Metallocarbonyl complexes: (η5-C5H5)M(CO)n(η1-N-imidato) (M = Fe, Ru, Mo, W; n = 2, 3) as new photoactive CO-releasing molecules (CORMs)

Kubicka, Aleksandra; Parfieniuk, Ewa; Fornal, Emilia; Palusiak, Marcin; Lizińska, Daria; Gumieniczek, Anna; Rudolf, Bogna

doi:10.1016/j.jphotochem.2017.10.012

Cited by 12 publications

(7 citation statements)

References 27 publications

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“…Some of us have already reported that the irradiation of iron metallocarbonyl complexes led to degradation of complex and released of CO and free imide. [ 19,36 ]…”

Section: Resultsmentioning

confidence: 99%

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Cytotoxicity of piano‐stool ruthenium cyclopentadienyl complexes bearing different imidato ligands

Juszczak

Kluska

Kosińska

et al. 2022

Applied Organom Chemis

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In these studies, we investigated a cytotoxic and genotoxic potential of four ruthenium cyclopentadienyl complexes bearing different imidato ligands: (η5‐cyclopentadienyl)Ru (CO)2(η1‐N‐maleimidato) (1), (η5‐cyclopentadienyl)Ru (CO)2‐N‐methoxysuccinimidato (2), (η5‐cyclopentadienyl)Ru (CO)2‐N‐ethoxysuccinimidato (3), and (η5‐cyclopentadienyl)Ru (CO)2‐N‐phthalimidato (4). We used two types of cells—normal peripheral blood mononuclear cells (PBMCs) and leukemic HL‐60 cells. We observed that complex 1 was highly cytotoxic and genotoxic, both for normal and cancer cells at concentrations from 0.5 to 250 μM. Interestingly, complex 1 was 10 times more cytotoxic to HL‐60 cells compared with PBMCs. Complexes 2–4 were cytotoxic only for HL‐60 cells at the highest used concentrations. Furthermore, we observed an increase in the viability of PBMCs after incubation with succinimide complexes 2 and 3. We also showed that complex 1 arrested cell cycle in the sub‐G1 phase and induced apoptosis. We found that different properties of studied ruthenium complexes depend significantly on the type of imide ligand bind to the ruthenium atom. The density functional theory (DFT) calculation of maleimide and succinimide revealed some significant differences of these compounds that would be related to biological activity. Our results indicate that ruthenium complex 1 should be further investigated in detail for its anticancer properties.

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“…Some of us have already reported that the irradiation of iron metallocarbonyl complexes led to degradation of complex and released of CO and free imide. [ 19,36 ]…”

Section: Resultsmentioning

confidence: 99%

“…Some of us have already reported that the irradiation of iron metallocarbonyl complexes led to degradation of complex and released of CO and free imide. [19,36] We also determined the effect of free imidesmaleimide, succinimide, and their N-substituted derivatives (Figure S7) on the viability of PBMCs and HL-60 cells.…”

Section: Cell Viabilitymentioning

confidence: 99%

Cytotoxicity of piano‐stool ruthenium cyclopentadienyl complexes bearing different imidato ligands

Juszczak

Kluska

Kosińska

et al. 2022

Applied Organom Chemis

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“…The incubation time was equal to halflives of the conversion of deoxy-Mb to Mb-CO after addition of complexes A or B and irradiation with visible light. 34 The cells were irradiated with light in the wavelength range of 450 to 650 nm by using the Q•Light Pro Unit lamp. The distance from the light source was 20 cm.…”

Section: Cell Treatmentmentioning

confidence: 99%

“…33 Recent studies have shown that complexes bearing imidato ligands are photoactive CO-releasing molecules. 34 The (η 5…”

Section: Introductionmentioning

confidence: 99%

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Photoactive CO-releasing complexes containing iron – genotoxicity and ability in HO-1 gene induction in HL-60 cells

et al. 2019

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Increasing the CO‐Release Photosensitivity of Mn(I) Carbonyl Complexes Towards Longer Wavelengths by Electronically Tuning Their Schiff Base Ligands

Li,

Ma,

Xiao

et al. 2024

Applied Organom Chemis

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Five novel manganese (I) tricarbonyl complexes were synthesized by the reaction of Mn (CO)5Br with quinoline‐2‐carboxaldehyde and different anilines. The IR, UV, and myoglobin results indicate that these complexes can be used as photoCORMs (photo photoinduced carbon monoxide releasing molecules) activated by red light. The visible range spectra display strong charge transfer (CT) bands, the maxima of which are sensitive to the ligand substituents. Density functional theory (DFT) and time‐dependent density functional theory (TDDFT) computations show that these CT transitions are admixtures of metal‐to‐ligand and aniline‐to‐quinoline charge transfers and that increasing the electron‐donating ability on the aniline functionality can lead to shifts in the absorption bands of the corresponding compounds to longer wavelengths and to enhanced band intensities, thus enhancing their photoactivity. Photolysis of these complexes in aerobic solution leads to CO photodissociation followed by oxidation of the Mn(I) center to Mn(II).

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Metallocarbonyl complexes: (η5-C5H5)M(CO)n(η1-N-imidato) (M = Fe, Ru, Mo, W; n = 2, 3) as new photoactive CO-releasing molecules (CORMs)

Cited by 12 publications

References 27 publications

Cytotoxicity of piano‐stool ruthenium cyclopentadienyl complexes bearing different imidato ligands

Cytotoxicity of piano‐stool ruthenium cyclopentadienyl complexes bearing different imidato ligands

Photoactive CO-releasing complexes containing iron – genotoxicity and ability in HO-1 gene induction in HL-60 cells

Increasing the CO‐Release Photosensitivity of Mn(I) Carbonyl Complexes Towards Longer Wavelengths by Electronically Tuning Their Schiff Base Ligands

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