Metalloenzyme mimicry and modulation strategies to conquer antimicrobial resistance: Metal-ligand coordination perspectives

Ayipo, Yusuf Oloruntoyin; Osunniran, Wahab Adesina; Babamale, Halimah Funmilayo; Ayinde, Monsurat Olabisi; Mordi, Mohd Nizam

doi:10.1016/j.ccr.2021.214317

Cited by 22 publications

(13 citation statements)

References 102 publications

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“…Such methyl esters may directly downregulate the Bcl-2 protein expression in cells [ 75 ]. Spiro[2.4]hept-5-ene,5-trimethylsilyl methyl-1-trimethylsilyl-, and Octanedioic acid have been reported to possess enormous antimicrobial activity against several human and animal pathogens in vitro [ 76 , 77 , 78 , 79 ]. Ethyl acetate and methanol extract exhibited a reasonable quantity of (BHT) Butylated Hydroxytoluene ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Pharmacological Activity, and Comparison GC-ToF-MS Profiling of Extracts from Cissus cornifolia (Baker) Planch

Mongalo

Raletsena

Munyai

2023

Life

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Cissus cornifolia (Baker) Planch is traditionally used in South African traditional medicine (SATM) to treat a variety of human infections. The antimicrobial activity of extracts from C. cornifolia was investigated in vitro against a plethora of pathogenic microorganisms using the microdilution assay. The acetone extract exhibited a notable minimum inhibitory concentration (MIC) value of 0.10 mg/mL against Mycoplasma hominis and a further MIC of 0.20 mg/mL against Candida parapsilosis, Streptococcus agalactiae, Pseudomonas aeruginosa, and Enterococcus faecalis. In the antiproliferative assays, both the ethyl acetate and methanol extracts exhibited a potent inhibition of the MCF-7-21 cell line. In the anti-inflammatory assays, both the ethyl acetate and methanol extracts exhibited IC50 values of 15.59 and 15.78 µg/mL against Cyclooxygenase-2 (COX-2), respectively. Methanol extract further exhibited potent dual inhibition of both COX-2 and 15-LOX enzymes, hence, recommended to curb both related cancers, particularly breast cancer and inflammation-borne diseases. In the comparative gas chromatography time-of-flight mass spectrometry (GC/TOF-MS), the acetone, ethyl acetate, and methanol extract contained significantly prevalent amounts of compound 2-(2’,4’,4’,6’,6’,8’,8’-Heptamethyltetrasiloxan-2’-yloxy)-2,4,4,6,6,8,8,10,10-nonamethylcyclopentasiloxane with % area ranging from 15.714 to 39.225. The findings in the current work validates the use of the plant species in SATM in the treatment of cancer-like infections, opportunistic infections associated with HIV-AIDS. Furthermore, the in vivo studies and the mechanisms of action still need to be explored.

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Section: Discussionmentioning

confidence: 99%

In Vitro Pharmacological Activity, and Comparison GC-ToF-MS Profiling of Extracts from Cissus cornifolia (Baker) Planch

Mongalo

Raletsena

Munyai

2023

Life

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“…71 However, they are susceptible to Zn-chelators such as carboxylic acid derivatives, e.g., succinic, salvianolic, picolinic, boronic, phosphonic and rosmarinic acids, and other metal ion sequesters including hesperidin, aspergillomarasmine and fisetin. 14,54 Diagnosis of metallo-β-lactamases…”

Section: Molecular Features Of B1 Subclass Of Metallo-β-lactamasesmentioning

confidence: 99%

“…The available antibiotics, specifically the most active β-lactamtypes, are subjected to deactivation by the notorious enzymes through the opening of their β-lactam rings and deacetylation of their corresponding complexes with the enzymes. 14,15,19,20 Progressively, scientists have devoted their efforts to curbing this global menace, and therefore a regular overview on this topic can aid in the required timely development of effective therapeutics. Among the recent reviews, Arshada and Hanif surveyed the chelating effects of some natural products, i.e., hydroxypyridone and hydroxythiopyridone derivatives, against several metalloenzymes implicated in cancer, diabetes and microbial diseases, including histone deacetylase (HDAC), tyrosinase and MBL.…”

Section: Introduction To Antimicrobial Resistance (Ar)mentioning

confidence: 99%

Small-molecule inhibitors of bacterial-producing metallo-β-lactamases: insights into their resistance mechanisms and biochemical analyses of their activities

2023

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“…The design of catalysts that rival the proficiency of metalloenzymes is an intense research topic of coordination chemistry. , Enzymes catalyze reactions in a dynamic manner, binding substrates at the labile coordination site and releasing products by interconverting the conformations on different time scales (Figure a). − Several crystallographic and time-resolved spectroscopic techniques have disclosed dynamic ligand exchanges in the vicinity of the catalytic site during photosynthesis, , nitrogen fixation, oxygen reduction, , DNA synthesis/cleavage, − etc . For example, in the Kok cycle of photosystem II (PSII), the substrate water would rearrange from Ca to pentacoordinate Mn in the S 2 → S 3 transition accompanied by the oxidation of Mn from III to IV, ,− during which the Ca-ligated D1-Glu189 residue moves away accordingly and makes space for the substrate water coordination (Figure b).…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Active Site with a Coordination-Adaptive Organosulfonate Ligand for Catalytic Water Oxidation at Neutral pH

et al. 2023

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Many enzymes use adaptive frameworks to preorganize substrates, accommodate various structural and electronic demands of intermediates, and accelerate related catalysis. Inspired by biological systems, a Ru-based molecular water oxidation catalyst containing a configurationally labile ligand [2,2′:6′,2″-terpyridine]-6,6″-disulfonate was designed to mimic enzymatic framework, in which the sulfonate coordination is highly flexible and functions as both an electron donor to stabilize highvalent Ru and a proton acceptor to accelerate water dissociation, thus boosting the catalytic water oxidation performance thermodynamically and kinetically. The combination of single-crystal Xray analysis, various temperature NMR, electrochemical techniques, and DFT calculations was utilized to investigate the fundamental role of the self-adaptive ligand, demonstrating that the ondemand configurational changes give rise to fast catalytic kinetics with a turnover frequency (TOF) over 2000 s −1 , which is compared to oxygen-evolving complex (OEC) in natural photosynthesis.

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Metalloenzyme mimicry and modulation strategies to conquer antimicrobial resistance: Metal-ligand coordination perspectives

Cited by 22 publications

References 102 publications

In Vitro Pharmacological Activity, and Comparison GC-ToF-MS Profiling of Extracts from Cissus cornifolia (Baker) Planch

In Vitro Pharmacological Activity, and Comparison GC-ToF-MS Profiling of Extracts from Cissus cornifolia (Baker) Planch

Small-molecule inhibitors of bacterial-producing metallo-β-lactamases: insights into their resistance mechanisms and biochemical analyses of their activities

Bioinspired Active Site with a Coordination-Adaptive Organosulfonate Ligand for Catalytic Water Oxidation at Neutral pH

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