamble's solution for 8 to 24 hours reduces the total metal ion leaching rate during one week's exposures to the higher pH ALF solutions. This suggests that calcium and phosphate deposit during the preexposure to Gamble's solution at pH 7.5 and act to limit further metal ion leaching [6], [7].…”

Section: Introductionmentioning

confidence: 99%

“…Stainless steels, cobalt-chromium, and nitinol alloys are commonly used in implantable medical devices. Herting et al, has investigated the effect of various simulate physiological solutions (Gamble's solution and ALF artificial lysosomal fluid) on the rate of metal ion leaching from various stainless steels [6]. They found metal dissolution decreases with exposure time and for stainless steels the metal ion leaching rate is faster at pH 4.5 than at 7.4.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ion Leaching from Implantable Medical Devices

Eiselstein

Caligiuri

2010

MSF

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Abstract. Implantable medical devices must be able to withstand the corrosive environment of the human body for 10 or more years without adverse consequences. Most reported research and development has been on developing materials and devices that are biocompatible and resistant to corrosion-fatigue, pitting, and crevice corrosion. However, little has been directly reported regarding implantable materials with respect to the rate at which they generate soluble ions in-vivo. Most of the biocompatibility studies have been done by examining animal implants and cell cultures rather than examining the rate at which these materials leach ions into the body. This paper will discuss what is currently known about the rate at which common implant materials (such as stainless steels, cobalt-chromium alloys, and nitinol) elute ions under in vitro conditions, what the limitations are of such data, and how this data can be used in medical device development.

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Corrosion of Shape Memory and Superelastic Alloys

Eiselstein

2011

Uhlig's Corrosion Handbook

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Metal release from various grades of stainless steel exposed to synthetic body fluids

Cited by 69 publications

References 16 publications

The influence of Ag+, Zn2+ and Cu2+ exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethane

The influence of Ag+, Zn2+ and Cu2+ exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethane

Ion Leaching from Implantable Medical Devices

Corrosion of Shape Memory and Superelastic Alloys

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