2021
DOI: 10.1101/2021.07.28.454033
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Metallothionein 3-zinc axis suppresses caspase-11 inflammasome activation and impairs antibacterial immunity

Abstract: Non-canonical inflammasome activation by mouse caspase-11 (or human CASPASE-4/5) is crucial for the clearance of certain gram-negative bacterial infections, but can lead to severe inflammatory damage. Factors that promote non-canonical inflammasome activation are well recognized, but less is known about the mechanisms underlying its negative regulation. Herein, we identify that the caspase-11 inflammasome in mouse and human macrophages (Mϕ) is negatively controlled by the zinc (Zn2+) regulating protein, metall… Show more

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Cited by 1 publication
(3 citation statements)
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“…Zinc, one of the micronutrients, is important for the modulatory effect in sepsis inflammation. As mentioned above, Zinc also acts the indirect inhibitor on TRIF-IRF3 activation signals (54). Metabolic state is also strongly related to the inflammasome signaling and lethality.…”
Section: ) Coupling To Immunometabolic Paralysis As Well As Activatio...mentioning
confidence: 96%
See 2 more Smart Citations
“…Zinc, one of the micronutrients, is important for the modulatory effect in sepsis inflammation. As mentioned above, Zinc also acts the indirect inhibitor on TRIF-IRF3 activation signals (54). Metabolic state is also strongly related to the inflammasome signaling and lethality.…”
Section: ) Coupling To Immunometabolic Paralysis As Well As Activatio...mentioning
confidence: 96%
“…Furthermore, caspase-11 activation can also be affected by other proteins (54). The caspase-11 inflammasome in macrophages is negatively regulated by the zinc (Zn2+)-regulating protein, metallothionein 3 (MT3).…”
Section: Intracellular Molecules and Irf3 Activationmentioning
confidence: 99%
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