Metalloproteinase expression in venous aneurysms

Irwin, Chance; Synn, Alan Y.; Kraiss, Larry W.; Zhang, Qixu; Griffen, Moya M.; Hunter, Glenn C.

doi:10.1016/j.jvs.2008.06.056

Cited by 63 publications

(47 citation statements)

References 25 publications

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“…cough) weakness of venous wall [6][7][8][9] . Although some authors reported no evident pathologic changes 10 reports of others included a detailed microscopic description of the lesions called endophlebohypertrophy and endophlebosclerosis 8,9,[11][12][13] , which was also found in the our case 1. Some histologic features of these findings were described also in clearly congenital jugular venous aneurysm; it had been present at birth 14 .…”

Section: Literature Review and Discussionsupporting

confidence: 56%

“…Therefore it seems that venous aneurysms may also arise in congenitally predisposed persons as a consequence of aquired mechanisms 8 . At the molecular level, increased expression of some matrix metalloproteinases in the wall of venous aneurysms suggests a possible causal role in their pathogenesis 13 . Venous aneurysms occur equally between the sexes 5,8 or with a slight female predominance 15 .…”

Section: Literature Review and Discussionmentioning

confidence: 99%

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Lesser Saphenous Vein Aneurysm and Popliteal Vein Aneurysm: Report of Two Cases and Review of the Literature

Drác¹,

Utíkal²,

Köcher³

et al. 2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background: During the last ten years we diagnosed two cases of venous aneurysm. The purpose of this report was to point out a certain risk of the thrombembolism of superficial venous aneurysms and to review our experience in the management of superficial and deep venous aneurysms.Methods: The presentation and management of these lesions were reviewed and discussed together with other cases from available literature.Results: In the first case an aneurysm of lesser saphenous vein with a possible threat of thrombembolism was revealed and surgically solved with saphena resection. Ten years after the surgery she is still symptom free. In the second case a small fusiforme popliteal vein aneurysm without any evidence of mural thrombus was diagnosed. The patient was treated conservatively with regular venous duplex imaging follow up. Two years later the disease has been stable.Conclusions: Superficial venous aneurysms can have a certain risk of the thrombembolism. Since surgical therapy is very simple, it can be recommended in all cases. Nevertheless, trombembolism is more common in deep venous aneurysms, especially popliteal ones, in which surgical repair can be based on their pathological features and presentation or can be indicated in all cases.

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Section: Literature Review and Discussionsupporting

confidence: 56%

Section: Literature Review and Discussionmentioning

confidence: 99%

Lesser Saphenous Vein Aneurysm and Popliteal Vein Aneurysm: Report of Two Cases and Review of the Literature

Drác¹,

Utíkal²,

Köcher³

et al. 2009

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…Venous aneurysms of vessels not associated with chronic venous hypertension (primary or congenital) demonstrate thinning of the medial layer of the venous wall. 12 The etiology of venous aneurysmal dilatation secondary to chronic venous disease is the same as for varicosed segments; persistent venous hypertension and abnormal valve function. One theory portends a turbulent flow pat- tern associated with a dysfunctional valve.…”

Section: Discussionmentioning

confidence: 99%

Aneurysms of the superficial venous system: classification and treatment

Bush

2014

Veins and Lymphatics

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Superficial venous aneurysms are rarely described and they may remain indolent or become the source for pulmonary emboli. A system of classification and treatment protocol according to size and location is proposed.Three hundred thirty patients were evaluated for symptomatic venous disease (C2-C6) over a 2-year period. A proposed designation for venous aneurysm is described. Patients fulfilling this criterion are described in reference to site of involvement, histologic findings, and method of treatment. Five percent of patients met the criteria for venous aneurysm. Nine aneurysms of the greater saphenous vein were identified. Three aneurysms were proximal to the subterminal valve and the rest were distal.

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“…Venous aneurysms are divided into two as primary and secondary aneurysms [1]. Secondary ones are mainly due to trauma, infection, inflammation, venous valve insufficiency and arteriovenous malformations.…”

Section: Introductionmentioning

confidence: 99%

“…A clear aetiology has not been yet established. Recent literature states that structural changes take place in the vessel wall due to increased matrix metalloproteinases [1]. The most common location for a venous aneurysm is lower extremities with popliteal vein is the leading one.…”

Section: Introductionmentioning

confidence: 99%