Metanephric Adenoma in a 6-year-old Child With Hemihypertrophy

Küpeli, Serhan; Baydar, Dilek Ertoy; Canakl, Fatih; Yalçn, Bilgehan; Kösemehmetoğlu, Kemal; Tekgül, Serdar; Büyükpamukçu, Münevver

doi:10.1097/mph.0b013e31819e8f72

Cited by 14 publications

(11 citation statements)

References 8 publications

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“…Few cases have been reported since its description by Argani and Beckwith [1][2][3][4], and limited adult cases have also been reported [5,6]. Metanephric stromal tumor along with metanephric adenofibroma and metanephric adenoma represents a spectrum of well-differentiated nephroblastic lesions that appear to be related to Wilms tumor (WT) [7,8]. Recently, a complex homogeneous gain between bands 17q22 and 17q25.3, resulting in partial triplication of the segment between bands 17q22 and 17q24.3, and duplication of the segment between bands 17q24.3 and 17q25.3 is reported cytogenetically [9].…”

mentioning

confidence: 97%

Metanephric stromal tumor: a challenging diagnostic entity in children

Kaçar

Azılı

Cihan

et al. 2011

Journal of Pediatric Surgery

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mentioning

confidence: 97%

Metanephric stromal tumor: a challenging diagnostic entity in children

Kaçar

Azılı

Cihan

et al. 2011

Journal of Pediatric Surgery

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“…155,156 This tumor, MA, and metanephric adenofibroma represent a spectrum of welldifferentiated nephroblastic lesions that appear to be related to WT. 142,155,157 The most characteristic histologic features include an onion skin ring formation around entrapped tubules and blood vessels with vascular changes, including angiodysplasia/epithelioid transformation of medial smooth muscle and myxoid changes. 102 It is composed primarily of spindle cells with a low proliferation index, and diffusely infiltrates the perirenal fat.…”

Section: Metanephric Stromal Tumormentioning

confidence: 99%

“…[140][141][142] Patients can be asymptomatic 143,144 or can have signs and symptoms related to polycythemia, hypertension, hematuria, dysuria, flank or abdominal pain, or a palpable abdominal mass. 3 The lesion has radiologic similarities to RCC and WT, making preoperative diagnosis difficult.…”

Section: Metanephric Adenomamentioning

confidence: 99%

An Approach to Renal Masses in Pediatrics

Malkan¹,

Loh²,

Bahrami³

et al. 2015

Pediatrics

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Renal masses in children may be discovered during routine clinical examination or incidentally during the course of diagnostic or therapeutic procedures for other causes. Renal cancers are rare in the pediatric population and include a spectrum of pathologies that may challenge the clinician in choosing the optimal treatment. Correct identification of the lesion may be difficult, and the appropriate surgical procedure is paramount for lesions suspected to be malignant. The purpose of this article is to provide a comprehensive overview regarding the spectrum of renal tumors in the pediatric population, both benign and malignant, and their surgical management.

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“…In recent years, emerging MA cases have been reported. MA generally occurs in adults, with a peak age of occurrence in the fifth or sixth decade of life, but it is also diagnosed in children [8, 9]. In the present study, patients’ average age and the age range at diagnosis was 43.4 years and 17–67 years.…”

Section: Discussionmentioning

confidence: 56%

The findings of CT and MRI in patients with metanephric adenoma

Yan

Cheng

et al. 2016

Diagn Pathol

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BackgroundMetanephric adenoma (MA) is a benign renal tumor that is difficult to distinguish from a malignant tumor via traditional radiography. The diagnosis of MA is often dependent on postsurgical histopathological examination. In the present report, the imaging features of MA on computer tomography (CT) and magnetic resonance imaging (MRI) were retrospectively evaluated.MethodsEight MA patients, 17–67 years of age, were pathologically confirmed and recruited between April 2009 and November 2014. Four of the eight patients were female. All patients underwent CT scanning, and one patient underwent MRI scanning. Three patients underwent CTA of the renal arteries. All patients underwent resection surgery (radical nephrectomy in five and nephron-sparing surgery in three patients).ResultsThe average tumor size was 44.0 ± 23.6 mm. The lesions in 87.5 % cases were located both in the renal cortex and medulla and exhibited exophytic growth. Plain CT showed that MA tumors were solid, and the average CT value was 37.9 ± 6.7 HU. Dynamic contrast-enhanced CT revealed that enhanced degrees of MA tumors in the renal cortex, renal parenchymal, and pelvic phase were all lower than that of normal renal parenchyma. A slight enhancement in the renal cortex phase and an even higher enhancement in the renal parenchymal phase were observed in seven of the cases. Progressive enhancement in the pelvic phase was found in five cases and a slight decreased enhancement in the pelvic phase in two cases. MRI revealed that MA tumor was isointense on T1WI and isointense on T2WI with some slightly hyperintense areas in the center. CTA of the renal arteries revealed the nutrient artery in one patient and no nutrient artery in two. Immunohistochemical experiments demonstrated that most tumor cells were positive for vimentin, CK, and EMA.ConclusionsMA is a rare benign renal neoplasm. Detailed knowledge of the CT and MRI characteristics of MA plays an important role in MA diagnosis and treatment.

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Metanephric Adenoma in a 6-year-old Child With Hemihypertrophy

Cited by 14 publications

References 8 publications

Metanephric stromal tumor: a challenging diagnostic entity in children

Metanephric stromal tumor: a challenging diagnostic entity in children

An Approach to Renal Masses in Pediatrics

The findings of CT and MRI in patients with metanephric adenoma

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