Metalloradical approach for concurrent control in intermolecular radical allylic C−H amination

Recent Advances in Theoretical Studies on Cu-Mediated Bond Formation Mechanisms Involving Radicals

“…This process affords the new covalent bond between “radical” and “ligand”, while Cu­(II) accepts one electron and is reduced to Cu­(I). The radical substitution mechanism has been recently validated to exist in a number of transition metal radical transformation systems. − This section will cover the reported copper-mediated radical transformations via the radical substitution mechanism.…”

NHC-catalyzed enantioselective radical reactions of enal and pyridinium salt: mechanism and origin of regio- and stereoselectivities

“…In recent years, a variety of effective radical generation strategies and highly selective radical reactions have been developed using photochemistry, [12][13][14] electrochemistry, [15][16][17] organic superelectron donors, 18,19 and transition metal catalysis. 20,21 Notably, a N-heterocyclic carbene (NHC) organocatalyst [22][23][24] contains a divalent carbene carbon that can provide a lone electron pair and form a stable conjugate radical intermediate with a carbonyl compound substrate, making it ideal for stereoselective radical reactions. [25][26][27] However, due to the high reactivity and instability of radical species, understanding the origin of regio-and stereoselectivities of the NHC-mediated radical reactions remains a significant challenge.…”

Merging of Light/Dark Palladium Catalytic Cycles Enables Multicomponent Tandem Alkyl Heck/Tsuji–Trost Homologative Amination Reaction toward Allylic Amines

“…Accordingly, the development of general and efficient methods toward allylic amines from various precursors has been extensively explored . Arguably, the Pd-catalyzed Tsuji–Trost reaction is one of the most powerful modern approaches toward allylic amines, which allows for mild and general construction of allylic amines with high degrees of regio- and stereocontrol (Scheme b I ) .…”