Metallosis and cobalt – chrome intoxication after hip resurfacing arthroplasty

Czekaj, Jaroslaw; Ehlinger, Matthieu; Rahmé, Michel; Bonnomet, F.

doi:10.1016/j.jos.2015.06.001

Cited by 11 publications

(4 citation statements)

References 22 publications

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“…Una investigación realizada en Grecia en el 2014, sin tener en cuenta un ambiente de curtiembre arrojó cifras de Cr hexavalente dentro de límites normales; del análisis de estas investigaciones se desglosa que existe una relación indiscutible entre el riesgo de contaminación de las aguas y la cercanía de las industrias que utilizan este elemento químico [20]. Por otro lado, también se evidencian intoxicaciones por Cr, en personas que se han sometido a artroplastia de revestimiento cadera, demostrando una vez más la toxicidad de este material en dosis elevadas [21].…”

Section: Resultados Y Discusiónunclassified

Hexavalent Chromium in Waters for Human Consumption and Irrigation in the Guano Canton

Castillo-López

Salas-Cisneros

Logroño-Veloz

et al. 2021

espoch

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Introduction: Considering the geographical location and industrial activities of the county Guano, which lies on an aquifer that supply water for both consumption and crop irrigation, it is necessary to examine the levels of chromium (Cr) in its watershed and tributaries. Objective: To evaluate the amount of Cr existing in the surface waters of the Guano river basin and aquifer. Methods: Several samples of the river and aquifer were taken and the amount of Cr present was measured. Using Z-test, Cr levels found in the water were compared with those recommended as normal by the World Health Organization (WHO), national standards of the Texto Unificado de Legislación Secundaria de Medio Ambiente (TULSMA) and the Servicio Ecuatoriano de Normalización 1108 ( INEN 1108). Results: Relatively high Cr values were found when compared with those established by the WHO. However, they were normal when compared with TULSMA and INEN 1108. Conclusion: The levels of Cr found in the Guano river and the aquifer were higher than those recommended by the WHO. It is recommended to replicate our findings in order to corroborate the results and to take appropriate measures in order to reduce water contamination. Keywords: chromium, water, Guano, Ecuador. Resumen Introducción: Considerando la ubicación geográfica y actividades industriales del cantón Guano el cual yace sobre un acuífero que sustenta las necesidades de agua tanto para consumo y riego de la población es necesario examinar los niveles de Cromo (Cr) en su vertiente como sus afluentes. Objetivo: Evaluar la cantidad de Cr existente en las aguas superficiales de la cuenca del río Guano y en pequeños ojos de agua provenientes del acuífero. Métodos: Se tomó varias muestras de agua del río y ojos de agua y se midió la cantidad de Cr presente. Por medio de la prueba Z se comparó los niveles de Cr con los recomendados como normales por la Organización Mundial de la Salud (OMS), normas nacionales del Texto Unificado de Legislación Secundaria de Medio Ambiente (TULSMA) y Servicio Ecuatoriano de Normalización 1108 (INEN 1108). Resultados: Se encontró valores relativamente altos de Cr al compararlos con los establecidos por la OMS. Sin embargo, estos se encontraron dentro de rangos normales al compararlos con TULSMA e INEN 1108. Conclusiones: Los niveles de Cr encontrados en el río Guano y ojos de agua del acuífero son superiores a los recomendados por la OMS. Se recomienda replicar los hallazgos para corroborar los resultados y tomar las medidas adecuadas para reducir la contaminación del agua. Palabras clave: cromo, agua, Guano, Ecuador.

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Section: Resultados Y Discusiónunclassified

Hexavalent Chromium in Waters for Human Consumption and Irrigation in the Guano Canton

Castillo-López

Salas-Cisneros

Logroño-Veloz

et al. 2021

espoch

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“…Metallosis is defined as aseptic fibrosis, local necrosis, or loosening of a device secondary to metallic corrosion and release of wear debris [5]. It can be related to many different types of metal implants, such as titanium [5,6], cobalt/chromium [6][7][8] or different joint replacements such as hip, knee and shoulder [6,[9][10][11][12].…”

Section: Terminologymentioning

confidence: 99%

Metallosis Die Hard

Xia¹

2017

SM Musculoskelet Disord

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Metallosis is an aseptic fibrosis, local necrosis, inflammation, or loosening of an implant device secondary to metallic corrosion and release of wear debris. The condition has been highlighted recent years due to the clinical complications caused by metal-on-metal (MoM) hip replacement. Although some major types of MoM hip prostheses have been recalled from the market, metallosis is far from over as not only there are still a million implanted MoM hip prosthetic cases worldwide, but also it has been found in non-MoM hip prostheses and other metal implants. This mini review aims to provide recent findings of implants related metallosisin skeletal tissue.

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“…Although polyneuropathy from cobalt-chromium intoxication is one of the worstcase scenarios, chronic infiltration of metal debris can lead to chronic local inflammatory changes as well as broad-spectrum systemic clinical reactions [9]. In such a context, the musculoskeletal tissue may be drastically affected by an aberrant concentration of metal ions and experience muscle atrophy and increased fat infiltration [4].…”

Section: Introductionmentioning

confidence: 99%

Metallosis after Hip Arthroplasty Damages Skeletal Muscle: A Case Report

Bonanni,

Abbondante,

Cariati

et al. 2023

Geriatrics

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Good musculoskeletal quality dramatically influences the outcome of an arthroplasty operation in geriatric patients, as well as is a key element for optimal osseointegration. In this context, metallosis is a complication associated with the type of prosthesis used, as implants with a chromium–cobalt interface are known to alter the bone microarchitecture and reduce the ratio of muscle to fat, resulting in lipid accumulation. Therefore, the aim of our study was to investigate possible muscle changes by histological, morphometric, and immunohistochemical analyses in a patient undergoing hip replacement revision with elevated blood and urinary concentrations of chromium and cobalt. Interestingly, the muscle tissue showed significant structural changes and a massive infiltration of adipose tissue between muscle fibers in association with an altered expression pattern of important biomarkers of musculoskeletal health and oxidative stress, such as myostatin and NADPH Oxidase 4. Overall, our results confirm the very serious impact of metallosis on musculoskeletal health, suggesting the need for further studies to adopt a diagnostic approach to identify the cause of metallosis early and eliminate it as part of the prosthesis revision surgery.

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Metallosis and cobalt – chrome intoxication after hip resurfacing arthroplasty

Cited by 11 publications

References 22 publications

Hexavalent Chromium in Waters for Human Consumption and Irrigation in the Guano Canton

Hexavalent Chromium in Waters for Human Consumption and Irrigation in the Guano Canton

Metallosis Die Hard

Metallosis after Hip Arthroplasty Damages Skeletal Muscle: A Case Report

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