Metallic nanoformulations: Green synthetic approach for advanced drug delivery

Usmani, Afreen; Dash, Pragyandip Parthasarathi; Mishra, Anuradha

doi:10.18063/msacm.v2i1.729

Cited by 9 publications

(5 citation statements)

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“…Therefore, determining the conditions suitable for the biosynthesis of inorganic nanoparticles is achieved through varying the parameters mentioned above. Furthermore, the essential phytochemicals with antioxidant activity in the plant extract affect the physicochemical properties of the biosynthesized nanoparticles, and the antioxidants present vary from species to species ( Usmani et al, 2018 ; Akintelu et al, 2020 ). Camellia sinensis extract (CSE) and Prunus africana extract (PAE) are rich in phytochemicals with strong free radical scavenging activity and medical importance.…”

Section: Introductionmentioning

confidence: 99%

Phyto-Mediated Copper Oxide Nanoparticles for Antibacterial, Antioxidant and Photocatalytic Performances

Ssekatawa

Byarugaba

Angwe

et al. 2022

Front. Bioeng. Biotechnol.

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The greatest challenge of the current generation and generations to come is antimicrobial resistance, as different pathogenic bacteria have continuously evolved to become resistant to even the most recently synthesized antibiotics such as carbapenems. Resistance to carbapenems limits the therapeutic options of MDR infections as they are the only safe and effective drugs recommended to treat such infections. This scenario has complicated treatment outcomes, even to the commonest bacterial infections. Repeated attempts to develop other approaches have been made. The most promising novel therapeutic option is the use of nanomaterials as antimicrobial agents. Thus, this study examined the efficacy of Camellia sinensis extract (CSE) and Prunus africana bark extract (PAE) green synthesized Copper oxide nanoparticles (CuONPs) against carbapenem-resistant bacteria. Furthermore, the photocatalytic and antioxidant activities of CuONPs were evaluated to determine the potential of using them in a wide range of applications. CuONPs were biosynthesized by CSE and PAE. UV vis spectroscopy, X-ray Diffraction (XRD), Dynamic light scattering (DLS), Fourier Transform Infrared spectroscopy (FTIR), and Scanning Electron Microscopy (SEM) were used to characterize the nanoparticles. CuONPs susceptibility tests were carried out by the agar well diffusion method. The photocatalytic and antioxidant activities of the CuONPs were determined by the methylene blue and DPPH free radical scavenging assays, respectively. UV vis absorbance spectra registered surface plasmon resonance peaks between 272 and 286 nm, confirming the presence of CuONPs. The XRD array had nine strong peaks at 2θ values typical of CuONPs. FTIR spectra exhibited bands associated with organic functional groups confirming capping and functionalization of the CuONPs by the phytochemicals. DLS analysis registered a net zeta potential of +12.5 mV. SEM analysis revealed that the nanoparticles were spherical and clustered with a mean diameter of 6 nm. Phytosynthesized CuONPs exhibited the highest growth suppression zones of 30 mm with MIC ranging from 30 to 125 μg/ml against MDR bacteria. Furthermore, the CuONPs achieved a methylene blue dye photocatalysis degradation efficiency of 85.5% and a free radical scavenging activity of 28.8%. PAE and CSE successfully bio-reduced copper ions to the nanoscale level with potent antimicrobial, photocatalysis, and antioxidant activities.

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Section: Introductionmentioning

confidence: 99%

Phyto-Mediated Copper Oxide Nanoparticles for Antibacterial, Antioxidant and Photocatalytic Performances

Ssekatawa

Byarugaba

Angwe

et al. 2022

Front. Bioeng. Biotechnol.

