Metalworking fluids and cancer mortality in a US autoworker cohort (1941–2015)

Costello, Sadie; Chen, Kevin; Picciotto, Sally; Lutzker, Liza; Eisen, Ellen

doi:10.5271/sjweh.3898

Cited by 13 publications

(5 citation statements)

References 27 publications

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“…The UAW-GM cohort study has been described in detail elsewhere ( Costello et al, 2020 ; E. A. Eisen et al, 1992 ). Briefly, the cohort consists of 46,294 hourly workers, at three automobile manufacturing plants in Michigan, with at least three years of employment.…”

Section: Methodsmentioning

confidence: 99%

Racial disparities in alcohol-related liver disease mortality in a 75 year follow-up study of Michigan autoworkers

Allouch

Chen

Lutzker

et al. 2021

SSM - Population Health

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Background Suicide, drug overdose, and alcohol-related liver disease (ALD) mortality have been rising in the United States. While suicide and overdose have received a great deal of attention, far less public health concern has focused on chronic ALD. To address this gap, we examine ALD mortality rates, by race, in a cohort of autoworkers to describe trends over the past 75 years, from the peak in automobile manufacturing employment through its decline. Methods Based on the United Autoworkers-General Motors (UAW-GM) cohort we estimated temporal trends in age-adjusted ALD mortality rates from 1941 through 2015 at three automobile manufacturing plants in Michigan. We compared these rates to county, state, and U.S. rates, directly standardized to the 2000 U.S. census, to assess the roles of race and employment on ALD mortality. Results The overall age-adjusted ALD mortality rate among 41,097 male autoworkers peaked at 46.1 per 100,000 in the 1970s, followed by a gradual decline and a recent rise. Rates were slightly higher for black than white men until early 2000s, when rates increased only for white men. ALD mortality rates in the study cohort tracked national, state, and county rates for white men until the most recent time period, but were lower throughout the study period for black men, especially in the 1970s and 1980s. Conclusions Employment in automobile manufacturing may have offered some protection against death from ALD for black men, and loss of those manufacturing jobs may have impacted white men without a college degree more in recent decades.

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Section: Methodsmentioning

confidence: 99%

Racial disparities in alcohol-related liver disease mortality in a 75 year follow-up study of Michigan autoworkers

Allouch

Chen

Lutzker

et al. 2021

SSM - Population Health

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“…Machine operators in Ibadan have seven (7) ways of disposing of spent cutting fluids as shown in Figure 4. This includes pouring in the river, ground, storm drainage (gutter), in a dung hole, highway, environmental agency, and bushes.…”

Section: Mode Of Disposal Of Spent Cutting Fluids In Ibadanmentioning

confidence: 99%

“…Furthermore, the major difficulty of cutting fluids is particularly connected to their improper disposal, which results in surface water and groundwater contamination, as a result, agricultural product, and food contamination [6]. Additionally, cutting fluid particles that linger in the air for a long time can have an impact on workers who are not in contact with the cutting fluids directly [7,8]. Laws to control the use of lubricants in nations have been passed because of public knowledge of these dangerous consequences of employing cutting fluid.…”

Section: Introductionmentioning

confidence: 99%

Cutting Fluids Usage and Impacts in Metal Workshops in Ibadan, Southwestern Nigeria

Kazeem¹,

Fadare²,

Adebayo³

et al. 2023

IJSDP

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This paper presents a report on cutting fluids utilization and its impacts on workers in machining workshops in Ibadan, Nigeria. The major users of cutting fluids and their workshops were identified. It was found that there are 103 operating metal workshops in Ibadan and these workshops are located within seven local government areas of the city. Out of the total number, 85 are in fabrication, 39 are in crankshaft operations and 32 are engaged in block boring operations. The type and consumption of cutting fluids, coolant delivery techniques, length of use before disposal, disposal methods, and monitoring maintenance were studied. The results indicated that the most used cutting fluid is soluble oil with average total consumption of 402 litres monthly. The pouring of spent cutting fluids on the ground is the most adopted disposal method. Research on occupation exposures to cutting fluids has suggested that machine operators in metal cutting are at high risk of developing cancer, allergenic disorders, and lung diseases. Results obtained also showed that less than 22% of machine operators were aware of occupational hazards. Few of the operators (23%) wore safety devices/clothing, and health and safety standards were neither practiced nor enforced.

