2013
DOI: 10.1039/c3sc51731d
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Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?

Abstract: YesEnantiomers of a relatively rigid DNA-binding metallo-helix are shown to have comparable activity to that\ud of cisplatin against the cell lines MCF7 (human breast adenocarcinoma) and A2780 (human ovarian\ud carcinoma) but are ca five times more active against the cisplatin-resistant A2780cis. The cell-line\ud HCT116 p53+/+ (human colon carcinoma) is highly sensitive giving IC50 values in the nM range, far lower\ud than the cisplatin control. The hypothesis that the biological target of such metallohelices … Show more

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Cited by 62 publications
(59 citation statements)
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“…Recent studies on materials from Institut Lavoisier (MIL)-100(Cr) and MIL-100(Fe), however, suggest that MOFs can persist in biologically relevant environments and can act as vehicles for some anticancer and antiviral agents (8)(9)(10). These early findings have prompted further investigations into the biomedical applications of supramolecular coordination complexes (SCCs) (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). SCCs preserve the attractive properties of MOFs, such as building block modularity (22,23,25), yet afford an increased solubility in the biological milieu and lend themselves to small-molecule characterization techniques due to their well-defined structure.…”
mentioning
confidence: 99%
“…Recent studies on materials from Institut Lavoisier (MIL)-100(Cr) and MIL-100(Fe), however, suggest that MOFs can persist in biologically relevant environments and can act as vehicles for some anticancer and antiviral agents (8)(9)(10). These early findings have prompted further investigations into the biomedical applications of supramolecular coordination complexes (SCCs) (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). SCCs preserve the attractive properties of MOFs, such as building block modularity (22,23,25), yet afford an increased solubility in the biological milieu and lend themselves to small-molecule characterization techniques due to their well-defined structure.…”
mentioning
confidence: 99%
“…Herein, to achieve chiral recognition of Aβ, we strategically prepared thermodynamically stable single enantiomers of monometallic units [18][19][20] connected by organic linkers, [Fe2L 1 3]Cl4 (ΛFe,SC-[Fe2L 1 3]Cl4 and ΔFe,RC-[Fe2L 1 3]Cl4) and [Fe2L 2 3]Cl4 (ΛFe,RC-[Fe2L 2 3]Cl4 and ΔFe,SC-[Fe2L 2 3]Cl4), to enantioselectively target and inhibit Aβ aggregation. This highly adaptable self-assembly approach enables rapid preparation of ranges of waterstable, helicate-like compounds with high stereochemical purity.…”
Section: Introductionmentioning
confidence: 99%
“…In particular, distortions of the DNA structure induced by metalbased anticancer agents often correlate with anticancer activity [13,14,15]. Hence, it is of great importance to understand in detail the DNA binding properties of novel metal complexes and their possible relationship to cytotoxicity in tumor cells since this may provide grounds for establishing new structure-pharmacological activity relationships.…”
Section: Introductionmentioning
confidence: 99%