Metallosurfactants as Carbon Monoxide‐Releasing Molecules

Properties and Cellular Uptake of Photo-Triggered Mixed Metallosurfactant Vesicles Intended for Controlled Co Delivery in Gas Therapy

“…Soybean phosphatidylcholine (SPC; 97%; MW 775 Da) was obtained from Avanti Polar Lipids. The metallosurfactant with CO releasing properties was obtained according to the synthesis described by Parera et al 21 Briefly, the ligand with the structure Ph 2 P(CH 2 ) 10 SO 3 Na substitutes piperidine (pip) in the complex cis-[Mo(CO) 4 (pip) 2 ] and the reaction leads to a complex that bears four CO groups that are prone to be released as CO gas, for example, under light irradiation [23]. This molecule (TCOL10) is a metallosurfactant composed of a hydrophobic domain (the Mo complex and the two hydrocarbon chains) and two polar headgrups (sulfonates) located at the end of these chains.…”