Metales pesados en el ambiente: síndrome de Guillain-Barré like

Gaioli, Graciela M; González, Daniel; Areny, Giselle; Grela, Marcelo; Amoedo, Diego

doi:10.5546/aap.2020.e48

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Additionally, chronic or acute exposure to mercury has been reported to cause Guillain–Barre syndrome (GBS) in isolated cases. 2 Because multiple organs are involved in mercury poisoning, we reasonably presumed that MN and GBS were not coincidental concurrent illnesses that occurred after mercury exposure in our patient. Here, we describe a case of mercury toxicity complicated by peripheral neuropathy and nephrotic syndrome.…”

Section: Introductionmentioning

confidence: 83%

“…Gaioli et al presented a 14-year-old patient with acute, symmetric, ascending, and progressive muscle weakness who was diagnosed with GBS and did not respond to conventional treatment. 2 Considering the etiology, heavy metal neuropathy was suspected, and then mercury poisoning from a fluorescent lamp was confirmed. Swaiman et al described a 14-year-old boy who developed acrodynia and then GBS from mercury vapor poisoning.…”

Section: Discussionmentioning

confidence: 99%

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Mercury as a cause of membranous nephropathy and Guillain–Barre syndrome: case report and literature review

et al. 2021

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Secondary renal involvement in chronic exposure to metallic mercury is well known. Mercury also causes central nervous system damage and demyelinating polyneuropathy. Here, we describe a case of a patient with daily exposure to mercury in skin lightening cream and hair dyes who was diagnosed with Guillain–Barre syndrome and then developed nephrotic syndrome because of membranous neuropathy. By reviewing the literature describing mercury-associated diseases, we found that mercury components have an immunomodulatory activity, which is also involved in both peripheral neuropathy and glomerulonephritis.

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Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Mercury as a cause of membranous nephropathy and Guillain–Barre syndrome: case report and literature review

et al. 2021

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The impact of chronic co-exposure to different heavy metals on small fibers of peripheral nerves. A study of metal industry workers

Koszewicz

Markowska

Waliszewska‐Prosół

et al. 2021

J Occup Med Toxicol

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Background Chronic exposure to heavy metals affects various organs, among them the brain and peripheral nerves. Polyneuropathy is mainly length-dependent with predominantly sensory symptoms. There have been few studies on small fiber neuropathy due to heavy metal intoxication. Methods We investigated 41 metal industry workers, mean age 51.3 ± 10.5 years, with at least 5 years’ professional exposure to heavy metals, and 36 age- and sex-matched healthy controls. We performed neurological examinations, and assessed blood levels of cadmium, lead, and zinc protoporphyrin, urine levels of arsenic, standard, sensory and motor electrophysiological tests in the ulnar and peroneal nerves, sympathetic skin responses from the palm and foot, and quantitative sensation testing from dermatomes C8 and S1. Discussion The results of standard conduction tests of all nerves significantly differed between groups. The latency of sympathetic skin responses achieved from the foot was also statistically significantly prolonged in the study group. Significant differences were seen in both C8 and S1 regions for temperature and pain thresholds, and for vibratory threshold only in the S1 region, while the dispersions of low and high temperatures were important exclusively in the C8 region. Conclusions We can conclude that co-exposure to many heavy metals results in explicit impairment of peripheral nerves. The lesion is more pronounced within small fibers and is predominantly connected with greater impairment of temperature-dependent pain thresholds. The evaluation of small fiber function should be considered in the early diagnosis of toxic polyneuropathy or in low-dose exposure to heavy metals.

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Metales pesados en el ambiente: síndrome de Guillain-Barré like

Cited by 2 publications

References 6 publications

Mercury as a cause of membranous nephropathy and Guillain–Barre syndrome: case report and literature review

Mercury as a cause of membranous nephropathy and Guillain–Barre syndrome: case report and literature review

The impact of chronic co-exposure to different heavy metals on small fibers of peripheral nerves. A study of metal industry workers

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