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“…asbestos Italy [32] Lumber, wood products, printing and allied industries, petroleum and coal products, fabricated metal products, electrical machinery, equipment and supplies, information and communication electronics diverse carcinogens Japan [36] Professional and managerial, clerical, sales and service, agriculture, forestry, and fishery, transportation (including machine operation workers), construction and mining, manufacturing, (e.g., homemakers, students, unemployed, miscellaneous) diverse carcinogens Japan [37] Factory manufacturing organic dye/pigment intermediates aromatic amines: ortho-toluidine, aniline, para-toluidine, ortho-anisidine, 2,4-xylidine, ortho-chloroaniline Japan [34] Road transportation workers, motor vehicle engine exhaust, traffic exhaust, housework detergents, cleaners, bleaches, oil fumes during frying, traffic air pollution Korea [102] Maritime workers -seafarers and fishermen diesel exhaust, asbestos, polycyclic aromatic hydrocarbons, ultraviolet radia tion Nordic countries [38] Textile industry cotton dust, caustic soda, acetic acid, hydrogen peroxide, surfactants, formaldehyde, azo dyes, phthalates, perfluorinated compounds Turkey [44] Welding, making cement lubricating/coolant oils, soldering/brazing, degreasing, fumes from quenching/forging or cooling United Kingdom [103] Firefighters polycyclic aromatic hydrocarbons, polychlorinated biphenyls, formaldehyde, benzene, 1,3-butadiene, asbestos, diesel exhaust, circadian disruption from shift work USA [39] Aluminum smelting workers airborne metal dusts, asbestos, polycyclic aromatic hydrocarbons, silica, chemical vapors USA [40] Boat builders cumulative styrene USA [104] Benzidine manufacturing plant benzidine, dichlorobenzidine USA [35] Chemical manufacturing plant aromatic amine: ortho-toluidine USA [42] Automobile manufacturing workers metalworking fluids USA [105] Heavy truck drivers, tractor-trailer drivers, bus drivers, engine mechanics, repairers, equipment operators respirable elemental carbon USA and Spain [31] exposure to carcinogenic effective azo dyes and heavy metal-containing substances [45]. It is not only work in an industry that carries the risk of cancer.…”

Section: Occupational Exposurementioning

confidence: 99%

Androgen receptor modulation and bladder cancer prevention – a short review

Wieczorek¹,

Farooqı²,

Reszka³

2022

Med Pr

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The prevalence of bladder cancer (BCa) is 4 times higher in men as compared to women, and gender differences have been the focus of attention for few years. Androgen receptor (AR) may be a putative explanation for gender differences. It may also be related to unfavourable BCa progression and development because of the increased androgen sensitivity of urothelium to carcinogens. Moreover, cigarette smoking and occupational exposure to carcinogens have been reported to play contributory roles with the highest attributable risk of BCa. In this review, the authors attempt to summarize the seminal research works that synthesized current understanding of the central role of AR in the negative regulation of carcinogen detoxification activity in BCa. In particular, the authors discuss the regulatory effects of 3,3'-diindolylmethane on AR gene transcription through microRNA as its suggested effect on the prevention of BCa. Moreover, to show the still existing problem of occupational exposure and BCa incidence, the authors review recent studies in this area. Based on the rapidly accumulating scientific evidence, it seems pragmatic that androgen/AR-mediated interference in the detoxification mechanism may be inhibited by phytochemicals. Therefore, collectively, nutrition has a key role as gene-nutrient interactions are important contributors to BCa prevention, also through epigenetic modifications. Here, the authors have derived suggestions for future research. Med Pr. 2022;73(2)

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Metalworking fluids and cancer mortality in a US autoworker cohort (1941–2015)

Cited by 13 publications

References 27 publications

Racial disparities in alcohol-related liver disease mortality in a 75 year follow-up study of Michigan autoworkers

Racial disparities in alcohol-related liver disease mortality in a 75 year follow-up study of Michigan autoworkers

Cutting Fluids Usage and Impacts in Metal Workshops in Ibadan, Southwestern Nigeria

Androgen receptor modulation and bladder cancer prevention – a short review

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