“…Bio-inert materials, most commonly based on Ti, Co, and steel, are critical for many load-bearing functions, where their resistance to corrosion provides excellent long-term stability and reliable mechanical strength, with minimal long-term toxicity to the host locally or on systemic level [ 16 , 17 ]. These materials have excellent tensile strength, fracture toughness and fatigue stress [ 18 , 19 ], and over the years, they have found applications in orthopaedics as artificial joints, plates and screws, orthodontics as braces and dental implants, cardiovascular and neurosurgical devices such as components of artificial hearts, staples, stents and wires. Among bio-inert materials, titanium is often the material of choice due to a favourable combination of biocompatibility, corrosion resistance, strength and elastic modulus, and relatively low weight and density when compared to conventional steel and Co-Cr alloys [ 20 ].…”