Metanephric Adenoma of the Kidney: Case Report and Review of the Literature

Schmelz, Hans-Ulrich; Stoschek, M.; Schwerer, Michael J.; Danz, B.; Hauck, Ekkehard W.; Weidner, W.; Sparwasser, C.

doi:10.1007/s11255-004-6105-2

Cited by 25 publications

(38 citation statements)

References 22 publications

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“…Davis et al [2] found 50% of tumours were discovered incidentally. For patients with symptoms, the most common were abdominal or flank pain, haematuria and a palpable mass [4]. Among possible clinical findings, the incidence of polycythaemia with MA is remarkable.…”

Section: Discussionmentioning

confidence: 99%

“…The cut surfaces vary from grey to tan to yellow and may be soft or firm. Calcification is present in approximately 20% and a few are densely calcified [4]. Foci of haemorrhage and necrosis are common [4,7].…”

Section: Discussionmentioning

confidence: 99%

“…Calcification is present in approximately 20% and a few are densely calcified [4]. Foci of haemorrhage and necrosis are common [4,7]. The histological features of MA are distinctive and are characterised by epithelial cells with different amounts of cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…The histological features of MA are distinctive and are characterised by epithelial cells with different amounts of cytoplasm. The adenomatous components are composed of uniform small cells arranged in tubular or papillary architectural patterns [4]. In addition, immunohistochemical staining with CD57, WT1 and CK7 may be useful to differentiate MA from papillary renal cell carcinoma when distinction by histological features alone proves difficult.…”

Section: Discussionmentioning

confidence: 99%

“…Until now it was thought to have a benign course. In the English language literature no more than 100 cases of MAs have been reported, and in only a few have the imaging findings been well illustrated [2][3][4][5][6][7][8][9][10][11][12][13]. We report two cases of MA in a 17-year-old and a 30-year-old female and describe their appearances on CT and ultrasonography.…”

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confidence: 99%

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CT and ultrasound findings of metanephric adenoma: a report of two cases and literature review

Zhang¹,

Yang²,

Shen³

et al. 2011

BJR

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ABSTRACT. Metanephric adenoma (MA) of the kidney is an uncommon benign epithelial tumour that can present at any age. The histology of the lesion is well established, but imaging findings have been described in only a few cases. We report the CT and ultrasound appearance of MA in two females to increase the awareness of this entity among radiologists. Its recognition may facilitate nephron-sparing surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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CT and ultrasound findings of metanephric adenoma: a report of two cases and literature review

Zhang¹,

Yang²,

Shen³

et al. 2011

BJR

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Fine‐needle aspiration of metanephric adenoma of the kidney with clinical, radiographic and histopathologic correlation: A review

Blanco

Schein

Patel

et al. 2013

Diagnostic Cytopathology

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Metanephric adenoma of the kidney is an uncommon benign epithelial neoplasm with only a small number of reports that describe its cytologic features. We describe two additional cases of metanephric adenoma diagnosed on fine-needle aspiration biopsy and review the available literature. Our cases showed similar cytology and were composed of cellular smears with numerous clusters of small, oval to round cells arranged in a microfollicular pattern and papillary configurations. The tumor cells had scant cytoplasm, fine chromatin and absent nucleoli. Psamomma bodies, nuclear atypia, cellular cpleomorphism, necrosis, and mitoses were absent. Because of the rarity of this tumor and the common cytologic features it shares with other lesions, including malignant tumors such as Wilms' tumor and papillary renal cell carcinoma, awareness of the cytologic features of metanephric adenoma may aid in avoiding a diagnosis of malignancy, especially preoperatively, and in guiding the proper management for the patients.

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Malignant Renal Tumors

Shehata

Naguib

Lin

et al. 2014

Pediatric Malignancies: Pathology and Imaging

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Renal tumors account for approximately 6-7 % of all pediatric cancers, with Wilms' tumor being the most common malignancy [ 1 , 2 ]. Current classifi cation and staging criteria for renal tumors, aided by advances in molecular and cytogenetic abnormalities, have allowed accurate diagnostic, staging, and therapeutic protocols [ 2 ], elucidated new categories of renal neoplasms, and created more inclusive classifi cation (Table 10.1 ) [ 2 , 3 ]. Overview of Imaging FeaturesThe imaging evaluation of a suspected pediatric renal mass should always begin with ultrasound. Sonography is readily available, can be performed without sedation and intravenous contrast, and does not expose the child to ionizing radiation. If a renal mass is identifi ed on ultrasound, further evaluation of the renal vessels and inferior vena cava (IVC) with both gray scale and color Doppler images are required to detect vascular extension, present in up to 10 % of cases [ 4 ]. Further evaluation with contrast enhanced computed tomography (CT) or magnetic resonance imaging (MRI) is also required for local staging of the mass prior to any intervention, as per the guidelines of the Children's Oncology Group (COG). Either modality can be used, depending on institutional availability and expertise [ 5 ].In keeping with the As Low As Reasonably Achievable (ALARA) principle regarding ionizing radiation exposure, pre-contrast and multiphase contrast enhanced CT images are not required for diagnosis or staging of pediatric renal tumors [ 6 ]. A single-phase study in the portal venous phase (approximately 50 s after contrast injection) suffi ciently stages a renal tumor and delineates relevant anatomy. Multiplanar CT reconstructions or multiplanar scanning with MRI can confi rm the renal origin of the mass and assess its relationship to vital structures such as the renal vessels. If a partial nephrectomy is being considered, multiphase images are helpful to determine the relationship of the mass to the renal vessels and collecting system. A CT of the chest is required in all malignant renal tumors to evaluate for potential lung metastasis. Wilm's Tumor Defi nitionWilms' tumor ( syn: nephroblastoma), a malignant neoplasm originating from nephrogenic blastemal cells, is the second most common malignant, solid extracranial tumor in children [ 1 , 7 , 8 ]. It is a traditional blastematous tumor, exhibiting various stages of embryonic development and multiple lines of differentiation. Clinical Features and EpidemiologyIn children ranging from 0 to 15 years of age, Wilms' tumor occurs in seven to ten cases per million annually (1 in 10,000 children) and accounts for approximately 95 % of renal tumors, and comprises 6-7 % of all pediatric tumors [ 7 , 9 , 10 ]. It is the fi fth most common pediatric tumor and the second most common intraabdominal tumor in children [ 11 ].

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Metanephric Adenoma of the Kidney: Case Report and Review of the Literature

Cited by 25 publications

References 22 publications

CT and ultrasound findings of metanephric adenoma: a report of two cases and literature review

CT and ultrasound findings of metanephric adenoma: a report of two cases and literature review

Fine‐needle aspiration of metanephric adenoma of the kidney with clinical, radiographic and histopathologic correlation: A review

Malignant Renal Tumors

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