Metanephric stromal tumour: A rare pediatric benign stromal specific renal neoplasm

Khutti, Seema; Kumar, Ramani; Karl, Sampath

doi:10.4103/0970-1591.109985

Cited by 4 publications

(9 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Proliferative lesions of the tubules or interstitium were rare but included cystic tubular epithelial hyperplasia (Figure 5A) and a congenital fibrogenic proliferative lesion (Figure 5B and inset) resembling a medullary fibrous hamartoma 9 or metanephric stromal tumour 10,11 in humans. The later was characterized by medullary proliferation of bland spindle-shaped stromal cells surrounding what appears to be trapped renal tubules (Figure 5B and inset).…”

Section: Resultsmentioning

confidence: 99%

Normal Anatomy, Histology, and Spontaneous Pathology of the Kidney, and Selected Renal Biomarker Reference Ranges in the Cynomolgus Monkey

et al. 2019

View full text Add to dashboard Cite

To further our understanding of the nonhuman primate kidney anatomy, histology, and incidences of spontaneous pathology, we retrospectively examined kidneys from a total of 505 control Cynomolgus monkeys ( Macaca fascicularis; 264 male and 241 females) aged 2 to 6 years, from toxicity studies. Kidney weights, urinalysis, and kidney-related clinical biochemistry parameters were also evaluated. Although the functional anatomy of the monkey kidney is relatively similar to that of other laboratory animals and humans, a few differences and species-specific peculiarities exist. Unlike humans, the macaque kidney is unipapillate, with a relatively underdeveloped papilla, scarce long loops of Henle, and a near-equivalent cortical to medullary ratio. The most common spontaneous microscopic findings were interstitial infiltrates or interstitial nephritis and other tubular lesions, but several forms of glomerulopathy that may be interpreted as drug-induced were occasionally observed. Common incidental findings of little pathological significance included: papillary mineralization, epithelial pigment, multinucleate cells, cuboidal metaplasia of the Bowman’s capsule, and urothelial inclusions. Kidney weights, and some clinical chemistry parameters, showed age- and sex-related variations. Taken together, these data will aid the toxicologic pathologist to better evaluate the nonhuman primate kidney and assess the species’ suitability as a model for identifying and characterizing drug-induced injury.

show abstract

Section: Resultsmentioning

confidence: 99%

Normal Anatomy, Histology, and Spontaneous Pathology of the Kidney, and Selected Renal Biomarker Reference Ranges in the Cynomolgus Monkey

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Beckwith has suggested that MST may represent the result of maturation of intralobar nephrogenic rests with the loss of active blastemal component. [ 1 7 ]…”

Section: Discussionmentioning

confidence: 99%

“…MST is usually centered in the renal medulla;[ 7 9 ]however, in rare cases, it seemed to originate from renal cortex. [ 3 ]…”

Section: Discussionmentioning

confidence: 99%

“…MST is differentiated from CMN by its scalloped, subtly infiltrative borders, in contrast with the deeply invasive character of CMN. [ 1 7 ]In addition, MST stains for CD34 while tumor cells in CMN are positive for desmin. [ 1 7 ]Cytogenetically, additional copies of whole chromosome 17, deletion on long arm of chromosome 3 (3q21q24), and duplication of the short arm of chromosome 11 (11p15) have commonly been reported in CMN.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 7 ]In addition, MST stains for CD34 while tumor cells in CMN are positive for desmin. [ 1 7 ]Cytogenetically, additional copies of whole chromosome 17, deletion on long arm of chromosome 3 (3q21q24), and duplication of the short arm of chromosome 11 (11p15) have commonly been reported in CMN. [ 11 ]In MST, a complex homogeneous gain of the segment between bands 17q22 and 17q25.3, resulting in partial triplication and duplication of the long arm of chromosome 17, was noticed.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Metanephric stromal tumor: An unusual presentation of a rare paediatric renal neoplasm

Abdeljelil

Hadhri

Njima

et al. 2018

Afr J Paediatr Surg

View full text Add to dashboard Cite

A 2-year-old boy with prenatal diagnosis of a malformation uropathy was referred to paediatric surgery department. On systemic examination, there were no palpable masses. An ultrasonography of abdomen with color Doppler, a renal artery angiographic and scintigraphy revealed a preostial aneurysm at the left renal artery. The patient had a left nephrectomy. Grossly, the specimen measured 75 mm × mm 50 × 20 mm with renal artery aneurysm measuring 30 mm × 35 mm. On cut section, the renal parenchyma contained a whitish tumor that measured 35 mm × 10 mm. Histopathologically, this tumor was diagnosed as metanephric stromal tumor.

show abstract

Reevaluation of metanephric stromal tumor two decades after it was named: A narrative review

Zhang

Yadav

Niu

et al. 2020

Journal of Pediatric Urology

View full text Add to dashboard Cite

Metanephric stromal tumour: A rare pediatric benign stromal specific renal neoplasm

Cited by 4 publications

References 5 publications

Normal Anatomy, Histology, and Spontaneous Pathology of the Kidney, and Selected Renal Biomarker Reference Ranges in the Cynomolgus Monkey

Normal Anatomy, Histology, and Spontaneous Pathology of the Kidney, and Selected Renal Biomarker Reference Ranges in the Cynomolgus Monkey

Metanephric stromal tumor: An unusual presentation of a rare paediatric renal neoplasm

Reevaluation of metanephric stromal tumor two decades after it was named: A narrative review

Contact Info

Product

Resources

About