Metallothionein induction and bioaccumulation kinetics of Cd and Ag in the marine fish Terapon jarbua challenged with dietary or waterborne Ag and Cu

Long, Aimin; Wang, Wen‐Xiong

doi:10.3354/meps291215

Cited by 21 publications

(11 citation statements)

References 44 publications

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“…The present results concerning dissolved metal uptake following metal pre‐exposure were consistent with those of a few recent studies [10,11]; however, these previous studies only examined metal uptake at one fixed, low concentration. Our results revealed that the influence of Cd pre‐exposure on Cd uptake rates was greater at a low ambient Cd concentration than at a high concentration.…”

Section: Discussionsupporting

confidence: 92%

“…Glover et al [9] determined the intestinal Zn uptake pattern in the gulf toadfish using in situ cannulation and concluded that the uptake was a biphasic pattern over a limited range of concentrations. A few recent studies also quantified metal uptake in marine fish from the dissolved phase at low ambient concentrations [10–12], but the relationship between metal influx and ambient bioavailable metal concentration remains less well explored. It remains to be determined whether marine fish have two transport systems for metals, similar to the systems observed in freshwater fish.…”

Section: Introductionmentioning

confidence: 99%

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Alteration of dissolved cadmium and zinc uptake kinetics by metal pre‐exposure in the black sea bream (Acanthopagrus schlegeli)

Zhang

Wang

2006

Enviro Toxic and Chemistry

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We first examined the uptake kinetics of Cd and Zn in the juvenile marine black sea bream (Acanthopagrus schlegeli) over a wide range of ambient Cd and Zn concentrations, and the relationships with metal accumulation (uptake rate and amount of nonexchangeable surface binding) were established for different fish tissues. Both Cd and Zn accumulation in the body increased linearly with exposure time after the initial metal surface binding. The dissolved Cd and Zn uptake rate constants were 2.64 and 6.50 L/kg/d, respectively, and the kinetics followed a first-order process. No evidence of biphasic transport was found, in contrast to the situation in freshwater fish. Viscera were the most important sites of metal uptake, and gills were the second most important sites. The black sea breams were then acclimated at different Cd or Zn concentrations from either waterborne or dietary source for one week, and the alteration of metal uptake kinetics or subcellular distribution and metallothionein (MT) induction were further quantified. The Cd body burden was enhanced up to 8.6- and 49-fold after waterborne and dietary Cd pre-exposure, respectively. Cadmium pre-exposure also altered the tissue-specific subcellular Cd distribution and significantly elevated tissue MT levels. In contrast, the black sea breams were able to regulate Zn accumulation, and waterborne or dietary Zn pre-exposure had only weak influences on Zn body burden and redistribution. Both Cd and Zn pre-exposures enhanced the metal uptake rate constants, whereas the nonexchangeable surface bindings were less impacted by these pre-exposures. We demonstrated a positive relationship between the Cd uptake rate and Cd or MT concentration in the fish. Pre-exposure to metals may substantially modify the kinetics of metal uptake.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Alteration of dissolved cadmium and zinc uptake kinetics by metal pre‐exposure in the black sea bream (Acanthopagrus schlegeli)

Zhang

Wang

2006

Enviro Toxic and Chemistry

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“…For example, MTLP-bound Cd in the scallops containing the largest amounts of MTLPs increased by 1.6-fold, whereas that in the control did not significantly change over the depuration period. Similarly, in the marine fish Terapon jarbua, Long and Wang [48] also found a negative correlation between Cd efflux rate constant and body-induced MTLP concentration. Additionally, intracellular organelles also may control Cd elimination in the scallops, because the fraction could remobilize and sequester cellular Cd from other subcellular pools during the metal elimination period.…”

Section: Role Of Mtlps In CD Eliminationmentioning

confidence: 82%

Differential roles of metallothionein‐like proteins in cadmium uptake and elimination by the scallop Chlamys nobilis

Liu

Wang

2011

Enviro Toxic and Chemistry

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Metallothionein-like proteins (MTLPs) are important inducible ligands for Cd detoxification, but whether MTLPs are involved in Cd bioaccumulation remains unclear. The present study investigated the potential interrelationships between MTLP turnover and Cd biokinetics in the scallop Chlamys nobilis with or without dissolved Cd pre-exposure. After Cd pre-exposure, increased synthesis rate and standing stock concentration of MTLPs as well as increased dissolved Cd uptake rate, were found in C. nobilis. However, the level of newly sequestrated Cd by MTLPs in the pre-exposed scallops was similar to that of the controls, indicating that MTLPs had no effect on Cd uptake from the dissolved phase. Instead, Cd uptake rate was positively related to the Cd binding rate of cellular debris and organelles. In addition, no significant difference was observed in the Cd dietary assimilation efficiency of the scallops, showing that MTLPs played a minimal role in Cd uptake from the dietary phase. Conversely, the Cd efflux rate constant decreased by 68 to 75% in the pre-exposed scallops in comparison with that in the control. Correspondingly, progressive elevations of MTLP-bound Cd and standing stock MTLP concentration were observed in the pre-exposed individuals during the Cd elimination period. In the pre-exposed scallops, the faster de novo MTLP synthesis could remobilize and recycle more Cd from other intracellular pools, effectively reducing the Cd elimination rate. The present study thus showed the differential roles of MTLPs in Cd uptake and elimination in the bivalves.

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“…Copper may become toxic and can be bound to MT for detoxification [90]. Long and Wang [91] have reported an increase of MT in all tissues and muscle of marine fish Terapon jarbua with increasing waterborne or dietary Cu concentration. They showed that the positive correlation between MT and Cu concentration in muscle implied that the accumulated Cu was sequestered by MT.…”

Section: Relationships Between Mt Levels and Heavy Metals Concentratimentioning

confidence: 99%

Evaluation of metallothionein content in giant mudskipper Periophthalmodon schlosseri collected from west coast of Peninsular Malaysia to assess environmental metal pollution

Buhari¹,

Ismail²

2017

JCLM

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Metallothionein induction and bioaccumulation kinetics of Cd and Ag in the marine fish Terapon jarbua challenged with dietary or waterborne Ag and Cu

Cited by 21 publications

References 44 publications

Alteration of dissolved cadmium and zinc uptake kinetics by metal pre‐exposure in the black sea bream (Acanthopagrus schlegeli)

Alteration of dissolved cadmium and zinc uptake kinetics by metal pre‐exposure in the black sea bream (Acanthopagrus schlegeli)

Differential roles of metallothionein‐like proteins in cadmium uptake and elimination by the scallop Chlamys nobilis

Evaluation of metallothionein content in giant mudskipper Periophthalmodon schlosseri collected from west coast of Peninsular Malaysia to assess environmental metal pollution

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