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“…The reaction parameters include the concentration of silver nitrate, volume/concentration of plant extract, reaction temperature, reaction period, and pH of the reaction mixture. The properties of biosynthesized AgNPs greatly depend on the optimization of the reaction parameters (Usmani et al, 2018). Suitable pH values for AgNPs biosynthesis range from 2 to 14; however, a pH value of 7 has been documented as optimal for the complete reduction of Ag + to Ag 0 .…”

Section: Introductionmentioning

confidence: 99%

Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications

Ssekatawa

Byarugaba

Kato

et al. 2021

Front. Nanotechnol.

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Antibiotics have been the nucleus of chemotherapy since their discovery and introduction into the healthcare system in the 1940s. They are routinely used to treat bacterial infections and to prevent infections in patients with compromised immune systems and enhancing growth in livestock. However, resistance to last-resort antibiotics used in the treatment of multidrug-resistant infections has been reported worldwide. Therefore, this study aimed to evaluate green synthesized nanomaterials such as silver nanoparticles (AgNPs) as alternatives to antibiotics. UV-vis spectroscopy surface plasmon resonance peaks for AgNPs were obtained between 417 and 475 nm. An X-ray diffraction analysis generated four peaks for both Prunus africana extract (PAE) and Camellia sinensis extract (CSE) biosynthesized AgNPs positioned at 2θ angles of 38.2°, 44.4°, 64.5°, and 77.4° corresponding to crystal planes (111), (200), (220), and (311), respectively. A dynamic light-scattering analysis registered the mean zeta potential of +6.3 mV and +0.9 mV for PAE and CSE biosynthesized nanoparticles, respectively. Fourier transform infrared spectroscopy spectra exhibited bands corresponding to different organic functional groups confirming the capping of AgNPs by PAE and CSE phytochemicals. Field emission scanning electron microscopy imaging showed that AgNPs were spherical with average size distribution ranging from 10 to 19 nm. Biosynthesized AgNPs exhibited maximum growth inhibitory zones of 21 mm with minimum inhibitory concentration and minimum bactericidal concentration of 125 and 250 μg/ml, respectively, against carbapenem-resistant bacteria.

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“…h. Education and awareness: As green nanoparticles are relatively new, educating researchers, industries, and the public about their benefits, limitations, and responsible use is crucial for their successful integration into various sectors [79].…”

Section: Perspectivesmentioning

confidence: 99%

Green Synthesis of Copper, Silver, and Gold Nanoparticles: Applications in Medicinal Chemistry

Nawaz,

Jamil,

Shakoor

2023

Green Chemistry for Environmental Sustainability - Prevention-Assurance-Sustainability (P-a-S) Approach

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For the creation of an effective “green chemistry,” scientists have paid a lot of attention to a method for creating metal nanoparticles in recent years. The topic of nanoscale metal synthesis is one that is now pertinent due to the growing use of nanoscale metals in industries like engineering and medicine and the environment. The development of nanotechnology has revolutionized society and has focused on a number of scientific fields, including cancer, human epidemiology, and material science. Utilizing biological agents to prepare metallic nanoparticles through green chemistry reduces negative effects and improves the metal’s anticancer properties. Commercially, nanoparticles are typically prepared via physical, chemical, and biological techniques. For metal and metal oxide nanoparticles made from natural extracts, such as gold, silver, and copper oxide, which are useful to improve biomedical applications like antibacterial, antifungal, and antioxidant, have been summarized in this chapter. The easy availability of plants that are safe, easy to handle, and inexpensive allows for the synthesis of many nanoparticles. These techniques are environment-friendly, nontoxic, and economically viable green synthesized processes.

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Metallic nanoformulations: Green synthetic approach for advanced drug delivery

Cited by 9 publications

References 0 publications

Phyto-Mediated Copper Oxide Nanoparticles for Antibacterial, Antioxidant and Photocatalytic Performances

Phyto-Mediated Copper Oxide Nanoparticles for Antibacterial, Antioxidant and Photocatalytic Performances

Green Strategy–Based Synthesis of Silver Nanoparticles for Antibacterial Applications

Green Synthesis of Copper, Silver, and Gold Nanoparticles: Applications in Medicinal Chemistry

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