Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics

Lerut, Evelyne; Roskams, Tania; Joniau, Steven; Oyen, Raymond; Achten, Ruth; Poppel, Hendrik Van; Dębiec‐Rychter, Maria

doi:10.1016/j.humpath.2006.03.018

Cited by 27 publications

(21 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gains of chromosomes 7 and 17 occur commonly in papillary renal cell carcinoma [32,33], but studies on metanephric adenoma have failed to identify these changes [7,24,26,36], including 2 pediatric cases, and instead, such tumors were found to have a normal karyotype by conventional cytogenetics [11,34,36,37]. There are single reports of monosomy for 2p [38] and trisomy 11 [15], the latter being the sole genetic report on a pediatric metanephric adenofibroma, as well as single reports of balanced translocations in metanephric adenoma, including 1 pediatric case [39,40].…”

Section: Discussionmentioning

confidence: 99%

BRAF mutations in pediatric metanephric tumors

et al. 2015

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

BRAF mutations in pediatric metanephric tumors

et al. 2015

View full text Add to dashboard Cite

“…DNA content analysis of metanephric adenoma by flow cytometry yields diploid histograms [93]. Although most cytogenetic analyses have revealed normal karyotypes, exceptions have included a balanced pericentric inversion involving the short and long arms of chromosome 9 [46,XX, inv (9) (p12q13)], a commonly described normal constitutional variant not known to be associated with increased risk of neoplasia or other diseases, as well as a case displaying the presence of the dual t(1,22)(q22;q13) and t(15,16)(q21;p13) translocations [94]. Several abnormalities in chromosome 2 have been reported.…”

Section: Major Differential Diagnosismentioning

confidence: 99%

Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms

et al. 2009

View full text Add to dashboard Cite

“…Previous karyotyping of a total of five cases revealed negative findings, with the exception of a dual balanced translocation of t(1;22)(q22;13) and t(15;16)(q21;p13) in one case. 5,[8][9][10][11][12] One fluorescence in situ hybridization (FISH) study indicated gain of chromosomes 7 and 17 and loss of Y chromosome-the cytogenetic markers of papillary renal cell carcinoma-in 8 of 11 metanephric adenomas. 13 However, subsequent FISH analyses revealed normal copy numbers for chromosomes 7 and 17.…”

mentioning

confidence: 99%

Detection of chromosome copy number alterations in metanephric adenomas by array comparative genomic hybridization

Pan

Epstein

2010

Modern Pathology

View full text Add to dashboard Cite

Metanephric adenoma is a rare benign renal tumor typically found in adults. Previous cytogenetic analyses, including karyotyping, fluorescence in situ hybridization (FISH), and comparative genomic hybridization, have yielded conflicting results regarding the somatic genetic aberrations of these tumors. In this study, we investigated the genomic profile of nine cases of metanephric adenoma using array comparative genomic hybridization. Two cases revealed multiple chromosomal gains and losses. Three cases showed sporadic chromosomal imbalances involving no more than three chromosomes. Four cases showed normal chromosome copy numbers. The gain of chromosome 19 was the most common finding (five cases), and FISH using 19p and 19q telomeric probes further confirmed this finding. We did not observe consistent gains of chromosomes 7 and 17, which are common in papillary renal cell carcinoma, neither did we find chromosomal alterations frequently present in Wilms' tumors, including chromosome gains of 1q, 7q, and 12, and losses of 11p and 16q. Our series demonstrates that the genetic profile of metanephric adenoma is fundamentally distinct from those of papillary renal cell carcinoma and Wilms' tumor. Modern Pathology (2010) 23, 1634-1640; doi:10.1038/modpathol.2010.162; published online 27 August 2010Keywords: array comparative genomic hybridization; fluorescence in situ hybridization; metanephric adenoma On the basis of the WHO classification of renal tumors, metanephric tumors comprise metanephric adenomas, metanephric adenofibromas, and metanephric stromal tumors, 1 with each of these having its own characteristic clinicopathological presentation. Metanephric adenoma is defined as a highly cellular epithelial tumor composed of small, uniform, and embryonic-appearing cells. The tumor occurs most commonly in patients in their 50s and 60s, with a female preponderance. Although the vast majority of metanephric adenomas behave in a benign fashion, cases of regional lymph node metastasis and sarcomatoid changes have been individually reported. [2][3][4] The morphological and immunohistochemical characteristics of metanephric adenomas have been well described. 5-7 However, cytogenetic or molecular genetic data about this rare tumor are limited and have mostly been reported for single cases. Previous karyotyping of a total of five cases revealed negative findings, with the exception of a dual balanced translocation of t(1;22)(q22;13) and t(15;16)(q21;p13) in one case. 5,[8][9][10][11][12] One fluorescence in situ hybridization (FISH) study indicated gain of chromosomes 7 and 17 and loss of Y chromosome-the cytogenetic markers of papillary renal cell carcinoma-in 8 of 11 metanephric adenomas. 13 However, subsequent FISH analyses revealed normal copy numbers for chromosomes 7 and 17. 4,8,11,14,15 A deletion in chromosome 2p was the only genetic abnormality described in one tumor, and a tumor suppressor gene region on 2p13 was delineated. 16,17 Most recently, a study employing array comparative genomic hybridization (aCGH) repo...

show abstract

Metanephric adenoma during pregnancy: clinical presentation, histology, and cytogenetics

Cited by 27 publications

References 12 publications

BRAF mutations in pediatric metanephric tumors

BRAF mutations in pediatric metanephric tumors

Molecular and cytogenetic insights into the pathogenesis, classification, differential diagnosis, and prognosis of renal epithelial neoplasms

Detection of chromosome copy number alterations in metanephric adenomas by array comparative genomic hybridization

Contact Info

Product

Resources

About