Metalloproteinases, vascular endothelial growth factor, and angiopoietin 1 and 2 in eutopic and ectopic endometrium

Carlo, Costantino Di; Bonifacio, Marika; Tommaselli, Giovanni A.; Bifulco, Giuseppe; Guerra, Germano; Nappi, Carmine

doi:10.1016/j.fertnstert.2008.03.079

Cited by 86 publications

(73 citation statements)

References 26 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…20,[30][31][32] Importantly, VEGF-A concentration in the peritoneal fluid significantly correlates with the stage of endometriosis.…”

mentioning

confidence: 96%

“…[18][19][20] Peritoneal fluid from affected women exhibits elevated concentrations of diverse angiogenic growth factors and cytokines, and reduced amounts of antiangiogenic molecules. [21][22][23][24][25] Equally as in physiological and tumor angiogenesis, vascular endothelial growth factor A (VEGF-A) plays the role of the principal positive angiogenic regulator in endometriotic lesions.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Angiogenesis as a Therapeutic Target in Endometriosis

Djokovic

Calhaz‐Jorge

2014

Acta Med Port

View full text Add to dashboard Cite

RESUMOIntrodução: A angiogénese é um factor determinante no estabelecimento e desenvolvimento das lesões de endometriose. Material e Métodos:Foram revistos os artigos indexados na PubMed e incluídos os estudos mais relevantes, publicados até Janeiro de 2014, sobre a angiogénese nas lesões de endometriose e/ou estratégias anti-angiogénicas para o tratamento desta doença ginecológica.Resultados: O presente artigo fornece um resumo conciso dos mecanismos moleculares conhecidos que promovem a vascularização das lesões de endometriose, podendo servir como alvos terapêuticos potenciais. Apresenta-se também uma revisão sistemática dos agentes anti-angiogénicos, inclusivos e exclusivos, que já foram avaliados em culturas de células, modelos animais e/ou doentes com endometriose. Discussão e Conclusão: A integração das estratégias anti-angiogénicas na terapêutica multimodal de endometriose será condicionada pelos resultados de avaliações futuras da verdadeira eficácia desses tratamentos, do risco de desenvolvimento de resistência aos medicamentos e da incidência de efeitos colaterais inaceitáveis. Palavras-chave: Inibidores da Angiogénese/uso terapêutico; Endometriose/terapêutica. ABSTRACT Introduction:Angiogenesis is a key factor for the successful establishment and growth of endometriotic lesions. Material and Methods:We performed a literature search in PubMed and reviewed the most pertinent studies published until January 2014 and focused on the endometriosis-associated angiogenesis and/or anti-angiogenic strategies for the treatment of this gynecological disorder. Results:The present review provides a concise summary of the known molecular mechanisms that promote vascularization of endometriotic lesions and may serve as potential therapeutic targets. We also present a systematic overview of the inclusive and exclusive anti-angiogenic agents that have been already studied in cell cultures, animal models and/or endometriosis patients. Discussion and Conclusion:The integration of anti-angiogenic approaches in the multimodal management strategies for endometriosis patients will be conditioned by the outcomes of future assessments regarding the effectiveness of such treatments, the risk of drug resistance development and the incidence of unacceptable side effects.

show abstract

“…20,[30][31][32] Importantly, VEGF-A concentration in the peritoneal fluid significantly correlates with the stage of endometriosis.…”

mentioning

confidence: 96%

mentioning

confidence: 99%

Angiogenesis as a Therapeutic Target in Endometriosis

Djokovic

Calhaz‐Jorge

2014

Acta Med Port

View full text Add to dashboard Cite

show abstract

“…Previous studies have revealed the presence of elevated angiogenic factors in the peritoneal fluid, serum, and endometriotic tissues of women with endometriosis as compared to women without endometriosis (Di Carlo et al 2009). However, a few studies have examined the blood vessels present in the cyst wall tissues of patients with endometrioma.…”

Section: Discussionmentioning

confidence: 98%

“…Angiogenesis is known to play a major role in the growth and survival of endometriosis (Inan et al 2003;Di Carlo et al 2009;Laschke et al 2011;Li et al 2016); additionally, it might be enhanced by increased endothelial cell activation. Previous studies have revealed the presence of elevated angiogenic factors in the peritoneal fluid, serum, and endometriotic tissues of women with endometriosis as compared to women without endometriosis (Di Carlo et al 2009).…”

Section: Discussionmentioning

confidence: 99%

The Expression of Cyclophilin A in Ovarian Endometrioma: Its Correlation with Recurrence and Vascularity

Usta

Turan

Adalı

2017

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Endometriosis is defined as the presence of functional endometrial tissues outside of the uterine cavity. Ovarian endometrioma is the most common type of endometriosis. It is an estrogen-dependent inflammatory disease that frequently causes infertility and chronic pelvic pain. Cyclophilin A (CyPA) is secreted from various types of cells in response to inflammatory stimuli. Many previous studies have shown that the increased expression and/or heightened plasma levels of CyPA exacerbates inflammation. The aim of this study is to evaluate CyPA immunoreactivity in ovarian endometrioma cyst wall. In this cross-sectional study, CyPA immunoreactivity in endometrial tissue samples obtained from uterine cavity and in endometrioma cyst walls of 44 consecutive women with ovarian endometrioma were compared with control endometrial tissue samples obtained from uterine cavity of 40 women without endometrioma. All endometrioma samples were confirmed via histopathological examination. Finally, the relationship between CyPA immunoreactivity and the clinicopathological findings related to endometrioma were evaluated. The CyPA expression rates in glandular cells, stromal cells, and the capillary endothelium were significantly higher in endometrioma cyst walls of women with ovarian endometrioma than in the control endometrial tissue of women without endometrioma (p = 0.0002, p = 0.0417 and p = 0.0067, respectively). The correlation analysis demonstrated that glandular CyPA expression was correlated with endometrioma recurrence (p = 0.0267). However, stromal and vascular endothelial CyPA expression were correlated with dysmenorrhea recurrence (p = 0.0023 and p = 0.0003, respectively). In conclusion, the increased expression of CyPA in ectopic endometrial tissue is associated with endometrioma recurrences and vascularity.

show abstract

“…At the same time the amount of the MMP-13 in peritoneal fluid of patients was significantly decreased in comparison to that in healthy women (Laudanski et al, 2005). In eutopic endometrium of women with endometriosis the elevation of the expression of MMP-1, MMP-2, MMP-3, MMP-9 was found (Di Carlo et al, 2009;Shaco-Levy et al, 2008). Diminishment of the expression of MMPs inhibitors TIMP-1 and TIMP-2 in endometrium of endometriosis patients was also noted (Colett et al, 2004;Uzan et al, 2004).…”

Section: Changes Of the Invasiveness Of Endometrium In Endometriosismentioning

confidence: 97%