Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease

Brewster, James T.; Harvey, P. K.; Zafar, Hadiqa; Reuther, James F.; Dell’Acqua, Simone; Johnson, Rachel M.; Root, Harrison D.; Metola, Pedro; Jasanoff, Alan; Casella, Luigi; Sessler, Jonathan L.

doi:10.1016/j.chempr.2019.12.016

Cited by 24 publications

(17 citation statements)

References 68 publications

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“…These cells were purchased from the American Type Culture Collection and cultivated under acceptable conditions; temperature and CO 2 were set at 37 C and 5%, respectively. MTT assay, one of the most frequently used methods, [61][62][63] was introduced to evaluate cell viability and cytotoxicity induced by different treatments.…”

Section: Article Cell Culture and Cytotoxicity Assaymentioning

confidence: 99%

“…As previously reported, isobologram analysis was used to evaluate the synergistic effect between GTe-RGD and X-ray. Data points that fall on the straight line below indicate the synergistic effect of X-ray and GTe-RGD 63,64 but if the point lies above or below the straight line, this represents antagonism or synergism effect, respectively.…”

Section: Isobologram Analysismentioning

confidence: 99%

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Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy

Huang

Ouyang

et al. 2020

Matter

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Section: Article Cell Culture and Cytotoxicity Assaymentioning

confidence: 99%

Section: Isobologram Analysismentioning

confidence: 99%

Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy

Huang

Ouyang

et al. 2020

Matter

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“…Indeed, to date, a huge diversity of manganese complexes has been reported for their ability to react catalytically with superoxide. They involved ligands such as salen derivatives [11][12][13], cyclic polyamine [14][15][16][17][18][19], tri-or dipodal nitrogen-centered ligands [20][21][22][23][24], 1,2-ethanediaminecentered ligands [25][26][27], desferrioxamine derivatives [15,28,29], polyaminocarboxylato- [30][31][32] or polycarboxylato ligands [33], peptides [34][35][36], porphyrins [37][38][39][40][41][42], phthalocyanines [43], texaphyrins [44,45], corroles [46][47][48] or biliverdin and its derivatives [49]. Some of these complexes have thus far been assayed on cellular [49][50][51][52][53][54]…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the compounds commonly known as superoxide dismutase and catalase mimics in cellular models

Vincent

Thauvin

Quévrain

et al. 2021

Journal of Inorganic Biochemistry

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Oxidative stress that results from an imbalance between the concentrations of reactive species (RS) and antioxidant defenses is associated with many pathologies. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase are among the key enzymes that maintain the low nanomolar physiological concentrations of superoxide and hydrogen peroxide. The increase in the levels of these species and their progeny could have deleterious effects. In this context, chemists have developed SOD and CAT mimics to supplement them when cells are overwhelmed with oxidative stress. However, the beneficial activity of such molecules in cells depends not only on their intrinsic catalytic activities but also on their stability in biological context, their cell penetration and their cellular localization. We have employed cellular assays to characterize several compounds that possess SOD and CAT activities and have been frequently used in cellular and animal models. We used cellular assays that address SOD and CAT activities of the compounds. Finally, we determined the effect of compounds on the suppression of the inflammation in HT29-MD2 cells challenged by lipopolysaccharide. When the assay requires penetration inside cells, the SOD mimics Mn(III) mesotetrakis(N-(2′-nbutoxyethyl)pyridinium-2-yl)porphyrin (MnTnBuOE-2-PyP 5+ ) and Mn(II) dichloro [(4aR,13aR,17aR,21aR)-

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“…In recent years, the prevalence of neurodegenerative disorders is increasing [1][2][3][4]. Dementias are responsible for the greatest burden of neurodegenerative diseases.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Diversified Hamigeran B Analogs as Neuroinflammatory Inhibitors and Neurite Outgrowth Stimulators

Han

et al. 2020

Marine Drugs

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We describe the efficient synthesis of a series of new simplified hamigeran B and 1-hydroxy-9-epi-hamigeran B norditerpenoid analogs (23 new members in all), structurally related to cyathane diterpenoid scaffold, and their anti-neuroinflammatory and neurite outgrowth-stimulating (neurotrophic) activity. Compounds 9a, 9h, 9o, and 9q exhibited moderate nerve growth factor (NGF)-mediated neurite-outgrowth promoting effects in PC-12 cells at the concentration of 20 μm. Compounds 9b, 9c, 9o, 9q, and 9t showed significant nitric oxide (NO) production inhibition in lipopolysaccharide (LPS)-activated BV-2 microglial cells, of which 9c and 9q were the most potent inhibitors, with IC50 values of 5.85 and 6.31 μm, respectively. Two derivatives 9q and 9o as bifunctional agents displayed good activities as NO production inhibitors and neurite outgrowth-inducers. Cytotoxicity experiments, H2O2-induced oxidative injury assay, and ELISA reaction speculated that compounds may inhibit the TNF-α pathway to achieve anti-inflammatory effects on nerve cells. Moreover, molecular docking studies provided a better understanding of the key structural features affecting the anti-neuroinflammatory activity and displayed significant binding interactions of some derivatives (like 9c, 9q) with the active site of iNOS protein. The structure-activity relationships (SARs) were also discussed. These results demonstrated that this structural class compounds offered an opportunity for the development of a new class of NO inhibitors and NGF-like promotors.

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Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer’s Disease

Cited by 24 publications

References 68 publications

Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy

Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy

Evaluation of the compounds commonly known as superoxide dismutase and catalase mimics in cellular models

Synthesis and Biological Evaluation of Diversified Hamigeran B Analogs as Neuroinflammatory Inhibitors and Neurite Outgrowth Stimulators

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