Metallothionein in liver of eels Anguilla anguilla from the Thames Estuary: an indicator of environmental quality?

Langston, W.J.; Chesman, BS; Burt, G. R.; Pope, Nick; McEvoy, J.

doi:10.1016/s0141-1136(01)00113-1

Cited by 135 publications

(59 citation statements)

References 20 publications

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“…In H. mylodon, liver was more sensitive to metal ions than kidney and gill (Cho et al, 2008), and the increase of hepatic metallothionein mRNA was dose-dependent in other studies (Langston et al, 2002;Lin et al, 2004;Cho et al, 2005). Induction of hepatic MTs by Cd was time-dependent but transient.…”

Section: Hepatopancreasmentioning

confidence: 67%

“…period and then decrease down in longer exposures has been found before, and it might be due to the "indication of saturation" or "acclimation process" of the organisms to tissue loads resulted from accumulated metals (Langston et al, 2002;Basha and Rani, 2003;Cho et al, 2006).…”

Section: Hepatopancreasmentioning

confidence: 74%

“…Owing to its highly inducible expression during exposures to various heavy metals, MTs have been paid much attention as a potential biomarker to monitor the heavy metal pollution of aquatic ecosystem, a major receptor of pollutants especially with relatively high amount of heavy metals (Langston et al, 2002;Tom et al, 2004;Cho et al, 2005). Nevertheless, the application of MTs to biomarker assay needs large evaluation of a number of abiotic and biotic factors such as salinity, pH, temperature, seasonality, fish age, sex, and reproductive cycle that may affect the expression of MTs Marijić and Raspor, 2006).…”

Section: Application Of Mts As a Biomarker For Evaluating The Aquaticmentioning

confidence: 99%

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Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Weichao

Mao

et al. 2014

Front. Mar. Sci.

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The documents on Metallothioneins (MTs) in aquatic creatures, especially focusing on their function as biomarkers in environmental monitoring programmes, are vast and increasing. There are, however, few papers to summary the physiological role of MTs in aquatic organisms especially on development. The multifaceted roles of MTs include involvement in homeostasis, protection against heavy metals and oxidant damages, and metabolic regulation, sequestration and/or redox control. In this paper, we have collected published information on MTs in aquatic organisms-pisces, amphibians, mammals, etc., and analyzed their function in these aquatic animals. MTs have four main functions in aquatic vertebrate. They are respectively bioaccumulation of toxic metals and detoxification, homeostatic regulation of metals, protection against oxidative stress and neuroprotective mechanism. MTs separate in different tissues and they have various distributions in different tissues of aquatic vertebrate, including liver, gills, kidney, testes, and brain. MTs can be induced by a variety of environmental and physiological factors, among which, heavy metals are the main kind of MTs inducers in aquatic vertebrate. Here we pay more attention on the essential metals copper (Cu) and zinc (Zn) and the non-essential metals cadmium (Cd), silver (Ag), lead (Pb), and mercury (Hg).

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Section: Hepatopancreasmentioning

confidence: 67%

Section: Hepatopancreasmentioning

confidence: 74%

Section: Application Of Mts As a Biomarker For Evaluating The Aquaticmentioning

confidence: 99%

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Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Weichao

Mao

et al. 2014

Front. Mar. Sci.

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“…to detoxify the animal (Langston et al, 2002). In blood plasma, Zn is bound to and transported by albumin (60%, low-affinity) and transferrin (10%) (Whitney and Rolfes, 2010).…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

EJERM

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An experiment was carried out to determine the ability of Pteridium aquilinum to accumulate zinc from solutions containing 10 mg/l zinc and 10mg/l of different inorganic and organic manures and to assess the effect of zinc on Clarias gariepinus. A 96-hour bioassay was carried out using Clarias gariepinus juveniles to determine the effect of its exposure on haematology and histology. The water and P.aquilinum were also analysed for zinc and other parameters. Variations were observed in haematological parameters such as Red blood cell, Packed cell volume, White blood cell, Haemoglobin and enzymes (Serum Glutamic -Oxaloacetic Transaminase, SGOT and Serum Glutamic -Pyruvic Transaminase, SGPT),while platelet and total protein showed no significant difference. Damage observed in organs included necrosis, cell individualization and disorganization and congestion.

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“…This is suitable for the role of MT gene induction regarding zinc homeostasis rather than to metal detoxification. Metallothionein is expected to be induced under conditions of elevated metal concentrations, allowing more binding sites to sequester the metal ions and preventing potential adverse effects (Langston et al, 2002). Some studies in a variety of fish such as killifish (Van Cleef-Toedt et al, 2001), silver barb (Wangsongsak et al, 2007) and grass carp (Tan et al, 2016) showed the elevation of MT expression level after being exposed to Cd.…”

Section: Discussionmentioning

confidence: 99%

Research Article Cadmium accumulation and metallothionein gene expression in the liver of swamp eel (Monopterus albus) collected from the Mae Sot District, Tak Province, Thailand.

Wahid¹,

Prasarnpun²,

Yimtragool³

2017

Genet. Mol. Res.

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ABSTRACT. Cadmium (Cd) is produced mainly as a by-product of zinc mining. In Thailand, the largest zinc mine is located in the Mae Sot district, Tak Province. Samples of Monopterus albus were collected from paddy fields in 4 sites, three downstream and one upstream from the zinc mine. The upstream site was considered to be uncontaminated while the three downstream sites were considered to be contaminated with Cd. Studies on the accumulation level of cadmium were conducted on the liver of the fish using the atomic absorption spectrophotometer technique. The metallothionein (MT) gene expression level in the liver, as a potential biomarker for long-term Cd exposure in their natural habitat, was also assessed. The level of hepatic MT gene expression was performed by quantitative real-time PCR. The result showed that Cd accumulation in the liver was much higher in swamp eels collected from the downstream sites when compared to those collected from the upstream site. The hepatic MT level in the upstream site was 0.75-fold, 2 M. Wahid et al. Genetics and Molecular Research 16 (3): gmr16039748 while the other three downstream sites were 0.36-, 4.44-and 0.94-fold. There is no parallel correlation between hepatic cadmium levels and hepatic MT gene expression. This study then suggests that MT gene expression biomarkers might be not suitable for swamp eels with prolonged exposure to Cd.

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Metallothionein in liver of eels Anguilla anguilla from the Thames Estuary: an indicator of environmental quality?

Cited by 135 publications

References 20 publications

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Characteristics, functions, and applications of metallothionein in aquatic vertebrates

Untitled

Research Article Cadmium accumulation and metallothionein gene expression in the liver of swamp eel (Monopterus albus) collected from the Mae Sot District, Tak Province, Thailand.

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