Metallic nanostructure-based aptasensors for robust detection of proteins

Rabiee, Navid; Ahmadi, Sepideh; Rahimizadeh, Kamal; Chen, Suxiang; Veedu, Rakesh N.

doi:10.1039/d3na00765k

Cited by 9 publications

(2 citation statements)

References 137 publications

(161 reference statements)

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“…The quest for ultrasensitive and highly selective sensors is essential in the early detection for monitoring amyloid diseases and effective treatment. 26 However, developing sensitive and reliable detection techniques faces challenges due to the low concentrations of diagnostic biomarkers and the cross-reactivity between monomers and oligomers. 27 To enhance sensing performance in terms of sensitivity, selectivity, and response speed, researchers have explored a wide range of materials, including carbon-based nanomaterials, 28 conductive polymers, 29 quantum dots, 30 noble metals, 31 and MOFs.…”

Section: Introductionmentioning

confidence: 99%

Amyloid detection in neurodegenerative diseases using MOFs

Maru,

Singh,

Jangir

et al. 2024

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

Amyloid detection in neurodegenerative diseases using MOFs

Maru,

Singh,

Jangir

et al. 2024

J. Mater. Chem. B

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“…Furthermore, with advancements in nanotechnology, the design and selection of nanoparticles for the surface functionalization of an electrode are crucial, as they possess unique optical, electrical, thermal, and catalytic properties that can significantly influence sensing performance. These nanomaterials can be metallic nanoparticles [ 7 ], carbon nanotubes [ 8 ], or nanoparticles made of semiconductor materials [ 9 ]. The latter have dimensions comparable to the dimensions of biomolecules (enzymes, antigens/antibodies, DNA, etc.…”

Section: Introductionmentioning

confidence: 99%

Novel and Extremely Sensitive NiAl2O4-NiO Nanostructures on an ITO Sensing Electrode for Enhanced Detection of Ascorbic Acid

Hammami,

Bardaoui,

Eissa

et al. 2024

Molecules

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The current study focused on the design of an extremely sensitive electrochemical sensor of ascorbic acid based on a mixture of NiAl2O4-NiO nanoparticles that, produced in a single step using the sol–gel method, on an ITO electrode. This new sensing platform is useful for the detection of ascorbic acid with a wide range of concentrations extending from the attomolar to the molar. SEM micrographs show the porous structure of the NiAl2O4-NiO sample, with a high specific surface area, which is beneficial for the catalytic performance of the nanocomposite. An XRD diffractogram confirmed the existence of two phases, NiAl2O4 and NiO, both corresponding to the face-centred cubic crystal structure. The performances of the modified electrode, as a biomolecule, in the detection of ascorbic acid was evaluated electrochemically by cyclic voltammetry and chronoamperometry. The sensor exhibited a sensitive electrocatalytic response at a working potential of E = +0.3 V vs. Ag/Ag Cl, reaching a steady-state current within 30 s after each addition of ascorbic acid solution with a wide dynamic range of concentrations extending from attolevels (10−18 M) to molar (10 mM) and limits of detection and quantification of 1.2 × 10−18 M and 3.96 × 10−18 M, respectively. This detection device was tested for the quantification of ascorbic acid in a 500 mg vitamin C commercialized tablet that was not pre-treated.

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Light‐Driven Multi‐Core/Shell Microdroplets as a Targeted Drug Delivery System

Yuan,

Yao,

Yang

et al. 2024

Adv Funct Materials

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Targeted drug delivery system (DDS) holds exciting prospects in biomedical clinical research and drug development. However, it faces a significant challenge in achieving stable and safe targeted transportation without drug leakage while obtaining precise and controllable drug dosing with a high drug utilization rate and low side effects. Herein, an optical tweezers‐based light‐driven technique is proposed to transport and construct multi‐core/shell microdroplets enveloping drug carriers and target cells as a novel, safe, and efficient targeted DDS. Drug‐loaded microdroplets with core/shell structures are first fabricated by a new and simple injection extrusion method and then it is transported to a target cell by a dynamic optical trap with a low optical power, which ensures no drug leakage, exogenous materials, and biothermal damage are introduced during the drug delivery process. Next, precise drug dosing is realized by pushing the target cell into the drug‐loaded microdroplet under the actions of optical forces, which constructs a multi‐core/shell microdroplet structure with a pure drug environment to improve the drug action efficiency. Moreover, quantitative drug dosing with a high drug utilization rate can also achieved by controlling the sizes/number of drug droplets inside the microdroplets. This light‐driven DDS is of great interest to frontier medical research and disease treatment fields.

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Metallic nanostructure-based aptasensors for robust detection of proteins

Abstract: There is a significant need for rapid, cost-effective, and highly sensitive protein target detection, particularly in the fields of food, environmental monitoring, and healthcare. The integration of high-affinity aptamers with...

Cited by 9 publications

References 137 publications

Amyloid detection in neurodegenerative diseases using MOFs

Amyloid detection in neurodegenerative diseases using MOFs

Novel and Extremely Sensitive NiAl2O4-NiO Nanostructures on an ITO Sensing Electrode for Enhanced Detection of Ascorbic Acid

Light‐Driven Multi‐Core/Shell Microdroplets as a Targeted Drug Delivery System

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