Metanephric adenoma of kidney: a rare and distinct entity

Patil, Purwa; Bhatia, Varsha; Arole, Vidya; Thakare, Nisha

doi:10.18203/2320-6012.ijrms20160549

Cited by 1 publication

(5 citation statements)

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“…3 MA is a rare benign renal neoplasm that may clinically and histopathologically mimic other malignant renal tumors. 4 This tumor occurs at a wide age distribution but generally afflicts middle-aged individuals with a female predominance (2:1). 1 In children, MA overlaps in morphology with epithelial predominant Wilms tumor, while in adults (≥30 years) MA can mimic the papillary renal cell carcinoma morphologically.…”

Section: Discussionmentioning

confidence: 99%

“…7 Clinically, MA is most often asymptomatic and diagnosed incidentally on imaging studies, but may present as an abdominal mass accompanied by flank pain and hematuria. 4 Radiologically, these tumors are well defined, solid mass lesions without enhancement in the posterior aspect of the kidney as viewed in contrast-enhanced CT images. 6 However, it is still difficult to distinguish MA from other entities just by imaging features alone.…”

Section: Discussionmentioning

confidence: 99%

“…The stroma is usually acellular, edematous, and may show myxoid degeneration. 4 It is different from Wilms tumor as it does not contain the blastemal component and lacks atypia and mitotic figures. 8 In the present case, atypical features and mitoses were absent.…”

Section: Discussionmentioning

confidence: 99%

“…AMACR, CK7, and CD10 are usually not expressed, which excludes the diagnosis of pRCC. 4 Regarding molecular and genetic studies, the BRAF V600E gene mutation and 2p16 gene changes are the most common findings in the MA. 2 The positive expression of the VE1 protein is correlated with the mutated BRAF gene.…”

Section: Discussionmentioning

confidence: 99%

“…3 It is reported that MA accounts for approximately 0.2% of the adult renal epithelial neoplasms. 4 It generally occurs in adults and has an excellent prognosis. 5 The origin of these neoplasms is not entirely known; however, they are thought to be associated with Wilms tumor.…”

Section: Introductionmentioning

confidence: 99%

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Metanephric Adenoma with cystic changes- An uncommon presentation of a rare tumor in a young adult

et al. 2020

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Metanephric adenoma (MA) is a rare benign neoplasm of the kidney that is usually asymptomatic and incidentally diagnosed. MA usually present as a solid mass; however, a cystic presentation has been reported. The main differential diagnosis of MA is the epithelial predominant Wilms tumor (e-WT) and the solid variant of papillary renal cell carcinoma (pRCC). The presence of the BRAF gene mutation has recently been reported in 85% of MA, and less than 10% of cases of MA do not express this specific gene mutation. Herein we report a 22-year-old man who presented with back pain and abdominal discomfort with a renal mass on the computed tomographic scan. The diagnosis of metanephric adenoma was confirmed histopathologically. In our case, the tumor presented as a solid and cystic mass hence mimicking a papillary renal cell carcinoma. The VE1 protein, which correlates with BRAF gene mutation, did not show any significant expression. We want to highlight that MA can present as a cystic lesion that should be taken into account to avoid unnecessary radical nephrectomy. Also, we demonstrated that a subset of MA might not harbor the BRAF gene and, they are classified as the BRAF wild type MA.

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Section: Discussionmentioning

confidence: 99%